Transfusion Medicine - Jeffrey McCullough

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Departments of Pathology Molecular and Cell Based Medicine Icahn School of Medicine at Mount Sinai New York, NY, USA

      Randal Covin, MD Pacific Northwest Region American Red Cross Portland, OR, USA

      Thomas Gniadek, MD, PhD Northshore University HealthSystem Evanston, IL, USA

      Sarah J. Ilstrup, MD Transfusion Medicine Work Group and Front End Work Group for Intermountain Healthcare Pathology and Laboratory Medicine Salt Lake City, UT, USA

      Alesia Kaplan, MD Department of Pathology Division of Transfusion Medicine University of Pittsburgh Pittsburgh, PA, USA

      Stephanie Kinney, MD Cincinnati Children’s Hospital Medical Center Cincinnati, OH, USA

      Ulrike F. Koenigbauer, Dr. med. Bavarian Red Cross Blood Service Nuremberg, Germany

      Vincent Laroche, MD CHU de Québec – Université Laval Department of Medicine, Hematology Division Montreal, Quebec, Canada

      Kristin M. Mascotti, MD, MS‐HQSM NCH Health System Naples, FL, USA

      Jeffrey McCullough University of Minnesota Minneapolis, MN, USA

      David H. McKenna, MD Department of Laboratory Medicine and Pathology Molecular & Cellular Therapeutics University of Minnesota Minneapolis/Saint Paul, MN, USA

      Ramkrishna L. Reddy, MD American Red Cross Blood Services, West Division Omaha, NE, USA

      David F.Stroncek, MD Center for Cellular Engineering Department of Transfusion Medicine National Institutes of Health Clinical Center Bethesda, MD, USA

      James Stubbs, MD Transfusion Medicine Mayo Clinic Rochester, MN, USA

      Nancy Van Buren, MD Innovative Blood Resources Division of New York Blood Center St. Paul, MN, USA

      Thomas Watkins, DO, PhD MEDIC Regional Blood Center Knoxville, TN, USA

      In the first four editions, I wrote the entire book except for the HLA chapter, which was done by my good friend and former fellow, Yoon Choo. For this fifth edition, it seemed appropriate to begin to involve others but I wanted to keep this as a Minnesota book. Thus, I invited some former fellows to assist with this edition. These authors represent quite a range of stages of the fellowship program. David Stroncek dates back to the 1980s and the early days of unrelated marrow transplants to more recent fellows Tom Gniadeck and Stephanie Kinney who has provided a new chapter on pediatric transfusion medicine. Two authors are from countries other than the United States: Vincent Laroche from Canada and Ulrike Konigbauer from Germany, whose husband Josef was a wonderful musical and scientific mentor to one of my sons. One of the authors (Ram Reddy) retired after preparing his chapter and sadly another author (Randy Coven) died unexpectedly during the preparation of this book. Another former fellow and good friend, Phyllis Warkentin has not authored any chapter in the book but is acknowledged in the chapter on cellular engineering for her work in establishing our first bone marrow‐processing laboratory, which ultimately led to the current sophisticated comprehensive facility at University of Minnesota, which provided the initial venue for doctors McKenna and Stroncek, who have co‐authored the above‐mentioned chapter in this book.

      Tom Watkins deals with the blood donor situation which continues to be a challenge; Gary Bachowski the complex evaluation of donors and blood collection, and Alecia Kaplan component production and the wide variety of resulting components and Nancy Van Buren the complex laboratory testing of donated blood. Sarah Ilstrup brings us up to date with blood groups and ulrke Konigbauer the extensive process of getting the right blood components to right patients at the right time and safely. Vincent Laroche educates us about clinical uses of blood components and Jim Stubbs elaborates on some special clinical situations. Scott Koepsell summarizes current perspectives on transfusion complications. Dave Mckenna and Dave Stroncek provide a wonderful chapter on exciting novel blood related cellular products.

      Preparing the preface for this fifth edition provides a nice opportunity to reflect on the evolution of the content of these five editions. There are still challenges in recruiting adequate number of donors to maintain a regular supply of blood, given the demographic evolution underway and its impact on potential donor availability. This has led to discussions on paying donors, which would have been unthinkable at the time of the first edition. Blood centers evolved from multifaceted community hubs into manufacturing sites almost entirely focused on blood collection, having shed most of the exciting diverse activities they carried out during a couple of decades.

      The organizations that provide the supply have gone through mergers and are now operated almost like a commodity business with substantial competition. While this might have been inevitable, I find it unfortunate.

      Collection of blood products by apheresis has continued to thrive and essentially all platelets in the United States are now produced by apheresis. Unimagined in the first edition is collection of a modest portion of red cells by apheresis. Therapeutic apheresis has evolved for the most part away from blood banks and transfusion medicine but is widely used to treat a variety of conditions.

      A major development in transfusion medicine during these five additions relates to blood safety and transfusion‐transmitted infections. Blood safety has continued to improve with current rates of test positive units of less than one in a million. Infectious agents have come and some have gone. Our good fortune is that respiratory viruses such as influenza and, more recently, SARS Co‐V are not transmitted by blood transfusion. We have arrived at the point where bacterial contamination of platelets is now the major transmissible infection risk.

      Pathogen reduction, a paradigm shift in approach to blood safety, has progressed much more slowly than I imagined. It is disappointing that more than 20 years after some of these initial efforts, there is only one technology approved in the United States and that is for platelets and plasma but we still have no approved PR technology for whole load or red cells. While these PR technologies are not particularly scientifically complex, applying them to the world’s blood supply has been difficult and expensive, resulting in disappointingly slow progress. This is probably due to multiple factors: the cost of developing and implementing the technology, unrealistic and unreasonable expectations of how the technology will perform, failure of leadership of transfusion medicine and blood banking to enthusiastically support and assist in the development of this technology, and failure of regulatory agencies to be open‐minded and recognize that these are first‐generation technologies. Clearly, this is the future of blood safety; we just need to get the right technologies and get them implemented.

      The use of plasma derivatives, particularly IVIG, has grown enormously, leading to the establishment of many centers for collecting plasma from paid donors in the United States. In fact, these US paid plasma donors form the basis for a large portion of the world’s plasma derivative products.

      The molecular basis of blood groups has now been determined and some molecular testing is making its way into practice. Little of this was known at the time of the first edition.

      Granulocytes for transfusion continue to be a fringe product and it is surprising that after almost 50 years, their clinical value has never been established. The trial (RING) that probably would have settled this was unfortunately halted prematurely due to ending of NIH funding for this work.

      Quality systems was an appendix to the first edition because i had written the book before deciding to include the topic. This expertise has been introduced into blood banking and is now an integral part of our

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