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      Transfusion Medicine

       FIFTH EDITION

       Edited by

       Jeffrey McCullough

      University of Minnesota

      Minneapolis, MN, USA

      This edition first published 2021

      © 2021 John Wiley & Sons Ltd

      Edition History Third edition published 2011; fourth edition published 2016 by John Wiley & Sons.

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

      The right of Jeffrey McCullough to be identified as the author of the editorial material in this work has been asserted in accordance with law.

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      Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

       Library of Congress Cataloging‐in‐Publication Data

      Names: McCullough, Jeffrey, 1938– editor. | McCullough, Jeffrey, 1938– Transfusion medicine.

      Title: Transfusion medicine / edited by Jeffrey McCullough.

      Other titles: Transfusion medicine (McCullough)

      Description: Fifth edition. | Hoboken, NJ : Wiley‐Blackwell, 2021. | Preceded by Transfusion medicine / Jeffrey McCullough. 4th edition. 2017. | Includes bibliographical references and index.

      Identifiers: LCCN 2020053116 (print) | LCCN 2020053117 (ebook) | ISBN 9781119599531 (paperback) | ISBN 9781119599555 (adobe pdf) | ISBN 9781119599562 (epub)

      Subjects: MESH: Blood Transfusion | Blood Banks–organization & administration | Blood Donors | Blood Group Antigens

      Classification: LCC RM171 (print) | LCC RM171 (ebook) | NLM WB 356 | DDC 615.3/9–dc23

      LC record available at https://lccn.loc.gov/2020053116 LC ebook record available at https://lccn.loc.gov/2020053117

      Cover image: [Production Editor to insert]

      Cover design by [Production Editor to insert]

      Gary Bachowski, MD, PhD American Red Cross Blood Services St. Paul, MN, USA

      Isabelle Blais‐Normandin, MD CHU de Québec – Université Laval Department of Medicine, Hematology Division Montreal, Quebec, Canada

      S.

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