LITMIR.BIZ

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are now being investigated. Meanwhile new drugs are being synthesized -- drugs that reinforce or correct or interfere with the actions of the various chemicals, by means of which the nervous system performs its daily and hourly miracles as the controller of the body, the instrument and medi­ator of consciousness. From our present point of view, the most interesting fact about these new drugs is that they temporarily alter the chemistry of the brain and the associated state of the mind without doing any permanent damage to the organism as a whole. In this respect they are like soma -- and profoundly unlike the mind-changing drugs of the past. For example, the classical tranquillizer is opium. But opium is a dangerous drug which, from neolithic times down to the present day, has been making addicts and ruining health. The same is true of the classical euphoric, alco­hol -- the drug which, in the words of the Psalmist, "maketh glad the heart of man." But unfortunately alcohol not only maketh glad the heart of man; it also, in excessive doses, causes illness and addiction, and has been a main source, for the last eight or ten thou­sand years, of crime, domestic unhappiness, moral deg­radation and avoidable accidents.

      Among the classical stimulants, tea, coffee and maté are, thank goodness, almost completely harmless. They are also very weak stimulants. Unlike these "cups that cheer but not inebriate," cocaine is a very powerful and a very dangerous drug. Those who make use of it must pay for their ecstasies, their sense of unlimited physical and mental power, by spells of agonizing depression, by such horrible physical symptoms as the sensation of being infested by myriads of crawling insects and by paranoid delusions that may lead to crimes of violence. Another stimulant of more recent vintage is amphetamine, better known under its trade name of Benzedrine. Amphetamine works very effec­tively -- but works, if abused, at the expense of mental and physical health. It has been reported that, in Ja­pan, there are now about one million amphetamine ad­dicts.

      Of the classical vision-producers the best known are the peyote of Mexico and the southwestern United States and Cannabis sativa, consumed all over the world under such names as hashish, bhang, kif and marihuana. According to the best medical and anthro­pological evidence, peyote is far less harmful than the White Man's gin or whisky. It permits the Indians who use it in their religious rites to enter paradise, and to feel at one with the beloved community, without making them pay for the privilege by anything worse than the ordeal of having to chew on something with a revolting flavor and of feeling somewhat nauseated for an hour or two. Cannabis sativa is a less innocuous drug -- though not nearly so harmful as the sen­sation-mongers would have us believe. The Medical Committee, appointed in 1944 by the Mayor of New York to investigate the problem of marihuana, came to the conclusion, after careful investigation, that Can­nabis sativa is not a serious menace to society, or even to those who indulge in it. It is merely a nuisance.

      From these classical mind-changes we pass to the latest products of psychopharmacological research. Most highly publicized of these are the three new tranquillizers, reserpine, chlorpromazine and meprobamate. Administered to certain classes of psychotics, the first two have proved to be remarkably effective, not in curing mental illnesses, but at least in temporarily abolishing their more distressing symptoms. Meproba­mate (alias Miltown) produces similar effects in per­sons suffering from various forms of neurosis. None of these drugs is perfectly harmless; but their cost, in terms of physical health and mental efficiency, is ex­traordinarily low. In a world where nobody gets any­thing for nothing tranquillizers offer a great deal for very little. Miltown and chlorpromazine are not yet soma; but they come fairly near to being one of the aspects of that mythical drug. They provide temporary relief from nervous tension without, in the great ma­jority of cases, inflicting permanent organic harm, and without causing more than a rather slight im­pairment, while the drug is working, of intellectual and physical efficiency. Except as narcotics, they are probably to be preferred to the barbiturates, which blunt the mind's cutting edge and, in large doses, cause a number of undesirable psychophysical symp­toms and may result in a full-blown addiction.

      In LSD-25 (lysergic acid diethylamide) the phar­macologists have recently created another aspect of soma -- a perception-improver and vision-producer that is, physiologically speaking, almost costless. This ex­traordinary drug, which is effective in doses as small as fifty or even twenty-five millionths of a gram, has power (like peyote) to transport people into the other world. In the majority of cases, the other world to which LSD-25 gives access is heavenly; alternatively it may be purgatorial or even infernal. But, positive, or negative, the lysergic acid experience is felt by al­most everyone who undergoes it to be profoundly significant and enlightening. In any event, the fact that minds can be changed so radically at so little cost to the body is altogether astonishing.

      Soma was not only a vision-producer and a tranquil­lizer; it was also (and no doubt impossibly) a stimu­lant of mind and body, a creator of active euphoria as well as of the negative happiness that follows the re­lease from anxiety and tension.

      The ideal stimulant -- powerful but innocuous -- still awaits discovery. Amphetamine, as we have seen, was far from satisfactory; it exacted too high a price for what it gave. A more promising candidate for the role of soma in its third aspect is Iproniazid, which is now being used to lift depressed patients out of their misery, to enliven the apathetic and in general to in­crease the amount of available psychic energy. Still more promising, according to a distinguished phar­macologist of my acquaintance, is a new compound, still in the testing stage, to be known as Deaner. Deaner is an amino-alcohol and is thought to increase the production of acetyl-choline within the body, and thereby to increase the activity and effectiveness of the nervous system. The man who takes the new pill needs less sleep, feels more alert and cheerful, thinks faster and better -- and all at next to no organic cost, at any rate in the short run. It sounds almost too good to be true.

      We see then that, though soma does not yet exist (and will probably never exist), fairly good substi­tutes for the various aspects of soma have already been discovered. There are now physiologically cheap tranquillizers, physiologically cheap vision-producers and physiologically cheap stimulants.

      That a dictator could, if he so desired, make use of these drugs for political purposes is obvious. He could ensure himself against political unrest by changing the chemistry of his subjects' brains and so making them content with their servile condition. He could use tranquillizers to calm the excited, stimulants to arouse enthusiasm in the indifferent, halluciants to distract the attention of the wretched from their miseries. But how, it may be asked, will the dictator get his subjects to take the pills that will make them think, feel and behave in the ways he finds desirable? In all probabil­ity it will be enough merely to make the pills available. Today alcohol and tobacco are available, and people spend considerably more on these very unsatisfactory euphorics, pseudo-stimulants and sedatives than they are ready to spend on the education of their children. Or consider the barbiturates and the tranquillizers. In the United States these drugs can be obtained only on a doctor's prescription. But the demand of the Ameri­can public for something that will make life in an urban-industrial environment a little more tolerable is so great that doctors are now writing prescriptions for the various tranquillizers at the rate of forty-eight millions a year. Moreover, a majority of these prescrip­tions are refilled. A hundred doses of happiness are not enough: send to the drugstore for another bottle -- and, when that is finished, for another. . . . There can be no doubt that, if tranquillizers could be bought as easily and cheaply as aspirin, they would be con­sumed, not by the billions, as they are at present, but by the scores and hundreds of billions. And a good, cheap stimulant would be almost as popular.

      Under a dictatorship pharmacists would be in­structed to change their tune with every change of circumstances. In times of national crisis it would be their business to push the sale of stimulants. Between crises, too much alertness and energy on the part of his subjects might prove embarrassing to the tyrant. At such times the masses would be urged to buy tran­quillizers and vision-producers. Under the influence of these soothing syrups they could be relied upon to give their master no trouble.

      As things now stand, the tranquillizers may prevent some people from giving enough trouble, not only to their rulers, but even to themselves. Too much tension is a disease; but so is too little. There are certain occasions when we ought to be tense, when an excess of tranquillity (and especially of tranquillity imposed from the outside, by a chemical) is entirely inappropri­ate.

      At

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