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заметных нарушений гомеостаза глюкозы[339][340]. Высказано предположение, что эта «преддиабетическая фаза» является результатом прогрессирующей недостаточности р-клеток и относительной инсулинопении и повышает значимость анаболического действия инсулина при MB и неблагоприятного влияния недостаточности инсулина на метаболизм глюкозы, состояние питания и клинические исходы у этих пациентов[341].

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      23

      Mahadeva

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<p>339</p>

Lanng S, Thorsteinsson B, Nerup J, Koch С Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis. Eur J Pediatr1992; 151:684-7.

<p>340</p>

Dobson L, Sheldon CD, Hattersley AT. Understanding cysticfibrosis-re-lated diabetes: best thought of as insulin deficiency? J R Soc Med 2004;97 Suppl 44: 26–35.

<p>341</p>

Dobson L, Sheldon CD, Hattersley AT. Understanding cysticfibrosis-re-lated diabetes: best thought of as insulin deficiency? J R Soc Med 2004;97 Suppl 44: 26–35.