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Over the last decade, advances in science and technology have profoundly changed the face of light microscopy. Research scientists need to learn new skills in order to use a modern research microscope–skills such as how to align microscope optics and perform image processing. Fundamentals of Light Microscopy and Electronic Imaging explores the basics of microscope design and use. The comprehensive material discusses the optical principles involved in diffraction and image formation in the light microscope, the basic modes of light microscopy, the components of modern electronic imaging systems, and the image processing operations necessary to acquire and prepare an image. Written in a practical, accessible style, Fundamentals of Light Microscopy and Electronic Imaging reviews such topics as: Illuminators, filters, and isolation of specific wavelengths Phase contrast and differential interference contrast Properties of polarized light and polarization microscopy Fluorescence and confocal laser scanning microscopy Digital CCD microscopy and image processing Each chapter includes practical demonstrations and exercises along with a discussion of the relevant material. In addition, a thorough glossary assists with complex terminology and an appendix contains lists of materials, procedures for specimen preparation, and answers to questions. An essential resource for both, experienced and novice microscopists.

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Many books have been written about the finite element method; little however has been written about procedures that assist a practicing engineer in undertaking an analysis in such a way that errors and uncertainties can be controlled. In A Practical Guide to Reliable Finite Element Modelling, Morris addresses this important area. His book begins by introducing the reader to finite element analysis (FEA), covering the fundamental principles of the method, whilst also outlining the potential problems involved. He then establishes consistent methods for carrying out analyses and obtaining accurate and reliable results, concluding with a new method for undertaking error control led analyses which is illustrated by means of two case studies. The book addresses a number of topics that: • Systematically cover an introduction to FEA, how computers build linear-static and linear-dynamic finite element models, the identification of error sources, error control methods and error-controlled analyses. • Enable the reader to support the design of complex structures with reliable, repeatable analyses using the finite element method. • Provide a basis for establishing good practice that could underpin a legal defence in the event of a claim for negligence. A Practical Guide to Reliable Finite Element Modelling will appeal to practising engineers engaged in conducting regular finite element analyses, particularly those new to the field. It will also be a resource for postgraduate students and researchers addressing problems associated with errors in the finite element method. This book is supported by an author maintained website at http://www.femec.co.uk

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In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. Authoritative update on key mechanisms of airway constriction in Asthma and COPD Relates latest research to bronchodilator therapy Multi-contributed text, co-coordinated by two of the leading authorities in the field.

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Published by the American Geophysical Union as part of the Special Publications Series. This is a research monograph and not a textbook. Here I demonstrate analytically how the observed, opposing, latitudinal gradients in the average range and richness of local vascular land plant species are (outside the moist-tropical zone, at least) driven primarily by the local temporal and spatial variability of shortwave radiative flux at the canopy top. (The term «richness» as used here means the local number of different vascular land plant species unlimited by the size of the area sampled.) The hypotheses are simplistic but are nevertheless convincingly accurate in extratropical latitudes when tested against observations over the continental land surfaces of the Northern Hemisphere, the only areas tested here.

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Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections – an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.

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Molecular and Genetic Analysis of Human Traits will address the science student human genetics market. Although incorporating two basic themes: how do we establish that a trait is hereditary, and how is the human genome organized, it will also address relevant clinical examples and key related ethical issues. New attractive features have been added, including a chapter project, and end of chapter exercises which rely on real data. Each chapter includes end of chapter exercises, and references. In-text examples and internet references are cited. Most figures will be 2 color, with some 4 color inserts.

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Scattering-based numerical methods are increasingly applied to the numerical simulation of distributed time-dependent physical systems. These methods, which possess excellent stability and stability verification properties, have appeared in various guises as the transmission line matrix (TLM) method, multidimensional wave digital (MDWD) filtering and digital waveguide (DWN) methods. This text provides a unified framework for all of these techniques and addresses the question of how they are related to more standard numerical simulation techniques. Covering circuit/scattering models in electromagnetics, transmission line modelling, elastic dynamics, as well as time-varying and nonlinear systems, this book highlights the general applicability of this technique across a variety of disciplines, as well as the inter-relationships between simulation techniques and digital filter design. provides a comprehensive overview of scattering-based numerical integration methods. reviews the basics of classical electrical network theory, wave digital filters, and digital waveguide networks. discusses applications for time-varying and nonlinear systems. includes an extensive bibliography containing over 250 references. Mixing theory and application with numerical simulation results, this book will be suitable for both experts and readers with a limited background in signal processing and numerical techniques.

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This concise yet comprehensive treatment of the effects of spaceflight on biological systems includes issues at the forefront of life sciences research, such as gravitational biology, immune system response, bone cell formation and the effects of radiation on biosystems. Edited by a leading specialist at the European Space Agency (ESA) with contributions by internationally renowned experts, the chapters are based on the latest space laboratory experiments, including those on SPACELAB, ISS, parabolic flights and unmanned research satellites. An indispensable source for biologists, medical researchers and astronautics experts alike. The results of Space flight experiments, ground controls and flight simulations pave the way for a better understanding of gravity reactions in various organisms down to molecular mechanisms. This publication marks also the beginning of a new Space flight era with the construction and exploitation of the International Space Station (ISS) which provides a platform for an in-depth continuation of experiments under weightlessness in Low Earth Orbit and beyond.

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Contamination control is being used by more and more industries where the highest level of cleanliness and hygiene is of vital importance. This book covers the basic principles of contamination control and cleanroom technology from a holistic point of view. It deals with cleanliness and hygiene and their effects on the outcome of a process, reflecting the latest results from both scientific and practical points of view. The following topics are covered: contaminants and how they are measured cleanrooms and clean zones cleaning and decontamination cleanroom clothing the impact of people on cleanliness. Intended as an introduction to the area of contamination control, the text is also an excellent source of knowledge for people with both theoretical and practical experience. The Swedish version has been used for a long time within the Nordic countries as a basic training textbook within the pharmaceutical, microelectronics, food and beverage, optics and many other industries.

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Based on the very successful German editions, this English version has been thoroughly updated and revised to reflect the developments of the last years and the latest innovations in the field. Throughout, the author makes excellent use of real-life examples and highly praised didactics to disseminate his expert knowledge needed by vacuum technology users and engineers in their daily work at industrial plants, as consultants or in design offices. He covers in detail the most modern liquid ring pumps, with chapters dedicated to maintenance, explosion prevention and general procedures for safety at work with this technology. The whole is backed by a large repository of frequently needed technical data, unit conversions, formulae and current industrial, technical and legal norms without drawing on unnecessary complex or theoretical mathematics. The result is the ideal hands-on introduction to vacuum technology, ranging from fundamentals to in-depth expert knowledge on liquid-ring vacuum pumps.

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