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This concise yet comprehensive treatment of the effects of spaceflight on biological systems includes issues at the forefront of life sciences research, such as gravitational biology, immune system response, bone cell formation and the effects of radiation on biosystems. Edited by a leading specialist at the European Space Agency (ESA) with contributions by internationally renowned experts, the chapters are based on the latest space laboratory experiments, including those on SPACELAB, ISS, parabolic flights and unmanned research satellites. An indispensable source for biologists, medical researchers and astronautics experts alike. The results of Space flight experiments, ground controls and flight simulations pave the way for a better understanding of gravity reactions in various organisms down to molecular mechanisms. This publication marks also the beginning of a new Space flight era with the construction and exploitation of the International Space Station (ISS) which provides a platform for an in-depth continuation of experiments under weightlessness in Low Earth Orbit and beyond.

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Contamination control is being used by more and more industries where the highest level of cleanliness and hygiene is of vital importance. This book covers the basic principles of contamination control and cleanroom technology from a holistic point of view. It deals with cleanliness and hygiene and their effects on the outcome of a process, reflecting the latest results from both scientific and practical points of view. The following topics are covered: contaminants and how they are measured cleanrooms and clean zones cleaning and decontamination cleanroom clothing the impact of people on cleanliness. Intended as an introduction to the area of contamination control, the text is also an excellent source of knowledge for people with both theoretical and practical experience. The Swedish version has been used for a long time within the Nordic countries as a basic training textbook within the pharmaceutical, microelectronics, food and beverage, optics and many other industries.

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Based on the very successful German editions, this English version has been thoroughly updated and revised to reflect the developments of the last years and the latest innovations in the field. Throughout, the author makes excellent use of real-life examples and highly praised didactics to disseminate his expert knowledge needed by vacuum technology users and engineers in their daily work at industrial plants, as consultants or in design offices. He covers in detail the most modern liquid ring pumps, with chapters dedicated to maintenance, explosion prevention and general procedures for safety at work with this technology. The whole is backed by a large repository of frequently needed technical data, unit conversions, formulae and current industrial, technical and legal norms without drawing on unnecessary complex or theoretical mathematics. The result is the ideal hands-on introduction to vacuum technology, ranging from fundamentals to in-depth expert knowledge on liquid-ring vacuum pumps.

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A range of alternative mechanisms can usually be postulated for most organic chemical reactions, and identification of the most likely requires detailed investigation. Investigation of Organic Reactions and their Mechanisms will serve as a guide for the trained chemist who needs to characterise an organic chemical reaction and investigate its mechanism, but who is not an expert in physical organic chemistry. Such an investigation will lead to an understanding of which bonds are broken, which are made, and the order in which these processes happen. This information and knowledge of the associated kinetic and thermodynamic parameters are central to the development of safe, efficient, and profitable industrial chemical processes, and to extending the synthetic utility of new chemical reactions in chemical and pharmaceutical manufacturing, and academic environments. Written as a coherent account of the principal methods currently used in mechanistic investigations, at a level accessible to academic researchers and graduate chemists in industry, the book is highly practical in approach. The contributing authors, an international group of expert practitioners of the techniques covered, illustrate their contributions by examples from their own research and from the relevant wider chemical literature. The book covers basic aspects such as product analysis, kinetics, catalysis, and investigation of reactive intermediates. It also includes material on significant recent developments, e.g. computational chemistry, calorimetry, and electrochemistry, in addition to topics of high current industrial relevance, e.g. reactions in multiphase systems, and synthetically useful reactions involving free radicals and catalysis by organometallic compounds.

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Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

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Field technicians and emergency response personnel are often faced with the dangers of flammable, combustible, and chemically unstable materials. Although there are numerous procedures set forth by regulatory agencies like the Occupational Safety and Health Administration (OSHA), the Environmental Protection Agency (EPA), and the National Institute for Occupational Safety and Health (NIOSH) for effectively and safely dealing with such environmental hazards, up until now there has been no single resource for training in this area. Based on the author's twenty-plus years of field experience, Hazardous Waste Operations and Emergency Response Manual is a comprehensive text that covers the complete curriculum requirements set forth by OSHA and HazWOPER. Highly accessible and broad in focus, the book is equally useful as a technical resource for training, a hands-on reference for field operations, and a textbook for environmental courses in a variety of areas. Coverage includes:Methods recommended by professional societies and regulatory agencies including the National Fire Protection Association, OSHA, EPA, and NIOSHPractical examples and assignments in each chapter to supplement the text and enhance usefulness to students.

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Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: the principles of solid phase organic synthesis electrophile and nucleophile cleavable linker units cyclative cleavage as a solid phase strategy photocleavable linker units safety-catch linker units enzyme cleavable linker units T1 and T2 –versatile triazene linker groups hydrazone linker units benzotriazole linker units phosphorus linker units sulfur linker units selenium and tellurium linker units sulfur, oxygen and selenium linker units cleaved by radical processes silicon and germanium linker units boron and stannane linker units bismuth linker units transition metal carbonyl linker units linkers releasing olefins or cycloolefins by ring-closing metathesis fluorous linker units solid-phase radiochemistry The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis. Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.

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This comprehensive yet concise book provides a thorough and complete guide to every aspect of managing the peer review process for scientific journals. Until now, little information has been readily available on how this important facet of the journal publishing process should be conducted properly. Peer Review and Manuscript Management in Scientific Journals fills this gap and provides clear guidance on all aspects of peer review, from manuscript submission to final decision. Peer Review and Manuscript Management in Scientific Journals is an essential reference for science journal editors, editorial office staff and publishers. It is an invaluable handbook for the set-up of new Editorial Offices, as well as a useful reference for well-established journals which may need guidance on a particular situation, or may want to review their current practices. Although intended primarily for journals in science, much of its content will be relevant to other scholarly areas. ?This wonderful work by Dr. Hames can be used as a textbook in courses for both experienced and novice editors, and I trust that it is what Dr. Hames intended when she prepared this beautiful book. Every scientific editor should read it.? Journal of Educational Evaluation for Health Professionals, 2008 This book is co-published with the Association of Learned and Professional Society Publishers (ALPSP) (www.alpsp.org) ALPSP members are entitled to a 30% discount on this book.

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The TMS320C6x is Texas Instrument's next generation DSP found in over 60 percent of wireless devices from leading manufacturers such as Ericsson, Nokia, Sony, and Handspring Author has many years experience working with the TI line of TMS DSPs and his books are based on courses and seminars given at TI sponsored meetings All programs listed in the text will be available on the Wiley FTP site In addition to its wireless applications, the TMS DSP is tailored to enable a new generation of Internet media entertainment appliances

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As the industry environment transforms from a completely regulated setting to a broader, deregulated marketplace, new market participants must understand planning and operations of power systems to effectively participate in markets. This industry overview provides a description of utility operations and traditional planning, and then explains asset management, investment analysis, and risk management within the context of a market environment. Written to provide a broad, working knowledge of the industry, Electric Power Planning for Regulated and Deregulated Markets: Includes descriptions of generation and transmission network equipment Provides an overview of the regulatory framework, system design and systems operations for ensuring reliable delivery of power Presents system planning across different time horizons with the objective of minimizing power production costs Explains the principles and architecture of a market environment coupling operational imperatives with financial transactions Addresses approaches of various participants, including power producers, retailers, and integrated energy companies toward bidding in day ahead markets, managing risks in forward markets, portfolio development and investment analysis Provides numerous examples addressing cost minimization, price forecasting, contract valuation, portfolio risk measurement and others Examines past news events and explains what went wrong at Three Mile Island, the Northeast blackout of 2003, and the California energy crisis This is an ideal reference for professionals in the public and private power service sectors such as engineers, lawyers, systems specialists, economists, financial analysts, policy analysts, and applied mathematicians.

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