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The leading guide to vulval diseases The newly updated Fourth Edition of Ridley’s The Vulva delivers a practical guide to diagnosing and treating common and uncommon conditions affecting the vulva. The book bridges across the different specialties involved in the study of vulval diseases, offering full colour pictures, a companion website, and a digital companion text. This newest edition provides the most up-to-date guidance on the diagnosis and management of vulval diseases, with extensively revised chapters and brand-new material on paediatric vulval disease, female genital mutilation, and psychological interventions. Finally, a variety of new clinical and histological images are included. The book also provides: A thorough introduction to the basics of vulval disease, including vulval embryology and anatomy, normal vulval microbiology and physiology, and the principles of medical treatment Comprehensive summaries of vulval infections, including herpes simplex, HPV, candidiasis, and ectoparasite infections Practical discussions of all vulval dermatoses, including genetic conditions, and signs of associated systemic disease In-depth information on vulvodynia Discussion of benign, pre-malignant and malignant lesionsPerfect for dermatology, gynecology, pathology, paediatrics, genito-urinary and urology consultants and trainees, Ridley’s The Vulva will also earn a place in the libraries of general practitioners and specialist nurses.

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DRUG TRANSPORTERS [b]Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques. The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. Reflects the current state of the field and offers perspectives on future directions Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science Provides up-to-date information on drug transporter families, mechanisms, and clinical implications Includes extensive references and numerous figures and tables throughout Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.

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Animal Welfare An Accessible Overview of the Concept of Sentience Throughout the Animal Kingdom and Why It Matters to Humans Animal Welfare explores the concept of sentience and the development of sentient minds throughout the animal kingdom. The work provides improved definitions and analysis of the ideas of sentience, cognition, and consciousness, along with evidence of advanced mental formulation in birds, fish, and invertebrates. Considerations between humans and animals are also discussed, such as outcome-based ethics in relation to humans’ duties of care and the rights and wrongs of domestication. The work is divided into three parts and covers key topics such as: Specifics of animal sentience, from pain and suffering, to fear and dread, all the way to animals’ social life and the comfort/joy/hope/despair they experience What we know about the sentience of different classes of animals in the waters, air, savannah/plains, and forests Considerations on human interactions based on animal sentience, including death (killing), animal farms, animals in laboratories, wild animals in captivity, and animals in sports and entertainment Analysis on what humans can learn from animals based on what we know about their varying levels of sentience Animal Welfare serves as an invaluable analysis of animal sentience for students, teachers, and professionals directly involved in the study, teaching, and applications of animal behavior, motivation, and welfare. Thanks to the wide-ranging implications of animal sentience, the work will also appeal to everyone with a broader interest in animal behavior and human/animal interactions.

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Methodologies and Challenges in Forensic Linguistic Casework Discover more about Forensic Linguistics, a fascinating cross-disciplinary field from an international team of renowned contributors Methodologies and Challenges in Forensic Linguistic Casework provides an overview of the range of forensic linguistic casework typically found in investigative and judicial contexts. In these case studies, the authors demonstrate how linguistic theory is applied in real-life forensic situations and the constraints and challenges they have to deal with. Drawing on linguistic expertise from the USA and Europe involving casework in English, Spanish, Danish and Portuguese, our contributing practitioners exemplify the most common types of text analysis such as identifying faked texts, suspect profiling, analyzing texts whose authorship is questioned, and giving expert opinions on meaning and understanding. Methodologies and Challenges in Forensic Linguistic Casework is designed for investigators and legal practitioners interested in the use of language analysis for investigative or evidentiary purposes, as well as for students and researchers wanting to understand how linguistic theory and analysis may be applied to solving real-life forensic problems using current best practice.

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