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Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular calcium, through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic, reveals: The pathway of discovery and invention of intracellular calcium over more than 100 years. The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells How the components required for calcium signalling are named and classified. The ingenious technology, which has been developed to study intracellular calcium. How calcium is regulated inside cells and how it works to trigger an event. The role of intracellular calcium in disease, cell injury and cell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of many natural toxins. How the intracellular calcium signalling system has evolved over 4000 million years, showing why it was crucial to the origin of life. A key principle presented throughout the book is the molecular variation upon which the intracellular calcium signalling system depends. This variation occurs within the same cell type and between cells with different functions, providing the invisible matrix upon which Darwin and Wallace’s Natural Selection depends. Featuring more than 100 figures, including detailed chemical structures as well as pictures of key pioneers in the field, a bibliography of more than 1500 references, as well as detailed subject and organism indices, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond.

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Study design and statistical methodology are two important concerns for the clinical researcher. This book sets out to address both issues in a clear and concise manner. The presentation of statistical theory starts from basic concepts, such as the properties of means and variances, the properties of the Normal distribution and the Central Limit Theorem and leads to more advanced topics such as maximum likelihood estimation, inverse variance and stepwise regression as well as, time-to-event, and event-count methods. Furthermore, this book explores sampling methods, study design and statistical methods and is organized according to the areas of application of each of the statistical methods and the corresponding study designs. Illustrations, working examples, computer simulations and geometrical approaches, rather than mathematical expressions and formulae, are used throughout the book to explain every statistical method. Biostatisticians and researchers in the medical and pharmaceutical industry who need guidance on the design and analyis of medical research will find this book useful as well as graduate students of statistics and mathematics with an interest in biostatistics. Biostatistics Decoded: Provides clear explanations of key statistical concepts with a firm emphasis on practical aspects of design and analysis of medical research. Features worked examples to illustrate each statistical method using computer simulations and geometrical approaches, rather than mathematical expressions and formulae. Explores the main types of clinical research studies, such as, descriptive, analytical and experimental studies. Addresses advanced modeling techniques such as interaction analysis and encoding by reference and polynomial regression.

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The second edition of Environmental Ethics combines a strong theoretical foundation with applications to some of the most pressing environmental problems. Through a mix of classic and new essays, it discusses applied issues such as pollution, climate change, animal rights, biodiversity, and sustainability. Roughly half of the selections are original essays new to this edition. Accessible introduction for beginners, including important established essays and new essays commissioned especially for the volume Roughly half of the selections are original essays new to this edition, including an entirely new chapter on Pollution and climate change and a new section on Sustainability Includes new material on ethical theory as a grounding for understanding the ethical dimensions of the environment, our interactions with it, and our place in it The text incorporates helpful pedagogy, including extensive editorial material, cases, and study questions Includes key information on recent developments in the field Presents a carefully selected set of readings designed to progressively move the reader to competency in subject comprehension and essay writing

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The second edition of Medical Ethics deals accessibly with a broad range of significant issues in bioethics, and presents the reader with the latest developments. This new edition has been greatly revised and updated, with half of the sections written specifically for this new volume. An accessible introduction for beginners, offering a combination of important established essays and new essays commissioned especially for this volume Greatly revised – half of the selections are new to this edition, including two essays on genetic enhancement and a section on gender, race and culture Includes new material on ethical theory as a grounding for understanding the ethical dimensions of medicine and healthcare Now includes a short story on organ allocation, providing a vivid approach to the issue for readers Provides students with the tools to write their own case study essays An original section on health provides a theoretical context for the succeeding essays Presents a carefully selected set of readings designed to progressively move the reader to competency in subject comprehension and essay writing

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Cyber Security features articles from the Wiley Handbook of Science and Technology for Homeland Security covering topics related to cyber security metrics and measure and related technologies that meet security needs. Specific applications to web services, the banking and the finance sector, and industrial process control systems are discussed.

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Transportation Security features articles from the Wiley Handbook of Science and Technology for Homeland Security covering topics related to security challenge of transportation systems in the USA and elsewhere, performance measures, including coverage of critical supply chain protection and emergency evacuation.

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Since the middle of the 20th Century yield design approaches have been identified with the lower and upper bound theorem of limit analysis theory – a theory associated with perfect plasticity. This theory is very restrictive regarding the applicability of yield design approaches, which have been used for centuries for the stability of civil engineering structures. This book presents a theory of yield design within the original “equilibrium/resistance” framework rather than referring to the theories of plasticity or limit analysis; expressing the compatibility between the equilibrium of the considered structure and the resistance of its constituent material through simple mathematical arguments of duality and convex analysis results in a general formulation, which encompasses the many aspects of its implementation to various stability analysis problems. After a historic outline and an introductory example, the general theory is developed for the three-dimensional continuum model in a versatile form based upon simple arguments from the mathematical theory of convexity. It is then straightforwardly transposed to the one-dimensional curvilinear continuum, for the yield design analysis of beams, and the two-dimensional continuum model of plates and thin slabs subjected to bending. Field and laboratory observations of the collapse of mechanical systems are presented along with the defining concept of the multi-parameter loading mode. The compatibility of equilibrium and resistance is first expressed in its primal form, on the basis of the equilibrium equations and the strength domain of the material defined by a convex strength criterion along with the dual approach in the field of potentially safe loads, as is the highlighting of the role implicitly played by the theory of yield design as the fundamental basis of the implementation of the ultimate limit state design (ULSD) philosophy with the explicit introduction of resistance parameters. Contents 1. Origins and Topicality of a Concept. 2. An Introductory Example of the Yield Design Approach. 3. The Continuum Mechanics Framework. 4. Primal Approach of the Theory of Yield Design. 5. Dual Approach of the Theory of Yield Design. 6. Kinematic Exterior Approach. 7. Ultimate Limit State Design from the Theory of Yield Design. 8. Optimality and Probability Approaches of Yield Design. 9. Yield Design of Structures. 10. Yield Design of Plates: the Model. 11. Yield Design of Plates Subjected to Pure Bending. About the Authors Jean Salençon is Emeritus Professor at École polytechnique and École des ponts et chaussées, ParisTech, France. Since 2009 he has been a member of the Administrative Board of CNRS (Paris, France). He has received many awards including the Légion d’Honneur (Commander), Ordre National du Mérite (Officer) and Palmes Académiques (Commander). His research interests include structure analysis, soil mechanics and continuum mechanics.

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Quantum networks build on entanglement and quantum measurement to achieve tasks that are beyond the reach of classical systems. Using quantum effects, we can detect the presence of eavesdroppers, raise the sensitivity of scientific instruments such as telescopes, or teleport quantum data from one location to another. Long-distance entanglement can be used to execute important tasks such as Byzantine agreement and leader election in fewer rounds of communication than classical systems, improving the efficiency of operations that are critical in distributed systems.

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This new edition of the ‘all in one' textbook for the postgraduate study of valuation on real estate courses retains its focus on the valuation and appraisal of commercial and industrial property across investment, development and occupier markets. It is structured from the client perspective and covers single-asset pricing, risk and return issues. The structure of the book has been substantially revised. Part A introduces the key microeconomic principles, focussing on land as a resource, production functions, supply and demand and price determination. The locational aspect of real estate is also introduced. Macroeconomic considerations are categorised by the main market sectors (and their function); the market for land (development), for space (occupation) and for money (investment). The economic context is set and the author then explains why property valuations are required and discusses the main determinants of value and how they might be identified. The mathematics required to financially quantify value determinants are also introduced. Part B of the book describes the methods of valuation; Part C applies these methods to the valuation of a range of property types for a wide variety of purposes; and Part D covers investment and development appraisal. The author introduces valuation activities from a broad economic perspective, setting valuation in its business finance context and combining its academic and practical roots. Changes in this second edition include: less daunting economics expanded companion website with PowerPoint slides for lecturers, self-test Questions & Answers for students: see www.wiley.com/go/wyattpropertyvaluation up-to-date case studies and sample valuations reference to the newly-published Red Book (the valuer’s bible) Property Valuation with its user-friendly format, using tried-and-tested teaching and learning devices and a clear writing style, remains the core text for students on real estate, estate management and land economy degree courses, as well as for fast-track conversion courses for non-cognate graduates.

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According to the NACFAM (National Council for Advanced Manufacturing USA) Sustainable Manufacturing is defined as the creation of manufactured products that use processes that are non-polluting, conserve energy and natural resources, and are economically sound and safe for employees, communities, and consumers. The book covers Sustainable Manufacturing techniques such as materials and manufacturing for renewable energies; clean manufacturing technology; ecological manufacturing; energy-efficient manufacturing; remanufacturing; recycling of materials; environmentally conscious design and manufacturing processes; sustainable advanced manufacturing systems; manufacturability in sustainable product design; education and training for sustainable manufacturing.

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