LITMIR.BIZ

This book is the perfect link for learning how to perform the experiments after only having studied theory. In eight chapters more than 50 essential NMR experiments are described in detail. Special focus is put on the organic set of NMR spectra (1H, 13C-APT, COSY, NOESY, HSQC and HMBC). Different chapters deal with advanced organic NMR, selective methods, heteronuclear NMR, relaxation and diffusion measurements, organic applications and maintenance. Every experiment has a section providing the reader with the purpose and scope of the specific experiment. Every experiment is concluded with the spectrum as it is obtained under the conditions described. Questions and comments enable the reader to check their understanding. The authors are very experienced and the whole book is in full color, which enhances the reading experience and makes the spectra and other figures easier to understand. This book is strongly recommended for all students and researchers who are involved in the structural elucidation of chemical compounds both in practical education and in pursuing research, in particular if they handle an NMR spectrometer.

Подробнее

Dieses Buch bietet einen integrierten Ansatz fur ein gemeinsames Controlling von Marketing und Vertrieb und hilft, den Unternehmenserfolg auf dieser Basis deutlich zu steigern. Der erste Teil des Buchs erlautert den aktuellen Stand der Controllingpraxis, der zweite Teil definiert und beschreibt die sechs Dimensionen des Controllings, die fur den Bereich Marketing und Vertrieb relevant sind: Management, Organisation und Prozesse; Markt und Branche; Marketing- und Vertriebskonzept; Kunden und Lieferanten; Produkte und Leistungserstellungsprozesse; Performance Measurement und Auditing. Das Buch bietet eine Fulle von Tools, Kennzahlen und Checklisten, die nicht nur fur das Controlling selbst, sondern auch fur Marketing- und Vertriebsplanung, fur die Optimierung von Prozessen und die Ausrichtung von Strategien und die Definition von Marketing- und Vertriebszielen von hohem Nutzen sind. Es fordert ein ganzheitliches Verstandnis der Zusammenhange und erlautert klar die Erfolgsdeterminanten in Marketing und Vertrieb. Mit seinem hohen Praxisbezug richtet sich das Buch an – Praktiker in Unternehmen sowie Dozenten und Studenten mit Ausrichtung Marketing, Controlling, Vertrieb – Fuhrungskrafte, Marketing- und Vertriebsmanager, Controller – Entscheider im strategischen und operativen Bereich von Controlling, Marketing und Vertrieb – Dozenten und Studenten an Werbe- und Kommunikationsakademien.

Подробнее

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

Подробнее

This thoroughly updated version of the German authoritative work on self-organization has been completely rewritten by internationally renowned experts and experienced book authors to also include a review of more recent literature. It retains the original enthusiasm and fascination surrounding thermodynamic systems far from equilibrium, synergetics, and the origin of life, representing an easily readable book and tutorial on this exciting field. The book is unique in covering in detail the experimental and theoretical fundamentals of self-organizing systems as well as such selected features as random processes, structural networks and multistable systems, while focusing on the physical and theoretical modeling of natural selection and evolution processes. The authors take examples from physics, chemistry, biology and social systems, and include results hitherto unpublished in English. The result is a one-stop resource relevant for students and scientists in physics or related interdisciplinary fields, including mathematical physics, biophysics, information science and nanotechnology.

Подробнее

Scientific and technical knowledge for measurements in modern electromagnetism must be vast as our electromagnetic environment covers all frequencies and wavelengths. These measurements must be applied to fields as varied as nanotechnologies, telecommunications, meteorology, geolocalization, radioastronomy, health, biology, etc. In order to cover the multiple facets of the topic, this book sweeps the entire electromagnetic spectrum, from several hertz to terahertz; considers distances ranging from nanometers to light-years in optics; before extending towards the various measurement techniques using electromagnetic waves for various applications. This book describes these different facets in eleven chapters, each covering different domains of applications.

Подробнее

In recent years cellular pathology has become more closely involved in the direct management of patients with the introduction of molecular technologies and targeted therapies. Advanced Techniques in Diagnostic Cellular Pathology introduces students and professionals to these concepts and the key technologies that are influencing clinical practice today. Each chapter is carefully structured to introduce the very latest techniques and describe their clinical purpose, principle, method and application in cellular pathology. The advantages of various methods for preparing, observing and demonstrating cells and tissues employed to assist in diagnosis are explored, in addition to the use of quantitative methods in the detection and diagnosis of disease. Supplementary web-based material including annotated virtual microscope slides is available with the book. This is provided courtesy of i-Path Diagnostics Ltd and can be accessed online from their website www.pathxl.com Describes the very latest, emerging and established molecular aspects of diagnostic pathology. A clear, focused approach with each chapter containing a summary, a review of basic principles and clinical applications. Includes web-based annotated virtual microscope slides. Contributions from experienced practitioners contain numerous real-world examples illustrating the use of different diagnostic techniques, and their clinical relevance Written by a team of experienced practitioners this book will prove invaluable both to postgraduate biomedical science students who are training to be cellular pathologists and to professionals working in diagnostic and research laboratories as part of their continuing professional development.

Подробнее

Banish your fears of statistical analysis using this clearly written and highly successful textbook. Statistics for Veterinary and Animal Science Third Edition is an introductory text which assumes no previous knowledge of statistics. It starts with very basic methodology and builds on it to encompass some of the more advanced techniques that are currently used. This book will enable you to handle numerical data and critically appraise the veterinary and animal science literature. Written in a non-mathematical way, the emphasis is on understanding the underlying concepts and correctly interpreting computer output, and not on working through mathematical formulae. Key features: Flow charts are provided to enable you to choose the correct statistical analyses in different situations Numerous real worked examples are included to help you master the procedures Two statistical packages, SPSS and Stata, are used to analyse data to familiarise you with typical computer output The data sets from the examples in the book are available as electronic files to download from the book’s companion website in ASCII, Excel, SPSS, Stata and R Workspace formats, allowing you to practice using your own software and fully get to grips with the techniques A clear indication is provided of the more advanced or obscure topics so that, if desired, you can skip them without loss of continuity. New to this edition: New chapter on reporting guidelines relevant to veterinary medicine as a ready reference for those wanting to follow best practice in planning and writing up research New chapter on critical appraisal of randomized controlled trials and observational studies in the published literature: a template is provided which is used to critically appraise two papers New chapter introducing specialist topics: ethical issues of animal investigations, spatial statistics, veterinary surveillance, and statistics in molecular and quantitative genetics Expanded glossaries of notation and terms Additional exercises and further explanations added throughout to make the book more comprehensive. Carrying out statistical procedures and interpreting the results is an integral part of veterinary and animal science. This is the only book on statistics that is specifically written for veterinary science and animal science students, researchers and practitioners.

Подробнее

The completely updated step-by-step guide to¿capturing experiences in sketch format—regardless of artistic ability Recording your ideas and observations primarily in pictures instead of words can help you become more creative and constructive on the job, no matter what your level of artistic ability. Featuring completely new coverage of visual note-taking in a digital world, Visual Notes for Architects and Designers, Second Edition demonstrates how to make rapid, notational sketches that serve as visual records for future reference, as well as improve understanding and facilitate the development of ideas. It shows you how to expand your knowledge of a subject beyond what is gained through observation or verbal representation alone. You gain access to simple techniques for collecting, analyzing, and applying information. Crowe and Laseau examine the relationship between note-taking, visualization, and creativity. They give practical guidance on how to develop: Visual acuity—the ability to see more in what you experience Visual literacy—expressing yourself clearly and accurately with sketches Graphic analysis—using sketches to analyze observations Numerous examples demonstrate some of the many uses of visual notes. They help you develop a keener awareness of environments, solve design problems, and even get more out of lectures and presentations. The authors also discuss types of notebooks suitable for taking visual notes. If you want to develop your perceptual and creative skills to their utmost, you will want to follow the strategies outlined in Visual Notes for Architects and Designers, Second Edition. It is a valuable guide for architects, landscape architects, designers, and anyone interested in recording experience in sketch form.

Подробнее

The vulnerability of socio -ecosystem combines the probability of exposure to natural or anthropogenic pressure, sensitivity and resilience. This book presents a systemic view of the diversity of pressures and impacts produced by climate change and human actions. Erosion of biodiversity by changing ocean chemistry, the intensification of global change raises the problem of the adaptation of living resources.

Подробнее

This book presents a systematic review on traditional Arab herbal medicine including historical background, medical innovations introduced by Arab physicians, common roots of Arab medicine and western medicine, methodology of drug discovery and therapy in Arabic and Islamic medicine, a state-of-the-art description of traditional Arab herbal medicine, and evidence-based safety and efficacy of Arab and Islamic medicines. The usage of modern cell biological, biochemical, in vitro and in vivo techniques for the evaluation of medicinal plant safety and efficacy is also discussed. The toxicity of herbal formulations safety, quality assurances, and chemical analytical techniques are introduced in this book.

Подробнее