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      54. How are consistent High-throughput virtual screening definitions important?

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      55. Are customer(s) identified and segmented according to their different needs and requirements?

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      56. What is the context?

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      57. Is there a completed SIPOC representation, describing the Suppliers, Inputs, Process, Outputs, and Customers?

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      58. What information should you gather?

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      59. How was the ‘as is’ process map developed, reviewed, verified and validated?

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      60. What are the High-throughput virtual screening use cases?

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      61. Are there any constraints known that bear on the ability to perform High-throughput virtual screening work? How is the team addressing them?

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      62. What constraints exist that might impact the team?

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      63. What gets examined?

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      64. Has a High-throughput virtual screening requirement not been met?

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      65. Are different versions of process maps needed to account for the different types of inputs?

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      66. Do you have organizational privacy requirements?

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      67. Are stakeholder processes mapped?

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      68. What are the boundaries of the scope? What is in bounds and what is not? What is the start point? What is the stop point?

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      69. Is the team equipped with available and reliable resources?

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      70. Who is gathering High-throughput virtual screening information?

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      71. Are task requirements clearly defined?

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      72. Is full participation by members in regularly held team meetings guaranteed?

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      73. Is the improvement team aware of the different versions of a process: what they think it is vs. what it actually is vs. what it should be vs. what it could be?

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      74. What are the tasks and definitions?

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      75. What key stakeholder process output measure(s) does High-throughput virtual screening leverage and how?

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      76. Is the High-throughput virtual screening scope complete and appropriately sized?

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      77. Are the High-throughput virtual screening requirements complete?

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      78. Are audit criteria, scope, frequency and methods defined?

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      79. Has the direction changed at all during the course of High-throughput virtual screening? If so, when did it change and why?

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      80. How is the team tracking and documenting its work?

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      81. Is High-throughput virtual screening linked to key stakeholder goals and objectives?

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      82. What are the dynamics of the communication plan?

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      83. Is there a critical path to deliver High-throughput virtual screening results?

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      84. How do you manage scope?

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      85. What are the Roles and Responsibilities for each team member and its leadership? Where is this documented?

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      86. How do you gather High-throughput virtual screening requirements?

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      87. Do you have a High-throughput virtual screening success story or case study ready to tell and share?

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      88. Who defines (or who defined) the rules and roles?

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      89. What High-throughput virtual screening requirements should be gathered?

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      90. What information do you gather?

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      91. What sort of initial information to gather?

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      92. Are improvement team members fully trained on High-throughput virtual screening?

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      93. How do you think the partners involved in High-throughput virtual screening would have defined success?

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      94. Have the customer needs been translated into specific, measurable requirements? How?

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      95. Why are you doing High-throughput virtual screening and what is the scope?

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      96. Are there different segments of customers?

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      97. What customer feedback methods were used to solicit their input?

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      98. What baselines are required to be defined and managed?

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      99. Scope of sensitive information?

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      100. What would be the goal or target for a High-throughput virtual screening’s improvement team?

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      101. Is scope creep really all bad news?

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      102. What intelligence can you gather?

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      103. Has anyone else (internal or external to the group) attempted to solve this problem or a similar one before? If so, what knowledge can be leveraged from these previous efforts?

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      104. What is the definition of High-throughput virtual screening excellence?

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      105. Do the problem and goal statements meet the SMART criteria (specific, measurable, attainable, relevant, and time-bound)?

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      106. Is High-throughput virtual screening currently on schedule according to the plan?

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      107. Is there any additional High-throughput virtual screening definition of success?

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