Influence of FOX genes on aging and aging-associated diseases - Elena Tschumak

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the importance of FOXP3 in Alzheimer's disease, in with chronic inflammation leads to the development of myeloid plaques. This inflammation is caused by a loss of Foxp3 + regulatory T cells (Tregs). It would be interesting to investigate whether FOXP3 modulation plays a role in Alzheimer's disease, as it is the case with FOXO1 and FOXO3a. So FOX-miRNA modulation is involved in the progression of Alzheimer's disease. (Lau et al., 2013). This study „Alteration of the microRNA network during the progression of Alzheimer's disease“ observed the hippocampal miRNAs dysregulation of AD-patients. In them miR-132-3p expression on chromosome 17 was altered in both hemispheres. In AD stages III and IV it was severely decreased (41 persons with late-stage AD were compared to 23 healthy volunteers). This dysregulation was mainly observed in tau hyperphosphorylated neurons. This miRNA may affect both the TAU and the transcription factor FOXO1, whose expression is increased in the LOAD hippocampus. According to Wong et al. (2013), miR-132-3p also regulates FOXO3a, which in turn activates pro-apoptotic genes and is overexpressed in LOAD

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