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and vice versa, independent of the neuropsychological test being used.104 Using quantitative relations integrating BOLD responses, energetics and impulse firing, it has been shown how baseline activity can determine the amplitude of both positive and negative sustained BOLD signals.105 It may therefore be necessary to measure the ongoing activity in the area of interest in order to correct for the fMRI amplitude during the neuropsychological test. In animal studies this can be done by using PET to determine the ongoing glucose metabolism, a direct measure of activity, in conjunction with the fMRI measurements.106 This can be carried out using combined MRI/PET, but involves the injection of radioactive fluorodeoxyglucose as a ligand, a procedure that is invasive for human subjects. The extent that the baseline varies between different cortical areas of interest in the cortex is not clear at this time, so there are reservations concerning the interpretation of the amplitude of the BOLD signal recorded in different areas during a psychological test.107

       The existence of a ‘global BOLD signal’ across the cortex, and the question of the regression of the signal

      Notes

      1 1 For a history of the identification of sensory systems see M. R. Bennett, S. Hatton, D. F. Hermens and J. Lagopoulos, ‘Behaviour, neuropsychology and fMRI’, Progress in Neurobiology, 145–6 (2016), pp. 1–25.

      2 2 Aristotle, De Anima 412a20. Subsequent references to this treatise in the text will be flagged ‘DA’.

      3 3 It should be noted that Aristotle held that a sightless eye is no more an eye than a painted eye, just as a corpse is no more an animal than a statue.

      4 4 Note that when Aristotle says that we do these things with our soul, this is not like doing something with our hands or eyes, but rather like doing something with our talents and abilities.

      5 5 We disregard here the complexities, and incoherences, that arise with regard to Aristotle’ s distinction between the active and passive intellect and the intimation that the active intellect may be capable of existing without a body (DA 429a18–29, 430a18–25). These passages were crucial for the later scholastic synthesis of Aristotelian philosophy of mind with Christian doctrine concerning the immortality of the soul.

      6 6 For his reasoning, see De Partibus Animalium 647a22–34. In this respect he differed from the Hippocratic tradition. The Hippocratic lecture on epilepsy noted that ‘It ought to be generally known that the source of our pleasure, merriment, laughter and amusement, as of our grief, pain, anxiety and tears, is none other than the brain. It is especially the organ which enables us to think, see and hear, and to distinguish the ugly and the beautiful, the bad and the good, pleasant and unpleasant… . It is the brain too which is the seat of madness and delirium, of the fears and frights which assail us, often by night, but sometimes even by day; it is there where lies the cause of insomnia and sleepwalking’ (‘The sacred disease’, §17, in G. E. R. Lloyd (ed.), Hippocratic Writings (Penguin Books, Harmondsworth, 1978). The Hippocratic insight is wonderful; the physiological reasoning is, however, no less erroneous than Aristotle’ s reasoning in support of his different hypothesis.

      7 7 Aristotle, De Somno 455a21. This is the Barnes translation; an alternative translation of the sentence in which this term appears is ‘For there exists a single sense-faculty, and the master organ is single’.

      8 8 His term is aisthe¯sis koine¯, which occurs only in De Anima 425a27, De Memoria 450a10 and De Partibus Animalium 686a27.

      9 9 Aristotle, De Sensu 449a5–11.

      10 10 See, e.g., F. Crick, The Astonishing Hypothesis (Touchstone, London, 1995), p. 22; A. Damasio, The Feeling of What Happens (Heinemann, London, 1999), p. 320; E. Kandel and R. Wurtz, ‘Constructing the visual image’, in E. R. Kandel, J. H. Schwartz and T. M. Jessell (eds), Principles of Neural Science (Elsevier, New York, 2001), p. 492. For a discussion of the binding problem, see §5.2.3.

      11 11 Aristotle, De Somno 455a15–20.

      12 12 e.g. L. Weiskrantz, Blindsight: A Case Study and Implications (Oxford University Press, Oxford, 1986); Weiskrantz, ‘Varieties of residual experiences’, Quarterly Journal of Experimental Psychology, 32 (1980), pp. 365–86. See §17.3.1.

      13 13 The argument is curious, inasmuch as it is unclear in what sense he thinks we discriminate white from sweet. To be sure, we possess the faculties to see white things and distinguish them from other coloured things, and to taste sweet things and distinguish them from things with other tastes, and we (language-users) also possess the concepts of white (and other colours) and sweet (and other gustatory qualities). But we do not discriminate white things from sweet things; nor do we need any further organ to differentiate white from sweet (for what would it be to confuse them?).

      14 14 Aristotle, De Somno 455a.

      15 15 Aristotle, De Memoria 450a9–14.

      16 16 Cicero, Tusculan Disputations 1.10.22, quoted by D. Furley, ‘Aristotle the philosopher of nature’, in D. Furley (ed.), From Aristotle to Augustine, vol. iv of Routledge History of Philosophy (Routledge, London, 1999), p. 16. Note that Cicero must surely be mistaken in ascribing to Aristotle the view that the soul is made of anything.

      17 17 Galenus, Hippocratis de natura hominis commentaria III, In Hippocratis de victu acutorum commentaria IV, De diaeta Hippocratis in morbis acutis, ed. J. Mewaldt (Teubner, Berlin/Leipzig, 1914), p. 70, 5–6.

      18 18 H. Von Staden, Herophilus (Cambridge University Press, Cambridge, 1989), pp. 155–6.

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