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The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

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Health assessment is central to effective planning, implementation and evaluation of nursing care. All nurses are accountable for the care they provide and need to be able to accurately determine patient needs in order to plan and deliver evidence-based care. Vital notes for nurses: Health assessment provides students with the knowledge required to consider the many different factors which can influence patient’s health, comfort, well-being and recovery and to confidently assess patient needs. Vital notes for nurses: Health assessment explores concepts of holism, health and illness, factors to consider when assessing patients, communication skills needed for assessment, and all aspects of holistic assessment including physical, psychological, social, cultural and spiritual factors and nutritional needs. * Provides a concise, accessible introduction to health assessment * Includes physical, psychological, social, cultural and spiritual health assessment * Explores essential concepts in assessment and care planning * Within the Vital Notes for Nurses series * Adopts a holistic approach

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The growth of biostatistics has been phenomenal in recent years and has been marked by considerable technical innovation in both methodology and computational practicality. One area that has experienced significant growth is Bayesian methods. The growing use of Bayesian methodology has taken place partly due to an increasing number of practitioners valuing the Bayesian paradigm as matching that of scientific discovery. In addition, computational advances have allowed for more complex models to be fitted routinely to realistic data sets. Through examples, exercises and a combination of introductory and more advanced chapters, this book provides an invaluable understanding of the complex world of biomedical statistics illustrated via a diverse range of applications taken from epidemiology, exploratory clinical studies, health promotion studies, image analysis and clinical trials. Key Features: Provides an authoritative account of Bayesian methodology, from its most basic elements to its practical implementation, with an emphasis on healthcare techniques. Contains introductory explanations of Bayesian principles common to all areas of application. Presents clear and concise examples in biostatistics applications such as clinical trials, longitudinal studies, bioassay, survival, image analysis and bioinformatics. Illustrated throughout with examples using software including WinBUGS, OpenBUGS, SAS and various dedicated R programs. Highlights the differences between the Bayesian and classical approaches. Supported by an accompanying website hosting free software and case study guides. Bayesian Biostatistics introduces the reader smoothly into the Bayesian statistical methods with chapters that gradually increase in level of complexity. Master students in biostatistics, applied statisticians and all researchers with a good background in classical statistics who have interest in Bayesian methods will find this book useful.

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This pocket reference and revision guide is a must for all medical students and junior doctors preparing for major exams in clinical medicine or needing a rapid reminder of essential facts during a clinical attachment. Now thoroughly updated, this new edition combines the first editions of Rapid Medicine and Rapid Differential Diagnosis and contains reference to over 200 common medical conditions and diseases and 350 signs and symptoms encountered on a daily basis on the wards, in clinics and in exams. This concise, no-nonsense reference is presented in an A-Z format for easy access to information, and includes a thematic index with conditions sorted by speciality making it an ideal companion in any clinical situation.

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This book is part of the AHA Clinical Series published in conjunction with the American Heart Association in order to focus on high-interest and emerging topics in cardiovascular disease targeted for cardiologists and other interested healthcare providers. Cardiogenic shock causes over half of the deaths among patients hospitalized with ST-elevation myocardial infarction worldwide. Therefore, its management is one of the most important aspects of the care of patients with acute MI. Yet there is no single comprehensive source for information about this problem in the modern era; this book fills that gap. Drs. Hochman and Ohman offer an extremely useful tool for investigating, evaluating, and treating one of the most important lingering challenges in acute cardiovascular care.

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Neuroimaging in Addiction presents an up-to-date, comprehensive review of the functional and structural imaging human studies that have greatly advanced our understanding of this complex disorder. Approaching addiction from a conceptual rather than a substance-specific perspective, this book integrates broad neuropsychological constructs that consider addiction as a neuroplastic process with genetic, developmental, and substance-induced contributions. The internationally recognized contributors to this volume are leaders in clinical imaging with expertise that spans the addiction spectrum. Following a general introduction, an overview of neural circuitry and modern non-invasive imaging techniques provides the framework for subsequent chapters on reward salience, craving, stress, impulsivity and cognition. Additional topics include the use of neuroimaging for the assessment of acute drug effects, drug-induced neurotoxicity, non-substance addictive behaviors, and the application of imaging genetics to identify unique intermediate phenotypes. The book concludes with an exploration of the future promise for functional imaging as guide to the diagnosis and treatment of addictive disorders. Scientists and clinicians will find the material in this volume invaluable in their work towards understanding the addicted brain, with the overall goal of improved prevention and treatment outcomes for patients. Features a Foreword by Edythe London, Director of the Center for Addictive Behaviors, University of California at Los Angeles.

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Lecture Notes: Urology is a best-selling concise introduction to urology, presenting the essential core knowledge for medical students and junior doctors. It emphasises clinical presentations and diagnostic problem-solving, providing an integrated approach to understanding the renal system and urinary tract. This new edition has been fully revised and re-written with a new format, design and artwork, and now includes a section on interstitial brachytherapy for early prostate cancer and laparoscopic radical prostatectomy, coverage of imaging and surgical techniques, and a self-assessment section of MCQs. It explains all the important aspects of urology in a simple, clearly written and concise way, with a comprehensive overview of normal structure and function, and guidance on the specifics of history and examination relevant to this body system. It systematically covers the pathology of the diseases which affect normal function, explaining the principles of treatment and management. Lecture Notes: Urology will prove invaluable as a well-balanced introduction to urology and a rapid revision guide for final exams for junior doctors, medical students and allied health professionals. Reviews of the previous edition «…this work provides a highly comprehensive and approachable guide to urology.» British Journal of Surgery «…there is much to recommend in this book for undergraduates and there is no doubt that it will be widely read by medical students.» British Journal of Urology «A very comprehensive and detailed account of urology for medical students. Good diagrams, well thought out presentation and style and a layout very friendly to the reader.» Cambridge Medicine Titles of related interest The Renal System at a Glance, Third Edition O'Callaghan September 2009 9781405184724 Nephrology: Clinical Cases Uncovered Clatworthy Forthcoming 9781405189903

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The first edition of this text, edited by two of the world’s most respected pediatric cardiologists, set the standard for a single-volume, clinically focused textbook on this subject. This new edition, revised and updated by contributors representing today’s global thought leaders, offers increased coverage of the most important current topics, such as pediatric electrophysiology, congenital heart disease, cardiovascular genetics/genomics, and the identification and management of risk factors in children, while maintaining the clinical focus. Published with a companion website that features additional images for download, self-assessment questions designed to aid readers who are preparing for examinations, and other features, Pediatric Cardiovascular Medicine, Second Edition, is the perfect reference for residents, fellows, pediatricians, as well as specialists in pediatric cardiology.

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This comprehensive book captures and compiles new and current information on hematologic malignancies. New knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic and genomic changes has influenced the current outlook toward haematological malignancies. This recent and ongoing expansion of knowledge on malignant hematology has not previously been utilized to its full capacity due to its diffuse distribution scattered over the internet and research publications. This book is written by experts from the American and European continent, sharing their current thoughts and knowledge on the pathobiology of malignant haematological diseases of the blood, as well as current treatment strategies and future developments in the area of these haematological diseases.

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Now in its sixth edition, this highly-regarded book is designed as an introductory text on the principles of diagnosis, staging and treatment of tumours. The new edition: Includes up-to-date information on the most recent techniques and therapies available Emphasises the importance of multidisciplinary teamwork in the care of cancer patients Highlights frequent dilemmas and difficulties encountered during cancer management Features the important contributions of a new author Professor Daniel Hochhauser Contains a brand-new two-colour design As with previous editions, the first part of the book is devoted to the mechanisms of tumour development and cancer treatment. This is followed by a systematic account of the current management of individual major cancers. For each tumour there are details of the pathology, mode of spread, clinical presentation, staging and treatment with radiotherapy and chemotherapy. This accessible and practical resource will be invaluable to trainees in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and professions allied to medicine. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.

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