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The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

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Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.

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Dieses Handbuch kombiniert das gesamte Wissen, das fur erfolgreiches Bierbrauen benotigt wird: von der Auswahl der Rohstoffe bis zur garfahigen Wurze. Zahlreiche Tabellen und Abbildungen, die die technischen Details veranschaulichen, machen dieses Buch zum ultimativen Nachschlagewerk. Der Handbuch-Klassiker der beiden beruhmten Bierbrauer Ludwig Narziss und Werner Back liegt endlich uberarbeitet und erganzt als Neuauflage vor.

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This concise introductory textbook uses carefully chosen examples from clinical and experimental observations to provide an insight into the principles underlying the immune system. As a result, it encourages readers to ask critical questions in order to further advance our understanding of this unique organ. Both authors are experienced lecturers and highly regarded researchers. The book is professionally illustrated in four color throughout with beautiful artwork which by itself distinguish the title from any comparable title. Website: www.wiley-vch.de/home/immunology

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The Handbook of English Pronunciation presents a comprehensive exploration of English pronunciation with essential topics for applied linguistics researchers and teachers, including language acquisition, varieties of English, historical perspectives, accent’s changing role, and connections to discourse, technology, and pedagogy. Provides thorough descriptions of all elements of English pronunciation Features contributions from a global list of authors, reflecting the finest scholarship available Explores a careful balance of issues and topics important to both researchers and teachers Provides a historical understanding of the importance of pronunciation and examines some of the major ways English is pronounced today throughout the world Considers practical concerns about how research and practice interact in teaching pronunciation in the classroom

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Reviews the latest research breakthroughs and applications Since the discovery of carbon nanotubes in 1991, one-dimensional nanostructures have been at the forefront of nanotechnology research, promising to provide the building blocks for a new generation of nanoscale electronic and optoelectronic devices. With contributions from 68 leading international experts, this book reviews both the underlying principles as well as the latest discoveries and applications in the field, presenting the state of the technology. Readers will find expert coverage of all major classes of one-dimensional nanostructures, including carbon nanotubes, semiconductor nanowires, organic molecule nanostructures, polymer nanofibers, peptide nanostructures, and supramolecular nanostructures. Moreover, the book offers unique insights into the future of one-dimensional nanostructures, with expert forecasts of new research breakthroughs and applications. One-Dimensional Nanostructures collects and analyzes a wealth of key research findings and applications, with detailed coverage of: Synthesis Properties Energy applications Photonics and optoelectronics applications Sensing, plasmonics, electronics, and biosciences applications Practical case studies demonstrate how the latest applications work. Tables throughout the book summarize key information, and diagrams enable readers to grasp complex concepts and designs. References at the end of each chapter serve as a gateway to the literature in the field. With its clear explanations of the underlying principles of one-dimensional nanostructures, this book is ideal for students, researchers, and academics in chemistry, physics, materials science, and engineering. Moreover, One-Dimensional Nanostructures will help readers advance their own investigations in order to develop the next generation of applications.

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The use of webcam, especially through Skype, has recently become established as one more standard media technology, but so far there has been no attempt to assess its fundamental nature and consequences. Yet webcam has profound implications for many facets of human life, from self-consciousness and intimacy to the sustaining of long-distance relationships and the place of the visual within social communications. Based on research in London and Trinidad, this book shows how 'always-on' webcam is becoming an entirely different phenomenon from the initial use of webcam as a videophone. Webcam is examined within the framework of 'polymedia' – that is, the new environments created by the simultaneous presence of a multiplicity of communication technologies – and used to exemplify a theory of attainment that accepts media technologies as aspects of, rather than detracting from, our basic humanity.

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Many families leave their children for years to be looked after by young people about whom they know next to nothing, from places they have barely heard of. Who are these au pairs, why do they come and what is their experience of this arrangement? Do they, for their part, find that they are treated as one of the family, and would they even want to be? After a year of careful research, this book shows how most of our assumptions and expectations about au pairs are wrong. This is the first book devoted to the lives of au pairs, their leisure as well as their work time. We see this world from the eyes of the visitors, and their unique perspective on what lies at the heart of our family life. The book does not flinch from documenting the realities of the situation Ð the racism and the problematic behaviour of the au pairs themselves, as much as the ignorance and exploitation they can be subject to. The book is a case study in how to come to feel modern life empathetically from the viewpoint of one of those many migrant groups we take for granted and rely on but rarely try to understand.

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This stimulating discussion of a rapidly developing field is divided into two parts. The first features tutorials in textbook style providing self-contained introductions to the various areas relevant to atom chip research. Part II contains research reviews that provide an integrated account of the current state in an active area of research where atom chips are employed, and explore possible routes of future progress. Depending on the subject, the length of the review and the relative weight of the 'review' and 'outlook' parts vary, since the authors include their own personal view and style in their accounts.

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This critique explodes the stereotypical assumption that men are more prone than women to aggression A cogent and holistic assessment of the theoretical positions and research concerning female aggression Examines the treatment, punishment and community response to female aggressive behavior Examines topics including sexual power, serial murder and the evolution of gendered aggression Treats female aggression in its own right rather than as a counterpart to male violence

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