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Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines.
This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates:


SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST)
SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE)
macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials)


Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.

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Rereleased for Star Trek: The Original Series ’ 50th Anniversary, this in-depth analysis of the groundbreaking TV show features an updated introduction by Robert J. Sawyer and foreword by David Gerrold Trekkies and Trekkers alike will get starry-eyed over this eclectic mix of essays on the groundbreaking original Star Trek, one of the most culturally impactful TV shows of the last 50 years. Star Trek scriptwriters D. C. Fontana, David Gerrold, Norman Spinrad, and Howard Weinstein, science fiction writers including Allen Steele and Lawrence Watt-Evans, and various academics share behind-the-scenes anecdotes, discuss the show’s enduring appeal and influence, and examine some of the classic features of the series.Inside:Communications and media theorist Paul Levinson shows how the unprecedented success of the “seventy-nine jewels” in syndication changed the way we look at television forever.Star Trek writer D. C. Fontana remembers Gene Roddenberry and what it was like on the set and behind the scenes.Hugo Award–winning author Allen Steele explores the strong science fiction tradition that made the show so great.Cultural theorist Eric Greene details the show’s complex dialogue with the Vietnam War, highlighting the evolving stances on interventionist politics.Science fiction novelist DON Debrandt contends that the famously logical Spock isn’t quite as rational as Star Trek’s writers would have you believe.Scientist Robert A. Metzger proves that Scotty’s ability to lie makes him the most valuable member of the Enterprise crew.Fanfiction author Melissa Dickinson explains why we still feel compelled to write our own stories about Kirk, Spock, and the rest of the show’s memorable characters.

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Order in the Court!Star Wars: the most significant, powerful myth of the twenty-first century or morally bankrupt military fantasy?Six films. Countless books. $20 billion in revenue. No one can question the financial value or cultural impact of the Star Wars film franchise. But has the impact been for the good?In Star Wars on Trial’s courtroom—Droid Judge presiding—Star Wars stands accused of elitist politics and sexism, religious and ethical lapses, the destruction of literary science fiction and science fiction film, and numerous plot holes and logical gaps.Supported by a witness list of bestselling science fiction authors, David Brin (for the prosecution) and Matthew Woodring Stover (for the defense) debate these charges and more before delivering their closing statements.The verdict? That’s up to you.Covering the films from A New Hope to The Force Awakens, Brin and Stover provide new forewords that explore the newest generation of Star Wars films and what JJ Abrams must do to live up to—or redeem—the franchise.

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From Cole's downfall and Phoebe's somewhat questionable fashion sense to the power of three in history and literature and a magical tourist's guide to the Halliwells's hometown of San Francisco, this clever, lighthearted essay collection offers a fun and funny look at the world of the WB hit series Charmed. Edited by New York Times bestselling author Jennifer Crusie, these accessible and entertaining essays apply the wit and insight of one of today's leading romance authors to the stylish, occasionally campy fan favorite known for its scandalous outfits, revolving door of love interests, and the magical mayhem of three otherwise normal sisters who must fight against evil as they deal with the challenges of everyday life.

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Explore the Stargate SG-1 universe as never before with the expertise and insight of noted professionals from a diverse range of fields: from archaeology to parasitology to science fiction, <I.STEPPING EM Stargateis a fascinating collection of essays that delve into every aspect of Stargate with the same humor and intellectual curiosity of the show itself.

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Pervasive and multidisciplinary, this insightful exploration discusses how and why this seminal work developed, and continues to grow, such a cult following. When&#160;Fight Club&#160;punched its way onto the scene a decade ago, it provided an unprecedented glimpse into the American male&#8217;s psyche and rapidly turned into a euphemism for a variety of things that should be &#147;just understood&#8221; and not otherwise acknowledged. Key to its success is the variety of lenses through which the story can be interpreted; is it a story of male anxiety in a metrosexual world, of ritual religion in a secular age, of escape from totalitarian capitalism, or the spiritual malaise induced by technologically-oriented society? Writers, conspiracy theorists, and philosophers are among those ready to talk about&#160;Fight Club&#8217;s ability to be all these and more.

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From the Dursleys as social commentary to a look at Snape's role in less than child-friendly fanfiction . . . from the parallels between Azkaban and Abu Ghraib to the role of religion at Hogwarts . . . from why Dumbledore had to die to why killing Harry never should have been part of Voldemort's plan to begin with . . . Mapping the World of the Sorcerer&#8217;s Apprentice offers a comprehensive look at the Harry Potter series through the eyes of leading science fiction and fantasy writers and religion, psychology, and science experts.This book has not been authorized by J. K. Rowling, Warner Bros. or anyone associated with the Harry Potter books or films.

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The constellation of characters and themes created in&#160;Angel, the popular&#160;Buffy the Vampire Slayer&#160;spin-off, are explored in this collection of essays. A vampire author, a sex expert, a TV critic, a science fiction novelist, and Buffy&#160;writer Nancy Holder provide essays examining the different issues relating to the series, including Angelus as the prototypical high school bully, Angel as victim, Wesley's many transformations, how Spike fits into&#160;Angel, the takeover of Wolfram & Hart, and Lindsey's moral center.

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Leading writers discuss, debate, and celebrate the legend of Superman in this anthology, contending that his legend is a truly American myth. Superman was an immigrant with little more than the clothes on his back and raised by simple farmers, absorbing their humble values. He always chose to do the right thing, fighting for truth, justice, and the American way, and represents America at its best. The in-depth analyses of the comics, films and cartoons are at turns funny, philosophical, insightful, and personal, exploring every aspect of the Superman legend.

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What is the XYZ factor?The XYZ Factor isn&#8217;t a place or a company or an age. It&#8217;s a new kind of culture where innovation, accessibility, and transparency are the norm. It&#8217;s an environment created on the principles of the Millennial generation to foster intergenerational productivity in a new kind of office culture. An XYZ organization&#8217;s employees are challenged, engaged, and excited to produce. Simply put, XYZ companies have an «it» factor that helps them rise above the competition.Any company can become an XYZ company. This book is your blueprint.Each chapter is written by a DoSomething.org staff member. Their firsthand experience with DoSomething.org, an organization that helps young people make the world suck less, gives them exceptional insights into working magic in the corporate world. And with over 3 million members and more than 200 active campaigns, such as collecting clothes for teenagers in homeless shelters, helping older adults learn to use technology, and creating anti-bullying comics, DoSomething.org is a standout organization&#151;not only for its message, but for the way it operates.When you open The XYZ Factor, you&#8217;re getting the recipe for the awesome sauce that has driven the success of the world&#8217;s largest organizations for young people and social change. This guidebook is your key to answering the questions your company has looming over its cubicles, such as:How do I create an office environment that fosters collaboration and creativity?How do I form the right partnerships that appeal to our brand and our audience?How do I authentically reach the Millennial generation?If you want to take your business or organization from okay to amazing, you need The XYZ Factor.

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