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up to the biggest one you are interested in (for example, 1 to 1000). Then, you cross off from the list all the multiples of 2, the first prime number (4, 6, 8 and so on, but not 2 itself), and check that the next lowest number not crossed off is prime (if it isn’t, you have made a mistake!). If it is, cross off all the multiples of that number (but not the number itself), and so on. Once you get to the end of the list, the numbers that have not been crossed off form the list of primes.

No. 3 THE EYE AS A PINHOLE CAMERA

      After the decline of classical civilization and before the European Renaissance, scientific knowledge was preserved and improved in the Arabic world. Greek texts were translated into Arabic and later from Arabic into Latin, which is how they became known to Europeans. But the Arabs also carried out original scientific work. The greatest scientist of the Middle Ages, the ‘Arabic Newton’, was Abu Ali al-Hassan ibn al-Haytham, known for short as Alhazen, who lived from about 965 to 1040 and carried out experiments in optics on either side of the year 1000. His influential book was published in Europe in Latin as Opticae Thesaurus (The Treasury of Optics) in 1572, five centuries after his death. It was a major influence on the ‘natural philosophers’ who started the scientific revolution in Europe.

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      © Science Source/Science Photo Library

      Abu Ali al-Hassan ibn al-Haytham (known as Alhacen, or Alhazen) (965–1040).

      Alhazen’s key insight was that sight is not the result of some influence reaching out from the eyes and sensing the world outside, but is caused by light entering the eye from outside. In his own words, ‘from each point of every coloured body, illuminated by any light, issue light and colour along every straight line that can be drawn from that point’. This was not an entirely original idea. Philosophers had discussed whether vision was caused by an outward influence (emission) or an inward influence (intromission) since the time of Euclid and Aristotle. But Alhazen put together a complete, coherent package of ideas which he then proved correct by experiments based on the idea of a ‘camera obscura’ (literally, a ‘dark room’; the Latin term is the source of our modern word camera). In a dark room with a heavily curtained window, if a tiny hole is made in the curtain on a sunny day an image of the outside world will be projected, upside down, on the wall opposite the window. The phenomenon had been known to the ancients, but Alhazen was the first person to describe it clearly and explain what is going on.

      Alhazen realized that light travels in straight lines. Light from the top of a tree in the garden outside the window of the camera obscura will go through the hole in the curtain to the bottom of the wall opposite. Light from the base of the tree will go through the hole and up to the top of the wall. Straight lines from other points on the tree, and from other objects outside the window, go through the hole in straight lines to corresponding places on the wall to make the image.

      He might have stopped there. Before Alhazen, those philosophers who thought about such things at all, such as Euclid and Aristotle, usually stopped at this stage, without actually doing experiments to test their ideas. They tried to persuade people that they were right by logic and reason, without getting their hands dirty (Archimedes, of course, was a notable, but rare, exception). What made Alhazen a real scientist was that he went a stage further. It was one thing to show how a camera obscura worked, but something else to prove that the eye works in the same way. A thousand years ago, many people would have assumed that living things were not subject to the same rules as inanimate objects. To test whether this was so, he took an eyeball from a bull, and carefully scraped away at the back of it, thinning it down until he could see on the back of the eyeball an image of what was in front of the eye, almost exactly like a tiny camera obscura. He had proved that light travels in straight lines, shown how a camera obscura works, and established that no mysterious life force is needed to explain vision, just the same physical laws that apply to non-living things. And he had done so using what became known (eventually) as the scientific method – thinking up ideas (hypotheses) about how the world works based on observation, then testing those ideas by experiment. Today, an idea that passes the experimental test is upgraded to the status of a theory, while those that fail the experimental test are discarded. As the twentieth-century physicist Richard Feynman pithily put it, ‘if it disagrees with experiment then it is wrong’. Because he understood this and put it in to practice, Alhazen was arguably the first modern scientist.

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      © Science Museum/Science & Society Picture Library

      Alhazen’s representation of the eye as a ‘camera’.

      Alhazen did much more than this. He wrote on a variety of scientific and mathematical topics, and his optical work alone filled seven books. He realized that light does not travel at infinite speed, although it is very fast, and he explained the illusion that a straight stick looks bent when one end is placed in water because light travels at different speeds in water and in air. He studied lenses and curved mirrors, working out how the curvature makes them focus light. But his place in history has been secured by how he worked as much as by what he studied. It was the true beginning of experimental science.

No. 4 DISSECTING THE HUMAN BODY

      The scientific Renaissance began in the middle part of the sixteenth century, and a significant marker is the year 1543, when Copernicus published his famous book De Revolutionibus Orbium Coelestium (On the Revolution of Celestial Bodies), displacing the Earth from its supposed special position in the Universe, and Andreas Vesalius published De Humani Corporis Fabrica (On the Structure of the Human Body), going some way towards displacing humankind from a supposed special position in the animal world. Copernicus’s story is well known, and he did not, strictly speaking, carry out experiments. But Vesalius is less well known, and deserves more attention than he often gets. He did carry out experiments – on human bodies.

      Vesalius was born in Brussels in 1514, but carried out his important work at the University of Padua (where he was Professor of Anatomy) in the late 1530s and early 1540s. Before that time, when human dissections were carried out (which was not very often), the actual cutting was done by barber-surgeons, who were little more (arguably less) than butchers. The professor would stand at a safe distance (literally without getting dirty) and lecture to students about what was being uncovered, using imagination as well as actual evidence. Vesalius changed all that. He carried out the dissections himself, showing as well as telling the students what was going on, and developing a much better understanding of the human body. He was helped by the civil authorities in Padua – in particular, the judge Marcantonio Contarini, who not only supplied him with the bodies of executed criminals but would time the executions to fit in with Vesalius’s need for a fresh cadaver for a lecture. This was in marked contrast to his time as a student in Paris, where Vesalius (like his fellow medical students) had been reduced to grave-robbing to get specimens for his studies.

      Before Vesalius, the accepted understanding of human anatomy had been handed down since ancient times, and was based on the work of the Romano-Greek physician Claudius Galenus (known as Galen). In the Middle Ages in Europe, it was thought that the ancients had been much wiser than contemporary people, and that they had superior knowledge which could not be emulated, much less exceeded. But this was wrong. Galen was an enthusiastic dissector, but most of his work was carried out on dogs, pigs, and monkeys, because human dissection was infra dig in the second century AD. So his description of the human body was often wildly inaccurate.

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