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from the contagion, mindful of the advice which they received through the public press, took very particular care of their cattle during this season of epizootia: they rubbed them over with a brush, and washed them at least once a day; they sheltered them from the inclemency of wind and rain; they took their milch cows, which until then they had kept shut up in unhealthy cow-houses, into the open air of the fields; they washed and fumigated the stables; they examined the quality of the fodder and of the other articles of food; they added marine salt to their drinking water, or poured salt water over their forage; and above all, they took care that no foreign animal commingled with their flocks and herds.

      Some physicians, on their side conscious of the duty which devolves upon them in such seasons of calamity, instead of resting satisfied with recommending remedies, betook themselves boldly to the work, and studied the disease experimentally in respect to its propagation and prevention.

      Thus, for instance, certain Dutch physicians, in 1754, wishing to know whether the morbid matter would transmit the disease by inoculation, made incisions in the necks of some oxen, cows and calves, inserting in the wound a little tow saturated with the morbid secretions discharged from the eyes and nostrils. This direct inoculation having been practised on seventeen animals, transmitted the disease to them all in the course of a few days.

      The English physicians having been made acquainted with these experiments, applied them to a more practical purpose, no longer to discover whether the disease could thus be transmitted (for that had been proved), but to find out (what was far more important) whether this fearful distemper could be prevented and kept off.

      Malcolm Flemming, in 1755, merely suggested the idea of inoculation as a preventive means, without proceeding to a course of experiments to ratify his opinion. He intimates his notion in the following terms: —

      "I apprehend that inoculation will stand the better chance of bringing on the distemper, if the subject it is performed on is as young as safety will permit, the vessels being then most absorbent, and the animal economy most easily put into disorder.

      "But even in case the inoculation of calves should be found so successful as universally to prevail, the method I recommend will not be altogether useless; for, by being properly modelled and adapted to circumstances, it may, I am persuaded, prevent contagion, and likewise act as a preparative in any epidemical affection of the inflammatory kind, not only in horned cattle, but likewise in all other quadrupeds that civil society may think worthy of preservation, and even in the human species."

      Layard, in 1757, devotes the seventh chapter of his work, "The Means to prevent the Infection," to the consideration of the preventive treatment, in which he says: —

      "No one will think of bringing the infection into any place free from it, merely for the sake of inoculating their cattle; but if the contagious distemper be in the neighbourhood of a herd, or break out so as to endanger the stock, the grazier or farmer may, by inoculating his cattle, with proper precautions, at least secure his stock, since he can house them before they fall sick, prepare them, and have due care taken, knowing the course of the distemper.

      "Sir William St. Quintin, the Rev. Dr. Fountayne, Dean of York, and other gentlemen have succeeded in inoculation: in Holland it has both failed and succeeded. These gentlemen all inoculated with matter taken from the running of the mouth, nose, or eyes. Professor Swenke mentions that the beast from which he took the matter was recovering from the distemper. A circumstance to be attended to is this: – had matter been taken after the crisis, from a tumour, boil, pimple, or scab, either on the back near the spine, or on the legs, the pus would have proved much more elaborated, subtle, and infecting than that which, flowing with the mucus of the nose, must necessarily be, in some degree, sheathed by this glutinous excretion, though I am well aware how putrid and acrid it is rendered by the disease.

      "That nothing may be omitted which in any shape can contribute to the success of inoculation, due attention should be paid to the constitution and state of the beast, no less in this practice on the cattle than on the human species. Undoubtedly the young, healthy, and strong bid fairer for a good issue than the old, sickly, and feeble; each of these different constitutions demand a particular treatment, even in the method of preparation; and however trifling it may seem to many – the urging a necessity of preparation – I will venture to affirm that I have seen excellent effects arising from a rational preparation, and fatal events from want of preparation. I have likewise been witness of unfavourable turns, merely from an injudicious preparation.

      "The beasts which are sanguine require moderate bleeding; those that have but a small share of blood must have none drawn. The strong must, besides moderate bleeding and purging, be kept on light diet, and their body kept open. Thus, scalded bran, mixed with their hay and chaff, will cool them. The weakly, and such as are inclined to scour, must be kept on dry fodder, and have peas and beans given them to strengthen them. A mess of malt, or a quart of warm ale, with a few spices, will be very suitable for them.

      "Whatever diseases the cattle may be affected with, if time will permit, they are first to be removed.

      "The cattle to be inoculated are first to be well washed, rubbed dry, and then curried, to remove all the filth from the hair and skin. Then they are to be placed in a spacious barn or stable, where the air is temperate and no cold can come to them. There they are to be prepared according to the direction already given, foddered with good sweet hay, and watered with clear spring water; and if the distemper be not near, they may be turned out into the air, near the barn or stable, and may stay there a few hours in the middle of the day.

      "When it appears that the cattle are in perfect health, free from any infection or disease, brisk and lively, neither costive nor scouring, and chewing their cud, then the operation may be safely undertaken, and henceforth they must be confined to the barn.

      "Since there is observed to follow the greatest flow of the contagious and putrid particles separated from the blood, wherever the infectious matter makes an impression at first, particular care must be taken not to inoculate near such vital parts as the heart and lungs, nor near the womb, if a cow with calf be inoculated; for, though rowels are properly applied in the dewlaps to draw off the pestilential humour from the breast, and in other cases beasts are frequently rowelled in the flanks, – yet, in this operation, as matter is inserted by these channels into the neighbouring vessels, those vital parts, or the womb, might become the chief seat of the disease, and the event prove fatal.

      "To prevent such accidents, human beings have been inoculated on the arms and legs, and now-a-days the arms are found sufficient. I would recommend that the cattle should be inoculated about the middle of the shoulders or buttocks, on both sides, to have the benefit of two drains. The skin is to be cut lengthways two inches, deep enough for the blood to start, but not to bleed much. In this incision is to be put a dossil or pledget of tow, dipped in the matter of a boil full ripe, opened in the back of a young calf recovering from the distemper. It may not be amiss to stitch up the wound, to keep the tow in, and let it remain forty-eight hours. Then the stitches are to be cut, the tow taken out, and the wound dressed with yellow basilicum ointment, or one made with turpentine and yolk of egg, spread on pledgets of tow. These dressings are to be continued during the whole illness, and till after the recovery of the beast, to promote the discharge; and then the wound may be healed with the cerate of lapis calaminaris, or any other.

      "On the third day after inoculation, the discolouring of the wound, whose lips appear grey and swollen, will be a sign that the inoculation has succeeded; but the beasts, as Professor Swenke informs us, did not fall ill till the sixth day, which answers exactly to the observations daily made in the inoculating of children. Yet the Professor adds that on the third day a costiveness came on, which was removed by giving each calf three ounces of Epsom salts.

      "No sooner do the symptoms of heaviness and stupidity appear than the beasts must have a light covering thrown over them, and at night fastened loosely. They must be rubbed morning and evening, and curried, till the boils begin to rise; warm hay-water and vinegar-whey must be given plentifully. Should the beasts require more nourishment, dry meat, such as cut hay, with a little bran, may be offered. I should be very cautious in giving milk-pottage, even after the boils and pimples had all come out, for fear of bringing on a scouring. However, this caution is proper, that whenever milk-pottage be given, the vinegar-whey is to be omitted for obvious

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