Managing Medical and Obstetric Emergencies and Trauma - Группа авторов

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dysfunction. This encourages anaerobic metabolism in tissues, promoting lactic acidosis.

      A study of severe maternal sepsis in the UK (2011–2012) identified genital tract infection (31%) and the organisim Escherichia coli (21%) to be the most common causes, followed by group A Streptococcus, group B Streptococcus, other streptococci and Staphylococcus. Risk factors for severe sepsis were if the woman was black or of other ethnic minority, primiparous, had a pre‐existing medical problem, had a febrile illness or were taking antibiotics in the 2 weeks preceding presentation, operative vaginal delivery or caesarean. Median time between delivery and sepsis was 3 days. Multiple pregnancy and group A Streptococcus were associated with progression to septic shock. In the women with group A streptococcal infection the progression of sepsis was often rapid. For each maternal sepsis death, 50 women had life‐threatening morbidity from sepsis.

      Group A Streptococcus is a common skin or throat commensal, carried asymptomatically by up to 30% of the population. It is easily spread and is responsible for streptococcal sore throat, a very common childhood condition. Worldwide, however, group A Streptococcus is still the most common cause of postpartum maternal death and can kill pregnant and recently pregnant women with devastating speed. The initial presentation can be vague and non‐specific, thus delaying treatment. Primary symptoms include myalgia, fever, mild confusion, dizziness and abdominal pain.

      Transmission in pregnant women is thought to be either through the blood stream with the throat as a portal of entry, or via the perineal route with translocation from colonisation in the vagina, even in the presence of an intact membrane, as bacteria can cross this apparent barrier. Translocation from the vagina may occur from nosocomial exposure at birth or via a caesarean section incision. Streptococcal infection has a seasonal rise in incidence between December and April in the northern hemisphere. The link between pregnant women and children with group A streptococcal sore throats is thought to be significant as a possible source of infection.

      In the past, there was an emphasis on the transmission of infection from care‐givers to women, much reduced since the advent of strict hygiene practices in hospitals. It is thought that raising public health awareness of the risks from family members and encouraging women to follow appropriate personal hygiene practices may be helpful in reducing transmission of infection; in particular, pregnant women should be encouraged to handwash both before and after using the toilet to avoid transmitting organisms from other household members.

      Minimising risk from infection in the antenatal period, by avoiding unnecessary vaginal examinations and paying attention to hygiene, may reduce the incidence of sepsis. Early recognition and increased surveillance of those at risk including careful assessment of postnatal mothers, especially those with prolonged rupture of membranes, ragged membranes or possible incomplete delivery of the placenta and women with uterine tenderness or enlargement, will help to identify women developing serious infection. Multiple presentations should be seen as a red flag and requires careful review with escalation to senior staff for assessment.

       Symptoms of sepsis may include:

       Feeling unwell, anxious or distressed

       Shivery or feverish

       Sore throat, cough or influenza‐like symptoms (pneumonia accounts for a significant number of admissions to the intensive care unit in pregnant women in the antenatal period)

       Rash (see Appendix 7.1 for weblink to assessment of pregnant woman reporting viral rash illness)

       Chest pain

       Vomiting and/or diarrhoea

       Abdominal pain, uterine and renal angle pain, and beware ‘after pains’ of a severity that is out of proportion to the known cause and not responding to usual analgesia

       Wound tenderness

       If pregnant may report reduced fetal movements

       Offensive vaginal discharge

       Persistent vaginal bleeding may be a sign of uterine sepsis

       Breast tenderness, suggesting mastitis

       Headache

       Unexplained physical symptoms

      A high index of suspicion and close surveillance will help in identifying women with early sepsis. When assessing a woman who is unwell, revisit the history and consider her clinical condition in addition to the modified early obstetric warning score (MEOWS) and do not be reassured by a single set of observations on the MEOWS chart (Knight et al., 2017). Chronic illness and immunosuppression are risk factors for sepsis. Immunosuppression puts a woman at higher risk of rapid deterioration from sepsis, and sepsis should be considered a likely cause when they are unwell.

      Source: Nutbeam T, Daniels R on behalf of the UK Sepsis Trust. © 2019 UK Sepsis Trust

      Monitor women who have red and amber flags with suspected sepsis continuously and record using a MEWS chart (NICE, 2016). The conscious level should also be monitored using ACVPU (alert, new confusion, responds to voice, responds to pain, unconscious). A sepsis care bundle must be applied in a structured and systemic way with urgency. The time to administration of antibiotics is a predictor of mortality in sepsis, do not delay and use local antibiotic prescribing guidance. Antiviral medication may also be appropriate. The woman must be continually reassessed and senior review is essential. Consider ‘declaring sepsis’, analogous to activation of the major obstetric haemorrhage protocol.

       You can think of it as:

       ‘3 in, 3 out”: fluids, antibiotics and oxygen in / catheter, lactate and blood cultures out.

      Initial blood tests include lactate – either arterial if there is evidence of hypoxia or a venous sample. Any woman in whom sepsis is

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