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href="#ulink_2fa6bda7-e5a0-512a-9671-03586535d035">Role of GLP1 receptor agonists Conclusions References 14 Cardiovascular Consequences Introduction Epidemiology Risk associations in people with the prevalent disease – obesity paradox or confounding? Genetics of obesity and cardiovascular outcomes Mechanisms Interventions: weight loss benefits in CV medicine Timing of weight loss benefits on metabolic versus ASCVD outcomes Summary References 15 Obstructive Sleep Apnea Sleep‐disordered breathing Sleep‐disordered breathing: epidemiology Sleep‐disordered breathing: clinical aspects Sleep disordered breathing: treatment Conclusion References 16 Obesity and Cancer General mechanisms linking obesity and cancer Colorectal cancer Breast cancer Stomach cancer Liver cancer Esophageal cancer Pancreatic cancer Ovarian cancer Intentional weight loss Early life risk factors for cancer Dietary characteristics Comprehensive integration of the evidence‐base Disclosure References

      11  4 Management of Adult Obesity 17 A Practical Approach to Contemporary Obesity Management Introduction Obesity Weight loss Weight control in the age of SARs‐CoV‐2 coronavirus (COVID‐19) Aims of obesity treatment Current obesity treatment options Where should these interventions be available/delivered? Summary Appendix A References 18 Dietary Management of Obesity Dietary treatment of obesity Energy deficit Energy density Low‐fat diets Plant‐based diets Mediterranean diets Low energy diets Partial meal replacement therapy Low carbohydrate or higher protein diets Ketogenic diets Very low energy (calorie) diets (VLEDs) Intermittent energy restriction The less restrictive dieting approach Ultra‐processed food Sugar sweetened beverages Basic principles Nutrition in practice Portion sizes and eating frequency Maintenance and/or success Clinical guidelines Conclusion References 19 The Behavioral Treatment of Obesity Behavioral treatment Components of behavioral treatment Dietary options for weight loss Physical activity Structure of behavioral treatment Short‐ and long‐term weight losses Strategies to improve long‐term weight losses New behavioral approaches Implementation

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