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Cell separation is an important process that occurs throughout the life cycle of a plant. It enables the radicle to emerge from the germinating seed, vascular tissue to differentiate, sculpturing of leaves and flowers to take place, pollen to be shed from the mature anther, fruit to soften, senescent and non-functional organs to be lost, and seeds to be shed. In addition to its intrinsic scientific interest, many of the developmental processes to which it contributes have importance for agriculture and horticulture. This is the first volume to focus exclusively on these processes and to link improvements in our scientific understanding with methods that may allow us to manipulate cell separation and adhesion to the benefit of the agricultural and horticultural industries. It will therefore be of interest to the experimental scientist and to those who wish to apply these techniques commercially.

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Evidence grows daily of the changing climate and its impact on plants and animals. Plant function is inextricably linked to climate and atmospheric carbon dioxide concentration. On the shortest and smallest scales, the climate affects the plant’s immediate environment and so directly influences physiological processes. At larger scales, the climate influences species distribution and community composition, as well as the viability of different crops in managed ecosystems. Plant growth also influences the local, regional and global climate, through the exchanges of energy and gases between the plants and the air around them. Plant Growth and Climate Change examines the major aspects of how anthropogenic climate change affects plants, focusing on several key determinants of plant growth: atmospheric CO2, temperature, water availability and the interactions between these factors. The book demonstrates the variety of techniques used across plant science: detailed physiology in controlled environments; observational studies based on long-term data sets; field manipulation experiments and modelling. It is directed at advanced-level university students, researchers and professionals across the range of plant science disciplines, including plant physiology, plant ecology and crop science. It will also be of interest to earth system scientists.

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Gene flow is not unique to genetically modified (GM) crops, but the possibility of the spread of transgenic DNA to wild and domesticated relatives raises a new set of issues for scientists and policymakers to consider. Unfortunately, we are still too often unable to quantify the risks of ecological damage associated with gene flow. This is due partly to the huge breadth of knowledge required to assemble a comprehensive risk assessment. For example, many scientists active in research on the mechanics of gene flow nevertheless lack a deep understanding of what is required to identify, characterise and assess ecological risk, and many of those who are aware of the risk assessment process and the framework used for legislation have insufficient knowledge of the reproductive biology, agricultural systems, modelling and ecological literature required to compile a balanced risk assessment. This book, set in the context of gene flow in general, considers the assessment, measurement and management of the risks of gene flow from GM plants, combining the expertise of all the various stakeholders. It is directed at researchers and professionals in plant molecular genetics and plant ecology, in both the academic and industrial sectors.

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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

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A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.

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This is the first book specializing in plasmids and their biomedical use, including all relevant aspects of production, applications, quality, and regulations. Readers will discover clinical applications for the wide range of preventive and therapeutic applications using plasmid DNA. The book describes modified vector systems based on plasmids, as well as the potency of genomic research and vector design by informatics. Using the example of fish vaccination, the application of DNA vaccination in veterinary health care is reviewed, followed by a detailed overview of plasmid production technology on an industrial scale. Finally, the book considers regulatory and quality assurance aspects of such new drugs plus thire market potential.

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Provides an overview of the rapidly evolving field of genomics with coverage of nucleic acid technologies, proteomics and bioinformatics. It includes chapters on applications in human health, agriculture and comparative genomics and also contains two chapters on the legal and ethical issues of genomics, a topic that is becoming increasingly important as genomics moves out of the laboratory into practical applications.

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This concise introduction to the fundamentals of biological treatment of wastewater describes how to model and integrate biological steps into industrial processes. The book first covers the chemical, physical and biological basics, including wastewater characteristics, microbial metabolism, determining stoichiometric equations for catabolism and anabolism, measurements of mass transfer and respiration rates and the aerobic treatment of wastewater loaded with dissolved organics. It the moves on to deal with such applications and technologies as nitrogen and phosphorus removal, membrane technology, the assessment and selection of aeration systems, simple models for biofilm reactors and the modeling of activated sludge processes. A final section looks at the processing of water and the treatment of wastewater integrated into the production process. Essential reading for chemists, engineers, microbiologists, environmental officers, agencies and consultants, in both academia and industry.

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Fruit flies are «little people with wings» goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which «define» humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

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Medicines from Animal Cell Culture focuses on the use of animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration and the culture of stem cells. Medicines from Animal Cell Culture: Provides comprehensive descriptions of methods for cell culture and nutrition as well as the technologies for the preservation and characterisation of both the cells and the derived products Describes the preparation of stem cells and others for use in cell-based therapies – an area of burgeoning research Includes experimental examples to indicate expected results Covers regulatory issues from the UK, the EU and the USA and reviews how these are developing around the world Addresses the key issues of standardisation and validation with chapters on GLP and GMP for cell culture processes Delivering insight into the exciting world of biological medicines and directions for further investigation into specific topics, Medicines from Animal Cell Culture is an essential resource for researchers and technicians at all levels using cell culture within the pharmaceutical, biotechnology and biomedical industries. It is of value to laboratory managers in these industries and to all those interested in this topic alike.

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