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New strategies and techniques for today's fast-paced discovery process Today, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery. The topics represent current industry benchmarks in specific drug discovery activities that deal with proteomics, biomarker discovery, metabonomic approaches for toxicity screening, lead identification, compound libraries, quantitative bioanalytical support, biotransformation, reactive metabolite characterization, lead optimization, pharmaceutical property profiling, sample preparation strategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry are interconnected * Discusses the uses and limitations of various types of mass spectrometry in various aspects of drug discovery * Prominently features analytical applications that require trace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples

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A comprehensive reference to noise and signal interference in optical fiber communications Noise and Signal Interference in Optical Fiber Transmission Systems is a compendium on specific topics within optical fiber transmission and the optimization process of the system design. It offers comprehensive treatment of noise and intersymbol interference (ISI) components affecting optical fiber communications systems, containing coverage on noise from the light source, the fiber and the receiver. The ISI is modeled with a statistical approach, leading to new useful computational methods. The author discusses the subject with the help of numerous applications and simulations of noise and signal interference theory. Key features: Complete all-in-one reference on the subject for engineers and designers of optical fiber transmission systems Discusses the physical principles behind several noise contributions encountered in the optical communications systems design, including contributions from the light source, the fiber and the receiver Covers the theory of the ISI for the binary signal, as well as noise statistics Discusses the theory and the mathematical models of the numerous noise components (such as optical noise, photodetection noise and reflection noise) Introduces the frequency description of the ISI and provides new calculation methods based on the characteristic functions Provides useful tools and examples for optimum design of optical fiber transmission networks and systems This book will serve as a comprehensive reference for researchers, R & D engineers, developers and designers working on optical transmission systems and optical communications. Advanced students in optical communications and related fields will also find this book useful.

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Broadband Optical Access and Fiber-to-the-Home (FTTH) will provide the ultimate broadband service capabilities. Compared with the currently well-deployed broadband access technologies of ADSL (Asymmetric Digital Subscriber Line) and Cable Modems, optical broadband access with Fiber-to-the-User’s home will cater for much higher speed access for new services. Broadband Optical Access Networks and Fiber-to-the-Home presents a comprehensive technical overview of key technologies and deployment strategies for optical broadband access networks and emerging new broadband services. The authors discuss network design considerations, new services, deployment trends and operational experiences, while explaining the current situation and providing insights into future broadband access technologies and services. Broadband Optical Access Networks and Fiber-to-the-Home: Offers a comprehensive, up-to-date introduction to new developments in broadband access network technologies and services. Examines the impact of research and development in photonics technologies on broadband access and FTTH. Covers ADSL, VDSL with FTTC (Fiber-to-the-Curb), Cable Modem over HFC (Hybrid-Fiber Coax) and Gigabit Ethernet. Discusses the roles of Broadband Wireless LAN and integrated FTTH/Wireless Broadband Access as well as Broadband Home Networks. Provides a global view of broadband network development, presenting different technical and system deployment approaches and strategic considerations for comparison. Gives insight into the worldwide broadband competition and the future of this technology. Broadband Optical Access Networks and Fiber-to-the-Home will be an invaluable resource for engineers in research and development, network planners, business managers, consultants as well as analysts and educators for a better understanding of the future of broadband in the field of telecommunications, data communications, and broadband multimedia service industries.

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Featuring the work of an international group of scholars, this volume covers the transport properties and Soliton models of Polyacetylene, development and application of the theory of Brownian Motion, the fading of memory during the regression of structural fluctuations, the breakdown of the Kramers Theory as a problem of correct modeling, and more.

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Experts in the field cover a wide range of theoretical and practical aspects of photodissociation and photoionization. This complete survey covers everything from laser isotope separation at the applied end to current theories of the quantum mechanics of photodissociation.

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Shows the diversity and sophistication of present knowledge of molecular collisions and the forces that govern their outcome, examining major aspects from the point of view of the potential surface. Covers such topics as angle dependent potentials, vibranic coupling, and branching ratios in simple atomic reactions.

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The Advances in Chemical Physics series provides the chemical physics and physical chemistry fields with a forum for critical, authoritative evaluations of advances in every area of the discipline. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.

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This text is the first of a two-volume work on molecule surface interactions addressing topics in chemical physics, surface science, physical chemistry, materials science, and electronics and semiconductor manufacture. As with the other titles in the Advances in Chemical Physics series, the chapters are written by an international group of contributors and cover a wide range of important issues in the field.

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How to use analysis and process control instruments in waste water treatment is described in this book. Practice-experienced authors provide easy to understand guidelines. Choosing the right equipment and interpreting results correctly is made easy.

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This is the fascinating, first-hand story of the groundbreaking invention by Nobel prizewinner Karl Ziegler and the patent fights between his research team at the Max Planck Institute of Carbon Research in Germany and the «giants» of the petrochemicals industry, such as Du Pont and Esso. The author joined Ziegler's group throughout the entire period, providing an entertaining case study of an innovative chemical discovery, presenting interesting historical as well as scientific information. An impressive example of the fights between academia and industry concerning patent rights and the economic utilization of academic research innovations.

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