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The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

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By considering three case study regions in Mexico during the Colonial era, Climate and Society in Colonial Mexico: A Study in Vulnerability examines the complex interrelationship between climate and society and its contemporary implications. Provides unique insights on climate and society by capitalizing on Mexico’s rich colonial archives Offers a unique approach by combining geographical and historic perspectives in order to comprehend contemporary concerns over climate change Considers three case study regions in Mexico with very different cultural, economic, and environmental characteristics

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Remotely-sensed images of the Earth's surface provide a valuable source of information about the geographical distribution and properties of natural and cultural features. This fully revised and updated edition of a highly regarded textbook deals with the mechanics of processing remotely-senses images. Presented in an accessible manner, the book covers a wide range of image processing and pattern recognition techniques. Features include: New topics on LiDAR data processing, SAR interferometry, the analysis of imaging spectrometer image sets and the use of the wavelet transform. An accompanying CD-ROM with: updated MIPS software, including modules for standard procedures such as image display, filtering, image transforms, graph plotting, import of data from a range of sensors. A set of exercises, including data sets, illustrating the application of discussed methods using the MIPS software. An extensive list of WWW resources including colour illustrations for easy download. For further information, including exercises and latest software information visit the Author's Website at: http://homepage.ntlworld.com/paul.mather/ComputerProcessing3/

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Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: «Neurodevelopment and Neurodegeneration» discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. «Putting It All Together» recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, «The Next Generation,» examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

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The new edition of this classic student text provides an up-to-date and comprehensive view of the major environmental issues facing the world today, and is an essential introduction to the past, present and future impact of humans on Earth. Explores the impact of humans upon vegetation, animals, soils, water, landforms, and the atmosphere. Updated extensively, with many new figures and up-to-date statistics. Four completely new chapters explore the ways in which global climate change may have an impact on Earth in the future. A new design makes the text even more accessible and easy to use. Visit www.blackwellpublishing.com/humanimpact to access the artwork from the book.

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This accessible, new reference work shows how and why RF energy is created within a printed circuit board and the manner in which propagation occurs. With lucid explanations, this book enables engineers to grasp both the fundamentals of EMC theory and signal integrity and the mitigation process needed to prevent an EMC event. Author Montrose also shows the relationship between time and frequency domains to help you meet mandatory compliance requirements placed on printed circuit boards. Using real-world examples the book features: Clear discussions, without complex mathematical analysis, of flux minimization concepts Extensive analysis of capacitor usage for various applications Detailed examination of components characteristics with various grounding methodologies, including implementation techniques An in-depth study of transmission line theory A careful look at signal integrity, crosstalk, and termination

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The first book on the subject. Written by an acknowledged expert in the field. The techniques discussed have important applications to wireless engineering. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department.

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The Method of Lines (MOL) is a versatile approach to obtaining numerical solutions to partial differential equations (PDEs) as they appear in dynamic and static problems. This method, popular in science and engineering, essentially reduces PDEs to a set of ordinary differential equations that can be integrated using standard numerical integration methods. Its significant advantage is that the analysis algorithms follow the physical wave propagation and are therefore efficient. This is because the fields on the discretisation lines are described by generalised transmission line (GTL) equations. With this formulation we have a connection to the well known transmission line theory and resulting in an easy understanding. The method of lines is a very accurate and powerful way to analyze electromagnetic waves, enabling a full-wave solution without the computational burden of pure finite element or finite difference methods. With Analysis of Electromagnetic Fields and Waves, Reinhold Pregla describes an important and powerful method for analyzing electromagnetic waves. This book: Describes the general analysis principles for electromagnetic fields. Includes applications in microwave, millimetre wave and optical frequency regions. Unifies the analysis by introducing generalised transmission line (GTL) equations for all orthogonal coordinate systems and with materials of arbitrary anisotropy as a common start point. Demonstrates a unique analysis principle with the numerical stable impedance/admittance transformation and a physical adapted field transformation concept that is also useful for other modelling algorithms. Includes chapters on Eigenmode calculations for various waveguides, concatenations and junctions of arbitrary number of different waveguide sections in complex devices, periodic structures (e.g. Bragg gratings, meander lines, clystron resonators, photonic crystals), antennas (e.g. circular and conformal). Enables the reader to solve partial differential equations in other physical areas by using the described principles. Features an accompanying website with program codes in Matlab© for special problems. Analysis of Electromagnetic Fields and Waves will appeal to electromagnetic field practitioners in primary and applied research as well as postgraduate students in the areas of photonics, micro- and millimetre waves, general electromagnetics, e.g. microwave integrated circuits, antennas, integrated and fibre optics, optoelectronics, nanophotonics, microstructures, artificial materials.

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This book focuses on a fundamental feature of vacuum electronics: the strong interaction of the physics of electron beams and vacuum microwave electronics, including millimeter-wave electronics. The author guides readers from the roots of classical vacuum electronics to the most recent achievements in the field. Special attention is devoted to the physics and theory of relativistic beams and microwave devices, as well as the theory and applications of specific devices.

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Quantitative methods specifically tailored for the marine biologist While there are countless texts published on quantitative methods and many texts that cover quantitative terrestrial ecology, this text fills the need for the special quantitative problems confronting marine biologists and biological oceanographers. The author combines common quantitative techniques with recent advances in quantitative methodology and then demonstrates how these techniques can be used to study marine organisms, their behaviors, and their interactions with the environment. Readers learn how to better design experiments and sampling, employ sophisticated mathematical techniques, and accurately interpret and communicate the results. Most of this text is written at an introductory level, with a few topics that advance to more complex themes. Among the topics covered are plot/plotless sampling, biometrics, experimental design, game theory, optimization, time trends, modeling, and environmental impact assessments. Even readers new to quantitative methods will find the material accessible, with plenty of features to engage their interest, promote learning, and put their knowledge into practice: * One or more examples are provided to illustrate each individual quantitative technique presented in the text * The accompanying CD-ROM features two multimedia programs, several statistical programs, help to run complex statistical programs, and additional information amplifying topics covered in the text * References lead readers to additional information to pursue individual topics in greater depth Quantitative Analysis of Marine Biological Communities, with its extensive use of examples, is ideal for undergraduate and graduate students in marine biology. Marine biologists, regardless of their level of experience, will also discover new approaches to quantitative analysis tailored to the particular needs of their field.

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