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"Brings to life the fight world of that era. Mr. Mitchell's account is full of memorably drawn scenes, and the stories we haven't heard before make Jacobs Beach a cigar-chomping read."— Wall Street Journal Gangsters have always infected fight game. At the end of the First World War, through Prohibition, and into the 1930s, the Mob emerged as a poisonous force, threatening to ravage the sport. But it was only when cutthroat Madison Square Garden promoter Mike Jacobs, chieftain of a notorious patch of Manhattan pavement called Jacobs Beach, stepped aside that the real devil appeared former Murder, Inc. killer and underworld power broker Frankie Carbo, a man known to many simply as Mr. Gray. And Carbo wasn't alone. Along with a crooked cast of characters that included a rich playboy and an urbane lawyer, he controlled boxing through most of the 1950s, with the help of a diabolical deputy, Francis Blinky Palermo, who did much of Mr. Gray s dirty work, reportedly drugging fighters and robbing them blind. Not until 1961, when Attorney General Robert F. Kennedy shipped Carbo and Palermo to jail for twenty-five years, did it all come crashing down. Enriched by the recollections of some of the men who were there, Kevin Mitchell's Jacobs Beach offers a gripping, noirish look at boxing and organized crime in postwar New York City and reveals the fading glamour of both.

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Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

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