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Advanced Statistics with Applications in R fills the gap between several excellent theoretical statistics textbooks and many applied statistics books where teaching reduces to using existing packages. This book looks at what is under the hood. Many statistics issues including the recent crisis with p -value are caused by misunderstanding of statistical concepts due to poor theoretical background of practitioners and applied statisticians. This book is the product of a forty-year experience in teaching of probability and statistics and their applications for solving real-life problems. There are more than 442 examples in the book: basically every probability or statistics concept is illustrated with an example accompanied with an R code. Many examples, such as Who said π? What team is better? The fall of the Roman empire, James Bond chase problem, Black Friday shopping, Free fall equation: Aristotle or Galilei , and many others are intriguing. These examples cover biostatistics, finance, physics and engineering, text and image analysis, epidemiology, spatial statistics, sociology, etc. Advanced Statistics with Applications in R teaches students to use theory for solving real-life problems through computations: there are about 500 R codes and 100 datasets. These data can be freely downloaded from the author's website dartmouth. edu/~eugened. This book is suitable as a text for senior undergraduate students with major in statistics or data science or graduate students. Many researchers who apply statistics on the regular basis find explanation of many fundamental concepts from the theoretical perspective illustrated by concrete real-world applications.

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Praise for the First Edition “This book will serve to greatly complement the growing number of texts dealing with mixed models, and I highly recommend including it in one’s personal library.” —Journal of the American Statistical Association Mixed modeling is a crucial area of statistics, enabling the analysis of clustered and longitudinal data. Mixed Models: Theory and Applications with R, Second Edition fills a gap in existing literature between mathematical and applied statistical books by presenting a powerful examination of mixed model theory and application with special attention given to the implementation in R. The new edition provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as nontraditional applications, such as regrowth curves, shapes, and images. The book features the latest topics in statistics including modeling of complex clustered or longitudinal data, modeling data with multiple sources of variation, modeling biological variety and heterogeneity, Healthy Akaike Information Criterion (HAIC), parameter multidimensionality, and statistics of image processing. Mixed Models: Theory and Applications with R, Second Edition features unique applications of mixed model methodology, as well as: Comprehensive theoretical discussions illustrated by examples and figures Over 300 exercises, end-of-section problems, updated data sets, and R subroutines Problems and extended projects requiring simulations in R intended to reinforce material Summaries of major results and general points of discussion at the end of each chapter Open problems in mixed modeling methodology, which can be used as the basis for research or PhD dissertations Ideal for graduate-level courses in mixed statistical modeling, the book is also an excellent reference for professionals in a range of fields, including cancer research, computer science, and engineering.

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