Genomic and Epigenomic Biomarkers of Toxicology and Disease - Группа авторов

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microRNA biomarkers for liver injury have been proposed (Li et al. 2021). Urinary microRNA biomarkers of drug-induced kidney injury have been suggested (Chorley et al. 2021). Recent studies have provided evidence that tumor-related genes regulated through DNA methylation and microRNA are involved in the occurrence of hepatocellular carcinoma (Lin et al. 2019).

      Circular RNAs

      Circular RNAs (circRNAs) are a class of closed, long, non-coding RNAs with stable expression in various tissues in different mammalian species. These most recently discovered ncRNAs are present abundantly in the transcriptome of eukaryotic cells. They play an important role in the regulation of gene expression (Shao and Jiang 2021) and in tumor development (Jeyaraman et al. 2019). Therefore they are considered potential biomarkers of toxicity and disease (Jeyaraman et al. 2019; Shao and Jiang 2021).

      The rate of publications during the last few years has demonstrated that the developments of genomic and epigenomic biomarkers for predictive toxicity and disease are moving very rapidly, and therefore there is a need for new means to report the updated current status of this new area of research. As editor of Genomic and Epigenomic Biomarkers for Toxicology and Disease: Clinical and Therapeutic Actions, it gives me great pride, pleasure, and honor to introduce this unique book, which encompasses many aspects of genomic and epigenomic biomarker research never brought together in one publication before.

      References

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       Gail M. Nelson and Brian N. Chorley

       Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27709

      Introduction

      MicroRNAs (miRNAs) are short, non-coding RNAs whose primary known function is to regulate the transcription and translation of messenger RNA. Targeting occurs through sequence specificity; however, this interaction is not limited to a single gene. Rather, a particular miRNA can regulate hundreds of genes. In addition, a transcript may be targeted by multiple miRNAs. As a result, it is estimated that between 30% and 80% of all transcribed genes in mammals may be

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