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Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.

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This new edition of Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland features practical guidance on how to handle common inpatient and outpatient challenges seen in pediatric hematology and oncology. Designed as a rapid reference to the latest diagnostic and therapeutic protocols, the text is short and didactic and supplemented with practical algorithms and case studies throughout. Completely revised and updated, there are brand-new chapters on subjects including bone marrow transplantation, pain management and palliative care. Comprehensive, yet concise, the handbook presents essential guidelines on the diagnosis and management of the most common pediatric blood disorders and malignancies, in addition to chemotherapeutic drug information and transfusion protocols. Designed for medical students, residents, and fellows, this user-friendly portable reference is also the perfect companion on the ward for pediatric hematology and oncology nurses.

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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis – β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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LTE- A and Next Generation Wireless Networks: Channel Modeling and Performance describes recent advances in propagation and channel modeling necessary for simulating next generation wireless systems. Due to the radio spectrum scarcity, two fundamental changes are anticipated compared to the current status. Firstly, the strict reservation of a specific band for a unique standard could evolve toward a priority policy allowing the co-existence of secondary users in a band allocated to a primary system. Secondly, a huge increase of the number of cells is expected by combining outdoor base stations with smaller cells such as pico/femto cells and relays. This evolution is accompanied with the emergence of cognitive radio that becomes a reality in terminals together with the development of self-organization capabilities and distributed cooperative behaviors. The book is divided into three parts: Part I addresses the fundamentals (e.g. technologies, channel modeling principles etc.) Part II addresses propagation and modeling discussing topics such as indoor propagation, outdoor propagation, etc. Part III explores system performance and applications (e.g. MIMO Over-the-air testing, electromagnetic safety, etc).

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Thoroughly revised and updated, the second edition of Appreciative Inquiry offers OD and HR professionals a user-friendly resource for discovering how they can tap into the power of the Appreciative Inquiry (AI) process. An innovative process, AI is an effective way to work with a company as an organic system whose success depends on a holistic approach to connect that organization's human, technical, and organizational functions. This new edition meets the challenge of making the AI process accessible and updates three key areas of the process: the theoretical basis, fundamental assumptions and beliefs, and the basic processes. It includes step-by-step guidelines on how to apply AI in a variety of organizational situations and shows how it can be used with a wide range of initiatives, such as coaching, leadership development, strategic planning, and teambuilding. «If there's one book to read on AI, this is it. It provides the context and rationale for this paradigm changing approach to change at any level of system. Buy it, read it, use it and enjoy achieving great results and renewed energy and enthusiasm.» —Barbara Sloan, director, Organizational Development and Learning, New York University, Langone Medical Center «Appreciative Inquiry brings the freedom and creativity of AI together with the 'nuts and bolts' of how to actually do it all. It contains everything I would want to have as a fresh practitioner, from potential designs to sample questions and excellent Case Stories.» —David Shaked, founder and CEO, Almond Insight, United Kingdom «This book serves as a complete roadmap for those interested in the philosophy and practice of Appreciative Inquiry. The Case Stories encourage readers to find their own way on the journey by providing examples of successful interventions.» —Terry Egan, professor, Management Studies, Pepperdine University

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Opens the door to the sustainable production of pharmaceuticals and fine chemicals Driven by both public demand and government regulations, pharmaceutical and fine chemical manufacturers are increasingly seeking to replace stoichiometric reagents used in synthetic transformations with catalytic routes in order to develop greener, safer, and more cost-effective chemical processes. This book supports the discovery, development, and implementation of new catalytic methodologies on a process scale, opening the door to the sustainable production of pharmaceuticals and fine chemicals. Pairing contributions from leading academic and industrial researchers, Sustainable Catalysis focuses on key areas that are particularly important for the fine chemical and pharmaceutical industries, including chemo-, bio-, and organo-catalytic approaches to C–H, C–N, and C–C bond-forming reactions. Chapters include academic overviews of current innovations and industrial case studies at the process scale, providing new insights into green catalytic methodologies from proof-of-concept to their applications in the synthesis of target organic molecules. Sustainable Catalysis provides the foundation needed to develop sustainable green synthetic procedures, with coverage of such emerging topics as: Catalytic reduction of amides avoiding LiAlH4 or B2H6 Synthesis of chiral amines using transaminases Industrial applications of boric acid and boronic acid catalyzed direct amidation reactions C–H activation of heteroaromatics Organocatalysis for asymmetric synthesis Offering a balanced perspective on current limitations, challenges, and solutions, Sustainable Catalysis is recommended for synthetic organic chemists seeking to develop new methodologies and for industrial chemists dedicated to large-scale process development.

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Contains 32 papers from the following seven 2013 Materials Science and Technology (MS&T'13) symposia: Innovative Processing and Synthesis of Ceramics, Glasses and Composites Advances in Ceramic Matrix Composites Advanced Materials for Harsh Environments Advances in Dielectric Materials and Electronic Devices Controlled Synthesis, Processing, and Applications of Structure and Functional Nanomaterials Rustum Roy Memorial Symposium: Processing and Performance of Materials Using Microwaves, Electric and Magnetic Fields, Ultrasound, Lasers, and Mechanical Work Solution Based Processing for Ceramic Materials

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This book features a collection of papers on the issues, intricacies, and challenges relating to energy and environmental science. It offers expert coverage of the various technological aspects of sustainable energy ecosystems, including processes that improve energy efficiency and reduce CO2 and other greenhouse emissions. It also addresses the need for sustainable technologies in extractive metallurgy, materials processing, and manufacturing industries with energy efficient technologies. Some additional contributions examine renewable energy sources such as solar, wind, and biomass.

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Proceedings of symposia sponsored by the Energy Committee of the Extraction and Processing Division and the Light Metals Division of TMS (The Minerals, Metals & Materials Society) Held during the TMS 2012 Annual Meeting & Exhibition Orlando, Florida, USA, March 11-15,2012

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Approaches on carbon dioxide (CO2) emission reduction in metal production by improved energy efficiency in life cycle fuel use, reductions in carbonate-based flux/raw material usage, as well as finding thermodynamically feasible reactions leading to lower emissions. Energy saving techniques for extraction and processing of ferrous and nonferrous metals and other materials Capture, conservation, and use of heat generated from processing

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