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Sets the stage for the design and application of new protein cages Featuring contributions from a team of international experts in the coordination chemistry of biological systems, this book enables readers to understand and take advantage of the fascinating internal molecular environment of protein cages. With the aid of modern organic and polymer techniques, the authors explain step by step how to design and construct a variety of protein cages. Moreover, the authors describe current applications of protein cages, setting the foundation for the development of new applications in biology, nanotechnology, synthetic chemistry, and other disciplines. Based on a thorough review of the literature as well as the authors' own laboratory experience, Coordination Chemistry in Protein Cages Sets forth the principles of coordination reactions in natural protein cages Details the fundamental design of coordination sites of small artificial metalloproteins as the basis for protein cage design Describes the supramolecular design and assembly of protein cages for or by metal coordination Examines the latest applications of protein cages in biology and nanotechnology Describes the principles of coordination chemistry that govern self-assembly of synthetic cage-like molecules Chapters are filled with detailed figures to help readers understand the complex structure, design, and application of protein cages. Extensive references at the end of each chapter serve as a gateway to important original research studies and reviews in the field. With its detailed review of basic principles, design, and applications, Coordination Chemistry in Protein Cages is recommended for investigators working in biological inorganic chemistry, biological organic chemistry, and nanoscience.

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This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).

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Meeting the need for a coherently written and comprehensive compendium combining field theory and particle physics for advanced students and researchers, this book directly links the theory to the experiments. It is clearly divided into two sections covering approaches to field theory and the standard model, and rounded off with numerous useful appendices. A timely volume for high energy and theoretical physicists, as well as astronomers, graduate students and lecturers in physics. Volume 2 concentrates on the main aspects of the Standard Model by addressing its recent developments and future prospects. Furthermore, it gives some thought to intriguing ideas beyond the Standard Model, including the Higgs boson, the neutrino, the concepts of the Grand Unified Theory and supersymmetry, axions, and cosmological developments.

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A reference guide for applications of SEM using Mplus Structural Equation Modeling: Applications Using Mplus is intended as both a teaching resource and a reference guide. Written in non-mathematical terms, this book focuses on the conceptual and practical aspects of Structural Equation Modeling (SEM). Basic concepts and examples of various SEM models are demonstrated along with recently developed advanced methods, such as mixture modeling and model-based power analysis and sample size estimate for SEM. The statistical modeling program, Mplus, is also featured and provides researchers with a flexible tool to analyze their data with an easy-to-use interface and graphical displays of data and analysis results. Key features: Presents a useful reference guide for applications of SEM whilst systematically demonstrating various advanced SEM models, such as multi-group and mixture models using Mplus. Discusses and demonstrates various SEM models using both cross-sectional and longitudinal data with both continuous and categorical outcomes. Provides step-by-step instructions of model specification and estimation, as well as detail interpretation of Mplus results. Explores different methods for sample size estimate and statistical power analysis for SEM. By following the examples provided in this book, readers will be able to build their own SEM models using Mplus. Teachers, graduate students, and researchers in social sciences and health studies will also benefit from this book.

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Catalysis in Electrochemistry: From Fundamental Aspects to Strategies for Fuel Cell Development is a modern, comprehensive reference work on catalysis in electrochemistry, including principles, methods, strategies, and applications. It points out differences between catalysis at gas/surfaces and electrochemical interfaces, along with the future possibilities and impact of electrochemical science on energy problems. This book contributes both to fundamental science; experience in the design, preparation, and characterization of electrocatalytic materials; and the industrial application of electrocatalytic materials for electrochemical reactions. This is an essential resource for scientists globally in academia, industry, and government institutions.

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This practical book summarizes the latest research results of orthogonally polarized lasers, birefringence laser cavities, and their applications. Coverage ranges from basic principles and technologies to the characteristics of different cavities and lasers to various measurement techniques. A number of figures, experimental designs, and measurement curves are included, helping readers gain a thorough understanding of the many applications in modern engineering and start their own projects. Many types of relevant lasers (Helium/Neon lasers, Nd:YAG lasers, laser diodes, etc.) are also discussed.

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Written by two well-known scholars in the field, Combinatorial Reasoning: An Introduction to the Art of Counting presents a clear and comprehensive introduction to the concepts and methodology of beginning combinatorics. Focusing on modern techniques and applications, the book develops a variety of effective approaches to solving counting problems. Balancing abstract ideas with specific topical coverage, the book utilizes real world examples with problems ranging from basic calculations that are designed to develop fundamental concepts to more challenging exercises that allow for a deeper exploration of complex combinatorial situations. Simple cases are treated first before moving on to general and more advanced cases. Additional features of the book include: • Approximately 700 carefully structured problems designed for readers at multiple levels, many with hints and/or short answers • Numerous examples that illustrate problem solving using both combinatorial reasoning and sophisticated algorithmic methods • A novel approach to the study of recurrence sequences, which simplifies many proofs and calculations • Concrete examples and diagrams interspersed throughout to further aid comprehension of abstract concepts • A chapter-by-chapter review to clarify the most crucial concepts covered Combinatorial Reasoning: An Introduction to the Art of Counting is an excellent textbook for upper-undergraduate and beginning graduate-level courses on introductory combinatorics and discrete mathematics.

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The Sponsorship Handbook is a practical guide to sponsorship aimed at practitioners both working for sponsoring companies and those searching for sponsorship. Using the tools, techniques, advice and best practice advocated in this book both sponsors and sponsor seekers will benefit from better servicing and activation once a sponsorship is implemented, with metrics that enable data-based accountability rather than hearsay. «Everyone in the sponsorship industry, from the biggest events and properties to the smallest, are benefitting from the increasing knowledge, data availability, metrics and professionalism in using sponsorship. The Sponsorship Handbook is a part of that process which we hope will bring future success and proven sound results to all in the complex and exciting world of sponsorship.» —Luis Vicente, Head of Partnerships, Manchester City Football Club «An indispensable reference for any marketer who is keen to build his/her brand using sponsorship; the new ascending way to empower brands.» —Faisal Al-Dail, Saudi Post

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This unique book covers fundamentals of organolithium compounds and gives a comprehensive overview of the latest synthetic advances and developments in the field. Part I covers computational and spectroscopic aspects as well as structure-reactivity relationships of organolithiums, whereas Part II deals with new lithium-based synthetic methodologies as well as novel synthetic applications of functionalized lithium compounds. A useful resource for newcomers and active researchers involved in organic synthesis, whether working in academia or industry!

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Written by one of the great teachers of Anatomy, this 50th anniversary edition of Clinical Anatomy continues to provide thousands of medical students, postgraduate trainees and junior doctors across the world with essential anatomical information within a clinical setting. It is particularly appropriate for those preparing for the Membership of the Royal College of Surgeon's Exam. For this new edition, Professor Harold Ellis is joined, for the first time, by a co-author. Professor Vishy Mahadevan is Barber's Company Reader in Anatomy at the Royal College of Surgeons, a renowned teacher of surgical trainees and is also an examiner for the MRCS Exam. Together they provide a detailed, easy-to-follow structured text suitable for anatomy students and trainees of all levels. Fully revised and updated, this new edition features new and re-drawn illustrations, new images of normal anatomy (radiographs, CTs and NMRs) to aid understanding, a revised neuroanatomy section to provide greater clarity and an expansion of the lower limb section. In order to provide revision support, Clinical Anatomy has its own website featuring digital flashcards of all the images found in the textbook available to download for free at www.ellisclinicalanatomy.co.uk

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