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to a well-defined sonographic mass that is predominantly isoechoic to fat with a few anechoic oval lucencies within it. This mass was biopsied and found to be a complex benign cyst.

      Pathology

      • cyst

      Management

      • BI-RADS Assessment Category 4, suspicious; biopsy should be considered

      Pearls and Pitfalls

      Sonography usually is successful in identifying benign cysts. However, occasionally, cysts exhibit internal echoes. These echoes may be caused by poor sonographic technique (e.g., gain settings too high), artifact (e.g., reverberation), proteinaceous debris, hemorrhage, infected debris, or cholesterol crystals. If the material completely moves, then the cyst is probably benign. However, if the material does not move, then an intracystic mass should be considered. In these cases, either aspiration or biopsy should be performed to identify intracystic tumors; 75% of solid intracystic masses are benign (mostly papillomas), 20% malignant, and 5% are phyllodes tumors.

      Suggested Readings

      1. Khaleghian R. Breast cysts: pitfalls in sonographic diagnosis. Australas Radiol 1993;37:192–194.

      2. Sohn C, Blohmer J-U, Hamper UM. Fibrocystic changes and breast cysts. In: Sohn C, Blohmer J-U, Hamper UM, eds. Breast Ultrasound. New York: Thieme; 1999:75–90.

      3. Stavros AT, Dennis MA. The ultrasound of breast pathology. In: Parker SH, Jobe WE, eds. Percutaneous Breast Biopsy. New York: Raven Press; 1993:111–127.

      Case 12

      Case History

      A 32-year-old woman presents with a new left breast lump. She is diabetic and has been insulin dependent since childhood.

      Physical Examination

      • left breast: large hard mass at the 3:00 position

      • right breast: normal exam

      Mammogram

      Mass (Fig. 12–1)

      • margin: circumscribed

      • shape: oval

      • density: high density

Image

       Figure 12–1. In the 3:00 to 4:00 position of the left breast, there is a circumscribed oval mass that corresponds to the palpable mass designated by the metallic marker. (A). Left MLO mammogram. (B). Left CC mammogram.

      Ultrasound

      Low Frequency

      Frequency

      • 8 MHz

      

      Mass

      • margin: ill defined

      • echogenicity: hypoechoic

      • retrotumoral acoustic appearance: severe shadowing, mass completely obscured

      • shape: irregular (Fig. 12–2)

Image

       Figure 12–2. Left radial breast sonogram: Examination of the same mass as Figure 12–3 demonstrates that as the frequency decreases, the mass attenuates the sound less so the internal details of the mass becomes more apparent. The mass has a predominantly hyperechoic periphery with multiple linear lucencies centrally.

      High Frequency

      Frequency

      • 13 MHz

      Associated Findings

      Lower frequency is more informative than high frequency for masses that severely attenuate sound because the internal architecture of the shadowing lesion is better displayed with the lower frequency. (See Fig. 12–3.)

Image

       Figure 12–3. Left radial breast sonogram: With high frequency, the palpable mass attenuates the sound so only a heavily shadowing area is evident.

      

      Pathology

      • diabetic mastopathy

      Management

      • BI-RADS Assessment Category 4, suspicious; biopsy should be considered

      Pearls and Pitfalls

      1. Occasionally diabetes will affect the breast causing diabetic mastopathy. Microscopically, diabetic mastopathy consists of perivasculitis, keloid-like fibrosis, and ductitis and/ or lobulitis. Clinically, this abnormality presents as a hard breast mass. The palpable mass cannot be distinguished from malignancy. However, this presentation in a young woman who has had long-term insulin dependence should be a strong clue to the diagnosis.

      2. The mammographic findings of diabetic mastopathy include a diffusely dense breast, asymmetric focal density, an irregular mass, and less commonly a circumscribed mass.

      3. Sonographically, the fibrosis strongly attenuates sound, so usually only shadowing is evident. With very low frequencies, the internal architecture of the mass is identified.

      Suggested Readings

      1. Boullu S, Andrac L, Piana L, Darmon P, Dutour A, Oliver C. Diabetic mastopathy, complication of type 1 diabetes mellitus: report of two cases and a review of the literature. Diabete Metab 1998;24:448–454.

      2. Byrd BF, Hartmann WH, Graham LS, Hoble HH. Mastopathy in insulin-dependent diabetics. Ann Surg 1987;205:529–532.

      3. Hunfeld KP, Bassler R. Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. Gen Diagn Pathol 1997;143:49–58.

      4. Pluchinotta AM, Talenti E, Lodovichetti G, Tiso E, Biral M. Diabetic fibrous breast disease: a clinical entity that mimics cancer. Eur J Surg Oncol 1995;21:207–209.

      5. Seidman JD, Schnaper LA, Phillips LE. Mastopathy in insulin-requiring diabetes mellitus. Hum Pathol 1994;25:819–824.

      Case 13

      Case History

      A 40-year-old woman presents with a palpable left breast lump.

      Physical Examination

      • left breast: palpable lump in left lateral breast

      • right breast: normal exam

      Mammogram

      Mass (Fig. 13–1)

      • margin: well defined

      • shape: oval

      • density: equal

Image

       Figure 13–1. At the 3:00 position of the left breast, there is an oval mass (arrows). The spot compression view demonstrates that the mass has well-defined margins and a lucent halo around part of the border. (A). Left MLO mammogram. (B). Left CC mammogram. (C). Left MLO spot compression mammogram.

      

      Ultrasound

      Frequency

      • 10 MHz

      Mass

      • margin: well defined

      • echogenicity: hypoechoic

      • retrotumoral acoustic appearance: no shadowing

      • shape: oval (Fig. 13–2)

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