Films from the Future - Andrew Maynard

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like its woolly ancestors.

      Church’s team’s starting point has been the Asian elephant. This is their source of base DNA for their “woolly mammoth 2.0”—their starting source code, if you like. So far, they’ve identified fifty-plus gene sequences they think they can play with to give their modern-day woolly mammoth the traits it would need to thrive in Pleistocene Park, including a coat of hair, smaller ears, and a constitution adapted to cold.

      The next hurdle they face is how to translate the code embedded in their new woolly mammoth genome into a living, breathing animal. The most obvious route would be to impregnate a female Asian elephant with a fertilized egg containing the new code. But Asian elephants are endangered, and no one’s likely to allow such cutting-edge experimentation on the precious few that are still around, so scientists are working on an artificial womb for their reinvented woolly mammoth. They’re making progress with mice and hope to crack the motherless mammoth challenge relatively soon.

      It’s perhaps a stretch to call this creative approach to recreating a species (or “reanimation” as Church refers to it) “de-extinction,” as what is being formed is a new species. Just as the dinosaurs in Jurassic Park weren’t quite the same as their ancestors, Church’s woolly mammoths wouldn’t be the same as their forebears. But they would be designed to function within a specific ecological niche, albeit one that’s the result of human-influenced climate change. And this raises an interesting question around de-extinction: If the genetic tools we are now developing give us the ability to improve on nature, why recreate the past, when we could reimagine the future? Why stick to the DNA code that led to animals being weeded out because they couldn’t survive in a changing environment, when we could make them better, stronger, and more likely to survive and thrive in the modern world?

      This idea doesn’t sit so well with some people, who argue that we should be dialing down human interference in the environment and turning the clock back on human destruction. And they have a point, especially when we consider the genetic diversity we are hemorrhaging away with the current rate of biodiversity loss. Yet we cannot ignore the possibilities that modern genetic engineering is opening up. These include the ability to rapidly and cheaply read genetic sequences and translate them to digital code, to virtually manipulate them and recode them, and then to download them back into the real world. These are heady capabilities, and for some there is an almost irresistible pull toward using them, so much so that some would argue that not to use them would be verging on the irresponsible.

      These tools take us far beyond de-extinction. The reimagining of species like the woolly mammoth is just the tip of the iceberg when it comes to genetic design and engineering. Why stop at recreating old species when you could redesign current ones? Why just redesign existing species when you could create brand-new ones? And why stick to the genetic language of all earth-bound living creatures, when you could invent a new language—a new DNA? In fact, why not go all the way, and create alien life here on earth?

      These are all conversations that scientists are having now, spurred on by breakthroughs in DNA sequencing, analysis, and synthesis. Scientists are already developing artificial forms of DNA that contain more than the four DNA building blocks found in nature.11 And some are working on creating completely novel artificial cells that not only are constructed from off-the-shelf chemicals, but also have a genetic heritage that traces back to computer programs, not evolutionary life. In 2016, for instance, scientist and entrepreneur Craig Venter announced that his team had produced a completely artificial living cell.12 Venter’s cell—tagged “JCVI-syn3.0”—is paving the way for designing and creating completely artificial life forms, and the work being done here by many different groups is signaling a possible transition from biological evolution to biology by design.

      One of the interesting twists to come out of this research is that scientists are developing the ability to “watermark” their creations by embedding genetic identity codes. As research here progresses, future generations may be able to pinpoint precisely who designed the plants and animals around them, and even parts of their own bodies, including when and where they were designed. This does, of course, raise some rather knotty ethical questions around ownership. If you one day have a JCVI-tagged dog, or a JCVI-watermarked replacement kidney, for instance, who owns them?

      This research is pushing us into ethical questions that we’ve never had to face before. But it’s being justified by the tremendous benefits it could bring for current and future generations. These touch on everything from bio-based chemicals production to new medical treatments and ways to stay healthier longer, and even designer organs and body-part replacements at some point. It’s also being driven by our near-insatiable curiosity and our drive to better understand the world we live in and gain mastery over it. And here, just like the scientists in Jurassic Park, we’re deeply caught up in what we can do as we learn to code and recode life.

      But, just because we can now resurrect and redesign species, should we?

      Perhaps one of the most famous lines from Jurassic Park—at least for people obsessed with the dark side of science—is when Ian Malcolm berates Hammond, saying, “Your scientists were so preoccupied with whether they could, they didn’t stop to think if they should.”

      Ethics and responsibility in science are complicated. I’ve met remarkably few scientists and engineers who would consider themselves to be unethical or irresponsible. That said, I know plenty of scientists who are so engaged with their work and the amazing things they believe it’ll lead to that they sometimes struggle to appreciate the broader context within which they operate.

      The challenges surrounding ethical and responsible research are deeply pertinent to de-extinction. A couple of decades ago, they were largely academic. The imaginations of scientists, back when Jurassic Park hit the screen, far outstripped the techniques they had access to at the time. Things are very different now, though, as research on woolly mammoths and other extinct species is showing. In a very real way, we’re entering a world that very much echoes the “can-do” culture of Hammond’s Jurassic Park, where scientists are increasingly able to do what was once unimaginable. In such a world, where do the lines between “could” and “should” lie, and how do scientists, engineers, and others develop the understanding and ability to do what is socially responsible, while avoiding what is not?

      Of course, this is not a new question. The tensions between technological advances and social impacts were glaringly apparent through the Industrial Revolution, as mechanization led to job losses and hardship for some. And the invention of the atomic bomb, followed by its use on Nagasaki and Hiroshima in the second World War, took us into deeply uncharted territory when it came to balancing what we can and should do with powerful technologies. Yet, in some ways, the challenges we’ve faced in the past over the responsible development and use of science and technology were just a rehearsal for what’s coming down the pike, as we enter a new age of technological innovation.

      For all its scientific inaccuracies and fantastical scenarios, Jurassic Park does a good job of illuminating the challenges of unintended consequences arising from somewhat naïve and myopic science. Take InGen’s scientists, for instance. They’re portrayed as being so enamored with what they’ve achieved that they lack the ability to see beyond their own brilliance to what they might have missed.13 Of course, they’re not fools. They know that they’re breaking new ground by bringing dinosaurs back to life, and that there are going to be risks. It would be problematic, for instance, if any of the dinosaurs escaped the island and survived, and they recognize this. So the scientists design them to be dependent on a substance it was thought they couldn’t get enough of naturally, the essential amino acid lysine. This was the so-called “lysine contingency,” and, as it turns out, it isn’t too dissimilar from techniques real-world genetic engineers use to control their progeny.

      Even though it’s essential to life, lysine isn’t synthesized naturally by animals. As a result, it has to be ingested, either in its raw form or by eating foods that contain it, including plants or bacteria (and their products) that produce it naturally, for instance, or other animals. In their wisdom, InGen’s scientists assume that they can engineer lysine dependency into their dinosaurs, then keep them alive with a diet rich in the substance,

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