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Filarial parasites affect over 130 million people in tropical and subtropical regions of the world, causing prolonged and debilitating illnesses ranging from lymphatic inflammation and elephantiasis to skin disease and blindness. This wide-ranging book, the outcome of an international symposium, focuses on the host-parasite interaction in lymphatic filariasis and onchocerciasis. Papers examine all aspects of the pathological and immunological consequences of infection as well as diagnosis, treatment, and control of filarial disease.

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A multidisciplinary volume presenting recent research relating to papillomaviruses and their association with certain types of malignant lesions. Presents up-to-date findings on their classification and their molecular biology and cell-virus interactions, including mode of entry, modification of genetic material and pathogenecity; their relationship to various kinds of skin conditions; their association with cervical carcinoma and carcinomas of the bladder and alimenatry tract, with descriptions of in vitro studies; and finally, their immunology and possible therapeutic agents, e.g., interferon and vaccination. The only comprehensive text on the subject, it brings together the work of many of the most prominent researchers in the field.

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Epithelial cells cover the outer and inner surfaces of the body, forming a selective polarized barrier between the intercellualar space and the 'external' world. Linking the cells of this continuous layer and contributing to epithelial organization and function are specialized membrane domains–desmosomes, gap junctions, and occluding junctions. The contributors to this multidisciplinary symposium volume explore the nature of such junctional structures, focusing on the molecular organization and diversity of their constituent proteins, their formation and control, and interactions with ions and cytoskeletal elements. The physiological significance of cell-cell interaction in epithelia is considered, with reference to cell adhesion, barrier formation and intercellular communication, and to the functional implications for tissue architecture, embryonic development, morphogenesis and carcinogenesis.

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Ciba Foundation Symposium 123 Antidepressants and Receptor Function Chairman: Dennis Murphy, 1986 Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys. This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.

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