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      Generally, when producing chemicals from whole lignocelluloses, the yields of conversion processes are lower compared to the same synthesis starting from the sugar (e.g. fructose, xylose, and glucose); hence, process costs tend to increase. Predominantly, the differences of lignin content and feedstock density depending on the considered biomass (e.g. grasses vs. softwood vs. hardwood) cause variation on the process yields as well as the amount of volumes to be processed (e.g. grasses require bigger volumes). In particular, the hydrogen bonding between the different components (i.e. lignin, hemicellulose, and cellulose) reduces the available surface to processing, increasing the structural complexity and the recalcitrant nature of lignocellulosic feedstocks. Furthermore, the inorganic metals (e.g. Mg and Ca) naturally present in plants may induce reactor fouling by induced precipitation of salts or heterogeneous catalyst (e.g. zeolites) deactivation by ion exchange [54,55]. Above all, the aforementioned large presence of heteroatoms (particularly oxygen) increases the moieties' reactivity, leading to low atom efficiency and occurrence of undesired side reactions, such as the synthesis of humins that act as a catalyst deactivator (in a similar way to coke) and promote reactor fouling.

      In order to overcome these challenges, strategies include the use of unconventional solvents, milder conditions, and various pretreatment methods in order to separate the single components (e.g. decompose cellulose to glucose) and allow targeted valorization.

      Other conventional solvents have certainly been employed in biomass applications as well, but focus has been placed on coupling biomass processes with bio‐based or green solvents. These include bio‐based conventional solvents, terpenes, ionic liquids, switchable solvents, fatty acid/glycerol‐based solvents, and liquid carbon dioxide.

      Conventional bio‐based solvents can mostly be used as a drop‐in replacement. Common examples of this are glycerol, ethyl lactate, and 2‐methyltetrahydrofuran. In addition, acetone and various linear alcohols (e.g. methanol, ethanol, and butanol) can be derived from bio‐based sources, but current technology is not the most efficient [65]. The use of these solvents may offer an advantage, given the chemical affinity to the desired platform biomolecules. These solvents alone, however, have also induced the formation of humins.

      Terpenes can be extracted from various materials in nature and subsequently used as a bio‐based solvent. Cis‐rich pinane can be extracted from pine tree by‐products and used as a suitable replacement for n‐hexane [66]. Another example, D‐limonene, has similar properties and comes from orange peels. It has been safely designated by the USFDA for use in home and personal products [65]. However, the small volumes of these potential solvents limit their use to specialty applications (e.g. cosmetics).

      Ionic liquids (ILs) are also being explored as solvents for biomass processes. Recently, they have been a major focus in biomass applications for their potential to overcome other solvent limitations because of their versatility (i.e. large working temperature range, acidic or basic capabilities, and compatibility with different materials) and non‐volatility. Initial studies show that ionic liquids can offer satisfactory product yields when combined with metal halides. In fact, whereas the ionic liquid provides a stable medium for sugar conversion, the halide acts as Brønsted acid catalyzing the system. Another advantage of using ionic liquids is that they are generally considered

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