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       A Framework for Scientific Discovery through Video Games

       ACM Books

      Editor in Chief

      M. Tamer Özsu, University of Waterloo

      ACM Books is a new series of high-quality books for the computer science community, published by ACM in collaboration with Morgan & Claypool Publishers. ACM Books publications are widely distributed in both print and digital formats through booksellers and to libraries (and library consortia) and individual ACM members via the ACM Digital Library platform.

      This book by Seth Cooper is a revised version of the dissertation that won the 2011 ACM Doctoral Dissertation Award. Other books in the series include those listed below.

      A Framework for Scientific Discovery through Video Games

      Seth Cooper, University of Washington

      2014

      Trust Extension as a Mechanism for Secure Code Execution on Commodity Computers

      Bryan Jeffrey Parno, Microsoft Research

      2014

      Embracing Interference in Wireless Systems

      Shyamnath Gollakota, University of Washington

      2014

       A Framework for Scientific Discovery through Video Games

       Seth Cooper

      University of Washington

       ACM Books #3

      Copyright © 2014 by the Association for Computing Machinery and Morgan & Claypool Publishers

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means—electronic, mechanical, photocopy, recording, or any other except for brief quotations in printed reviews—without the prior permission of the publisher.

      Designations used by companies to distinguish their products are often claimed as trademarks or registered trademarks. In all instances in which Morgan & Claypool is aware of a claim, the product names appear in initial capital or all capital letters. Readers, however, should contact the appropriate companies for more complete information regarding trademarks and registration.

       A Framework for Scientific Discovery through Video Games

      Seth Cooper

       books.acm.org

       www.morganclaypool.com

      ISBN: 978-1-62705-504-8 print

      ISBN: 978-1-62705-505-5 ebook

      ISBN: 978-1-62705-506-2 ePub

      Series ISSN: (to come)

      DOIs: 10.1145/2625848 Book

      10.1145/2625848.2625849 Preface

      10.1145/2625848.2625850 Chapter 1

      10.1145/2625848.2625851 Chapter 2

      10.1145/2625848.2625852 Chapter 3

      10.1145/2625848.2625853 Chapter 4

      10.1145/2625848.2625854 Chapter 5

      10.1145/2625848.2625855 Chapter 6

      10.1145/2625848.2625856 Chapter 7

      10.1145/2625848.2625857 Bibliography

      A publication in the ACM Books series, #3

      Editor in Chief: M. Tamer Özsu, University of Waterloo

      First Edition

      10 9 8 7 6 5 4 3 2 1

       To my parents, Harris and Beth Cooper

       Contents

       Preface

       Chapter 1Introduction

       1.1 Motivation

       1.2 Problem Statement

       1.2.1 Game Design Problem

       1.2.2 Biochemistry Discovery Problem

       1.3 Outline

       Chapter 2Related Literature

       2.1 Volunteer Computing and Human Computation

       2.2 Serious Games and Gamification

       2.3 Computational Biochemistry

       Chapter 3 Framework

       3.1 Introduction

       3.2 Biochemistry Background

       3.3 Framework Description

       3.3.1 Architecture

       3.3.2 Coevolution Strategy

       3.3.3 Categorization as a game

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