Sustainable Nanotechnology - Группа авторов

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group can increase their affinity toward a given compound with improved efficiency. NMs can also give us an opportunity to enhance them with improved optical, magnetic, and catalytic properties [7]. For instance, in the case of semiconductor quantum dots, the variation in fluorescence emission capacity depends strongly on the difference in particle size. Nanoscale materials have different physicochemical and biological properties, which meet many growing needs of society. By exploring the novel development of NMs with new properties, it can be possible to enhance the performance of materials significantly, in terms of achievement of more product performance using less material [8, 9]. Development of NMs using required approach having ecofriendly characteristics is need of todays industries like textiles, paints and biomedical [10]. The available methods used for preparation of nanostructured materials are ultrasonication, reverse‐phase micelle, microwave assisted techniques, and deposition of vapour by chemical and physical means [11]. Nano metal oxides such as Al2O3, TiO2, and SiO2 have been efficiently obtained from the nature and is one of the best examples of such techniques [12]. Today, the available solar cells having effectiveness of 10–25% are made up of silicon [13]. The cost of a solar cell can be reduced by improving its efficiency, which makes it more economically competitive [14]. By using nanostructured surface for reflectivity in solar cell devices, the antireflection ability may be enhanced effectively using NMs having diameter less than the wavelength of incident light. To increase the usage of solar light, antireflection NMs are patterned with active components, and thus the cost can be reduced [15]. Also, light‐capturing capacity can be additionally increased by light trapping, so it requires less amount of material to absorb solar light, and the cost can be reduced [16].

      NMs can be used to solve various challenges in the environment, e.g. it can be used to restore the polluted soil with cleaning of water and air, and it also can reduce the impact of chemical manufacturing using nanoscale catalyst [17, 18]. Therefore, various opportunities are offered by nanotechnology in manufacturing novel NMs that improves living conditions using advanced techniques in various fields.

      Despite significant development and increased utilization in many marketed products, NMs and their technology are still facing challenges in energy, environment, health, and safety (EHS). One of the principal challenges that comes up with nanotechnology is its influence on environment and its toxicity to humans. The cause for toxicity in humans is due to the availability of NMs with different properties that might lead to adverse drug reaction. NMs undertake biodegradation in their working atmosphere. This might lead to intracellular changes and gene modifications. If the gene alteration is undesirable, then it might prove hazardous for human beings. NMs are not always environmentally safe. They sometimes enter the ecology's food chain and cause changes. So, it is necessary first to understand the life cycle of NMs with their activity in the environment. It is necessary to focus on the size, structure, and reactivity of NMs in environmental systems [19].

      1 address the accountability of NMs and their related toxicity.

      2 strengthen large‐scale manufacturing of NMs and minimize possible risks involved in it.

      3 develop new capabilities for sustainable environment and health.

      4 have a robust regulatory guideline and support.

      2.2.1 Accountability of Nanomaterials and Related Toxicity

      2.2.1.1 Size

      The characteristic that brings the unique performance of NMs is its nanoscale structured engineering. At the same time, this physicochemical property creates opportunity for increased interaction with biological tissues at molecular level having similar size and structure. This same principle has caused pharmaceutical companies to formulate highly efficient and intelligent drug delivery systems for several diseases, which was not possible in their conventional size formulation. Not only in health care but also in all other sectors, these NMs have improved their characteristics such as strength, weight, appearance, efficiency, and durability. A research for pharmacological action based on NP size shows that NPs < 50 nm diffuse quickly to tissues of living things and bring potential toxicity to those tissues, while NPs >50 nm taken up by a cleaning system of mammalians, reticuloendothelial system (RES), and the RES organs, viz., liver, spleen, and lymph nodes, will become the target of oxidative stress [23]. Few other researchers show that particles <10 nm get deposited in the tracheobronchial of the lung, while all the other <100 nm particles are deposited all over the lungs and cause respiratory adverse effects [24–26]. Several other toxic effects, such as mitochondrial perturbation by silica [27], damage to nervous system [28], endothelial dysfunction [29], generation of neoantigens [30], and immune toxicity [31], are reported with limited clinical evidence. The uptake and interaction in biological tissues observed previously and substances generally regarded as safe now show adverse responses. The NPs generated during manufacturing may get inhaled, and ultrafine particles (<100 nm) induce pulmonary inflammation, oxidative stress, and distal organ involvement or get absorbed through the lungs and can create toxicity in vital systemic circulation. As the size reduces, it increases surface area and finally enhances capability to react with oxygen. Due to increased reaction with oxygen, it enhances inflammation, fibrosis, cytotoxicity, oxidative injury, and carbon deposition in lungs [32]. It is the sole responsibility of the researcher to involve toxicology scientists and closely monitor the toxicity of NPs during each development stage until robust regulatory guidelines based on size and surface area become available. One also needs to take care until the airborne NP hazard has been appropriately assessed; this risk should be managed by taking steps to avoid large quantities of these NPs becoming airborne.

      2.2.1.2 Surface Area

      The surface area increases with the reduction in the size of the same quantity of any material. NPs, although made from nontoxic materials, become hazardous, as the material developed reactivity at molecular level. The toxic effect of few such particles does not seem hazardous, but if more surface area becomes available, it will further add on risk. Thus, surface area also requires attention and monitoring for the toxicity study along with the size. As size reduces, it increases surface area and finally enhances capability to react with oxygen. Due to increased reaction with oxygen, it increases inflammation, fibrosis, cytotoxicity, oxidative injury, and carbon deposition in lungs of mineral particles, quartz, titanium dioxide, asbestos, and carbon black despite

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