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Biochemistry For Dummies. John T. Moore
Читать онлайн.Название Biochemistry For Dummies
Год выпуска 0
isbn 9781119860976
Автор произведения John T. Moore
Жанр Химия
Издательство John Wiley & Sons Limited
FIGURE 3-7: Cis and trans isomers.
If the two groups attached to either of the carbon atoms of the double bond are the same, cis-trans isomers aren’t possible. Cis isomers are the normal form of fatty acids, whereas food processing tends to convert some of the cis isomers to the trans isomers. The trans isomers are less biologically friendly (as in trans fats, which tend to be carcinogenic) than the cis isomers.
Cis-trans isomers are also possible in cyclic systems. The cis form has similar groups on the same side of the ring, whereas the trans form has similar groups above and below the ring.
Chiral carbons
Trying to put your gloves on the wrong hands is kind of like another property of biological systems: handedness. Left-handed molecules rotate plane-polarized light to the left, and right-handed molecules rotate plane-polarized light to the right.
Identifying chiral molecules
The presence of an asymmetric, or chiral, carbon atom is sufficient to produce a handed molecule.
FIGURE 3-8: The structure of glucose, a sugar with four chiral carbon atoms.
Determining the chiral form: Enantiomer or stereoisomer?
All substances have a mirror image (okay, except vampires); however, if a chiral carbon atom is present, the mirror images are nonsuperimposable. Hold out your left and right hands, palms up — they are nonsuperimposable mirror images. These two mirror images are called enantiomers. The different chiral forms differ from each other in two aspects:
How they affect light
How they interact with other chiral substances (usually only one chiral form is biologically active)
To determine how a particular form affects light, it’s necessary to use plane-polarized light, in which all the light waves vibrate in the same plane. When you use this kind of light, a chiral substance rotates the vibrational plane of the light — one form (the dextrorotatory, d,
Illustrating the chiral compound: Fischer projection formulas
The chemist Emil Fischer developed a method of drawing a compound to illustrate which stereoisomer was present. These Fischer projection formulas are very useful in biochemistry. In a projection formula, a chiral carbon is placed in the center of a + pattern. The vertical lines (bonds) point away from the viewer, and the horizontal lines point toward the viewer (see Figure 3-9). Fischer used the D designation if the most important group (the group whose central atom had the highest atomic number) was to the right of the carbon, and the L designation if the most important group (again, the group whose central atom has the highest atomic number) was to the left of the carbon. Figure 3-10 shows two Fischer projection formulas.
FIGURE 3-9: The construction of a Fischer projection.
FIGURE 3-10: Fischer projection formulas distinguish stereoisomers.
Wow, that’s all the important organic chemistry you need for biochemistry in about 16 pages. How many pages did your organic chemistry text have, and what did it cost? This book is a real bargain!
Part 2
The Meat of Biochemistry: Proteins
IN THIS PART …
Building proteins with amino acids
Putting the pieces together with amino acid sequencing and protein structures
Playing stop-and-go with enzyme kinetics, using catalysts and inhibitors
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