LITMIR.BIZ

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible

Подробнее

Programming multi-core and many-core computing systems Sabri Pllana, Linnaeus University, Sweden Fatos Xhafa, Technical University of Catalonia, Spain Provides state-of-the-art methods for programming multi-core and many-core systems The book comprises a selection of twenty two chapters covering: fundamental techniques and algorithms; programming approaches; methodologies and frameworks; scheduling and management; testing and evaluation methodologies; and case studies for programming multi-core and many-core systems. Program development for multi-core processors, especially for heterogeneous multi-core processors, is significantly more complex than for single-core processors. However, programmers have been traditionally trained for the development of sequential programs, and only a small percentage of them have experience with parallel programming. In the past, only a relatively small group of programmers interested in High Performance Computing (HPC) was concerned with the parallel programming issues, but the situation has changed dramatically with the appearance of multi-core processors on commonly used computing systems. It is expected that with the pervasiveness of multi-core processors, parallel programming will become mainstream. The pervasiveness of multi-core processors affects a large spectrum of systems, from embedded and general-purpose, to high-end computing systems. This book assists programmers in mastering the efficient programming of multi-core systems, which is of paramount importance for the software-intensive industry towards a more effective product-development cycle. Key features: Lessons, challenges, and roadmaps ahead. Contains real world examples and case studies. Helps programmers in mastering the efficient programming of multi-core and many-core systems. The book serves as a reference for a larger audience of practitioners, young researchers and graduate level students. A basic level of programming knowledge is required to use this book.

Подробнее

This first book on nanocellulose and nanohydrogels for biomedical applications is unique in discussing recent advancements in the field, resulting in a comprehensive, well-structured overview of nanocellulose and nanohydrogel materials based nanocomposites. The book covers different types of nanocellulose materials and their recent developments in the drug delivery and nanomedicine sector, along with synthesis, characterization, as well as applications in the biotechnological and biomedical fields. The book also covers the current status and future perspectives of bacterial cellulose and polyester hydrogel matrices, their preparation, characterization, and tissue engineering applications of water soluble hydrogel matrices obtained from biodegradable sources. In addition, the chitosan-based hydrogel and nanogel matrices, their involvement in the current biofabrication technologies, and influencing factors towards the biomedical sector of biosensors, biopharmaceuticals, tissue engineering appliances, implant materials, diagnostic probes and surgical aids are very well documented. Further, the history of cellulose-based and conducting polymer-based nanohydrogels, their classification, synthesis methods and applicability to different sectors, the challenges associated with their use, recent advances on the inhibitors of apoptosis proteins are also included. The recent developments and applications in the drug delivery sector gives an overview of facts about the nanofibrillated cellulose and copoly(amino acid) hydrogel matrices in the biotechnology and biomedicine field. This book serves as an essential reference for researchers and academics in chemistry, pharmacy, microbiology, materials science and biomedical engineering.

Подробнее

This book presents programming by demonstration for robot learning from observations with a focus on the trajectory level of task abstraction Discusses methods for optimization of task reproduction, such as reformulation of task planning as a constrained optimization problem Focuses on regression approaches, such as Gaussian mixture regression, spline regression, and locally weighted regression Concentrates on the use of vision sensors for capturing motions and actions during task demonstration by a human task expert

Подробнее

This book explores the impact of information systems on the management of North–South asymmetric strategic alliances through a series of in-depth case studies which analyze different types of partnerships. Positioned at the heart of the value creation process, the choice of information system seems to be becoming a strategic issue which should be centered not only on the organizational decisions related to the type of alliance but also the management systems of each of the partners. The authors provide an understanding of the nature of this relationship between the organizational structure and the method of information system integration in asymmetric alliances. The in-depth analysis of strategic alliance case-studies illustrates the different methods of information system integration, which are themselves linked to the organisational and structural choices of the alliance. These methods are characterized by information-sharing and coordination mechanisms as well as the balance of control over shared activities developed by the distinct partners.

Подробнее

The phenomenon of adhesion is of cardinal importance in the pharmaceutical, biomedical and dental fields. A few eclectic examples will suffice to underscore the importance/relevance of adhesion in these three areas. For example, the adhesion between powdered solids is of crucial importance in tablet manufacture. The interaction between biodevices (e.g., stents, bio-implants) and body environment dictates the performance of such devices, and there is burgeoning research activity in modifying the surfaces of such implements to render them compatible with bodily components. In the field of dentistry, the modern trend is to shift from retaining of restorative materials by mechanical interlocking to adhesive bonding. This unique book addresses all these three areas in an easily accessible single source. The book contains 15 chapters written by leading experts and is divided into four parts: General Topics; Adhesion in Pharmaceutical Field; Adhesion in Biomedical Field; and Adhesion in Dental Field. The topics covered include: – Theories or mechanisms of adhesion. – Wettability of powders. – Role of surface free energy in tablet strength and powder flow behavior. – Mucoadhesive polymers for drug delivery systems. – Transdermal patches. – Skin adhesion in long-wear cosmetics. – Factors affecting microbial adhesion. – Biofouling and ways to mitigate it. – Adhesion of coatings on surgical tools and bio-implants. – Adhesion in fabrication of microarrays in clinical diagnostics. – Antibacterial polymers for dental adhesives and composites. – Evolution of dental adhesives. – Testing of dental adhesives joints.

Подробнее

The second edition of the «go-to» reference in this field is completely updated and features more than 80% new content, with emphasis on new developments in the field, especially in industrial applications. No other book covers the topic in such a comprehensive manner and in such high quality. Edited by the Nobel laureate R. H. Grubbs and E. Khosravi, Volume 3 of the 3-volume work focusses on polymer synthesis. With a list of contributors that reads like a «Who's-Who» of metathesis, this is an indispensable one-stop reference for chemists in academia and industry. View the set here – http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527334246.html Other available volumes: Volume 1: Catalyst Development and Mechanism, Editors: R. H. Grubbs and A. G. Wenzel – http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html Volume 2: Applications in Organic Synthesis, Editors: R. H. Grubbs and D. J. O´Leary – http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339493.html

Подробнее

Practices associated with the culture of “scholarly” reading have been developed over many centuries and annotations themselves have become the subject of study, either as additional elements in connection with the original texts or as documents in their own right. The first “scholarly” reading techniques, seen historically from the 12th Century onwards, combine reading and writing in a process known as lettrure, involving both attentive reading and commentary. The Internet has transformed this activity, adding technical layers that relate both to the reading and writing process as well as to the circulation of texts; their potential and effective augmentation, diffusion, and reception. This book examines digitized reading and writing by focusing primarily on the conditions for the co-construction of scientific knowledge and its augmentation. The authors present numerous examples of studies and personal feedback concerning the intellectual process, open critical spaces, collaborative scholarly publishing, methods for the circulation and mediatization of knowledge, as well as the techniques and tools employed.

Подробнее

Features of statistical and operational research methods and tools being used to improve the healthcare industry With a focus on cutting-edge approaches to the quickly growing field of healthcare, Healthcare Analytics: From Data to Knowledge to Healthcare Improvement provides an integrated and comprehensive treatment on recent research advancements in data-driven healthcare analytics in an effort to provide more personalized and smarter healthcare services. Emphasizing data and healthcare analytics from an operational management and statistical perspective, the book details how analytical methods and tools can be utilized to enhance healthcare quality and operational efficiency. Organized into two main sections, Part I features biomedical and health informatics and specifically addresses the analytics of genomic and proteomic data; physiological signals from patient-monitoring systems; data uncertainty in clinical laboratory tests; predictive modeling; disease modeling for sepsis; and the design of cyber infrastructures for early prediction of epidemic events. Part II focuses on healthcare delivery systems, including system advances for transforming clinic workflow and patient care; macro analysis of patient flow distribution; intensive care units; primary care; demand and resource allocation; mathematical models for predicting patient readmission and postoperative outcome; physician–patient interactions; insurance claims; and the role of social media in healthcare. Healthcare Analytics: From Data to Knowledge to Healthcare Improvement also features: • Contributions from well-known international experts who shed light on new approaches in this growing area • Discussions on contemporary methods and techniques to address the handling of rich and large-scale healthcare data as well as the overall optimization of healthcare system operations • Numerous real-world examples and case studies that emphasize the vast potential of statistical and operational research tools and techniques to address the big data environment within the healthcare industry • Plentiful applications that showcase analytical methods and tools tailored for successful healthcare systems modeling and improvement The book is an ideal reference for academics and practitioners in operations research, management science, applied mathematics, statistics, business, industrial and systems engineering, healthcare systems, and economics. Healthcare Analytics: From Data to Knowledge to Healthcare Improvement is also appropriate for graduate-level courses typically offered within operations research, industrial engineering, business, and public health departments. HUI YANG, PhD, is Associate Professor in the Harold and Inge Marcus Department of Industrial and Manufacturing Engineering at The Pennsylvania State University. His research interests include sensor-based modeling and analysis of complex systems for process monitoring/control; system diagnostics/ prognostics; quality improvement; and performance optimization with special focus on nonlinear stochastic dynamics and the resulting chaotic, recurrence, self-organizing behaviors. EVA K. LEE, PhD, is Professor in the H. Milton Stewart School of Industrial and Systems Engineering at the Georgia Institute of Technology, Director of the Center for Operations Research in Medicine and HealthCare, and Distinguished Scholar in Health System, Health Systems Institute at both Emory University School of Medicine and Georgia Institute of Technology. Her research interests include health-risk prediction; early disease prediction and diagnosis; optimal treatment strategies and drug delivery; healthcare outcome analysis and treatment prediction; public health and medical preparedness; large-scale healthcare/medical decision analysis and quality improvement; clinical translational

Подробнее

Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions – including key routes for synthesizing complex molecules. • Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic syntheses • Compiles novel and efficient synthetic multicomponent procedures to give readers a complete picture of this class of organic reactions • Helps readers to design efficient and practical transformations using multicomponent reaction strategies • Describes reaction background, applications to synthesize complex molecules and drugs, and reaction mechanisms

Подробнее