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CMV infections in long-term renal transplant recipients are associated with the loss of FcRγ from LIR-1+ NK cells. Eur J Immunol 2016;46:2597–2608.

119Della Chiesa M, Falco M, Bertaina A, Muccio L, Alicata C, Frassoni F, Locatelli F, Moretta L, Moretta A: Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C–/– umbilical cord blood. J Immunol 2014;192:1471–1479.

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122Jost S, Tomezsko PJ, Rands K, Toth I, Lichterfeld M, Gandhi RT, Altfeld M: CD4+ T-cell help enhances NK cell function following therapeutic HIV-1 vaccination. J Virol 2014;88:8349–8354.

123Krishnaraj R, Bhooma T: Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion. Immunol Lett 1996;50:59–63.

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126Myśliwska J, Bryl E, Trzonkowski P, Myśliwski A: Compensatory effect of TNFalpha on low natural killer activity in the elderly. Acta Biochim Pol 2000;47:301–311.

127Santos MS, Meydani SN, Leka L, Wu D, Fotouhi N, Meydani M, Hennekens CH, Gaziano JM: Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. Am J Clin Nutr 1996;64:772–777.

128Pearce EL, Pearce EJ: Metabolic pathways in immune cell activation and quiescence. Immunity 2013;38:633–643.

129Rostamzadeh D, Yousefi M, Haghshenas MR, Ahmadi M, Dolati S, Babaloo Z: mTOR Signaling pathway as a master regulator of memory CD8+ T-cells, Th17, and NK cells development and their functional properties. J Cell Physiol 2019;234:12353–12368.

130Marçais A, Marotel M, Degouve S, Koenig A, Fauteux-Daniel S, Drouillard A, Schlums H, Viel S, Besson L, Allatif O, Bléry M, Vivier E, Bryceson Y, Thaunat O, Walzer T: High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors. Elife 2017;6:pii:e26423.

131Donnelly RP, Loftus RM, Keating SE, Liou KT, Biron CA, Gardiner CM, Finlay DK: mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J Immunol 2014;193:4477–4484.

132Keppel MP, Saucier N, Mah AY, Vogel TP, Cooper MA: Activation-specific metabolic requirements for NK Cell IFN-γ production. J Immunol 2015;194:1954–1962.

133Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM: Metabolic reprogramming supports IFN-γ production by CD56bright NK cells. J Immunol 2016;196:2552–2560.

134Miranda D, Jara C, Ibañez J, Ahumada V, Acuña-Castillo C, Martin A, Córdova A, Montoya M: PGC-1α-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells. Mediators Inflamm 2016;2016:9605253.

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136Nabekura T, Lanier LL: Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection. J Exp Med 2016;213:2745–2758.

137Nielsen CM, White MJ, Bottomley C, Lusa C, Rodríguez-Galán A, Turner SE, Goodier MR, Riley EM: Impaired NK cell responses to pertussis and H1N1 influenza vaccine antigens in human cytomegalovirus-infected individuals. J Immunol 2015;194:4657–4667.

138Cooper MA, Elliott JM, Keyel PA, Yang L, Carrero JA, Yokoyama WM: Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci USA 2009;106:1915–1919.

139Leong JW, Chase JM, Romee R, Schneider SE, Sullivan RP, Cooper MA, Fehniger TA: Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. Biol Blood Marrow Transplant 2014;20:463–473.

140Bastola R, Noh G, Keum T, Bashyal S, Seo JE, Choi J, Oh Y, Cho Y, Lee S: Vaccine adjuvants: smart components to boost the immune system. Arch Pharm Res 2017;40:1238–1248.

141Manser AR, Uhrberg M: Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance. Cancer Immunol Immunother 2016;65:417–426.

142Bengnér M, Béziat V, Ernerudh J, Nilsson BO, Löfgren S, Wikby A, Malmberg KJ, Strindhall J: Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity. Age (Dordr) 2014;36:571–582.

143Andrew MK, Bowles SK, Pawelec G, Haynes L, Kuchel GA, McNeil SA, McElhaney JE: Influenza vaccination in older adults: recent innovations and practical applications. Drugs Aging 2019;36:29–37.

144Lal H, Cunningham AL, Heineman TC: Adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med 2015;373:1576–1577.

145Doherty TM, Del Giudice G, Maggi S: Adult vaccination as part of a healthy lifestyle: moving from medical intervention to health promotion. Ann Med 2019;51:128–140.

146McElhaney

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