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a strategy of watchful waiting in carefully selected patients may be reasonable. Additional data from ongoing trials will hopefully further inform best clinical practice and provide direction to both reduce unnecessary practice variation and improve patient outcomes.

      Acknowledgments

      Dr. Sean M. Bagshaw is supported by a Canada Research Chair in Critical Care Nephrology.

      Disclosure Statement

      S.M.B. and R.W. have served as paid consultants to and received speaker fees from Baxter. They have also received unrestricted grant support from Baxter, in partnership with the Canadian Institutes of Health Research, to fund a multinational multicenter RCT to evaluate the timing of RRT in AKI (STARRT-AKI). The authors declare no further conflicts of interest.

      References

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22Bagshaw SM, Wald R: Strategies for the optimal timing to start renal replacement therapy in critically ill patients with acute kidney injury. Kidney Int 2017;91:1022–1032.

      23Bouman

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