Secondary Metabolites of Medicinal Plants - Bharat Singh

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      2.19.1 Ethnopharmacological Properties and Phytochemistry

      Cannabis sativa L. (Fam. – Cannabaceae) is an annual herbaceous plant and indigenous to Central Asia and India subcontinent. The phytochemicals in this plant species are secreted by the glandular trichomes found on the calyx and bracts of flowers. The Cannabis plant is used in the treatment of nausea and vomiting during chemotherapy; it also recommended to treat chronic pain and muscle spasms and central nervous system (CNS) and as anti-inflammatory (Li 1973; Gubellini et al. 2002; Brotchie 2003; Johnson et al. 2009; Radwan et al. 2009; Styrczewska et al. 2012; Tabrez et al. 2012; Borgelt et al. 2013; Whiting et al. 2015), as well as Parkinson's disease (Pisani et al. 2005, 2010, 2011). Based on the 2500-year-old ancient reports unearthed in the Turpan district in Xinjiang, China, it was concluded that Cannabis plant was used for ancient customs/rituals and in medicines (Jiang et al. 2006; Manduca et al. 2012; Radwan et al. 2015). Cannabigerol and olivetol are bound into tetrahydrocannabinol and other neutral cannabinoids (Kajima and Piraux 1982; Elzinga et al. 2015).

      The toxicity levels of glutamate were reduced significantly by cannabidiol and by antioxidant compounds because several cannabinoids demonstrated antioxidant effects. Cannabidiol and tetrahydrocannabidiol also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in neuron cell cultures (Hampson et al. 1998; Radwan et al. 2008, 2015; Aizpurua-Olaizola et al. 2014). Due to differences in terpenoid composition, the cultivars of the two drug biotypes may exhibit distinctive medicinal properties (Hillig 2004). A cell suspension culture of C. sativa L. can convert cannabidiol to bound cannabielsoin and Δ-9-tetrahydrocannabinol to cannabicoumaronon (Braemer and Paris 1987; Choi et al. 2004; Fischedick et al. 2010b). Geranyl diphosphate and olivetolic acid are considered as specific intermediates in the cannabinoid biosynthesis (Fellermeier et al. 2001).

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