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      The Emperor of all Maladies

       A BIOGRAPHY OF CANCER

      SIDDHARTHA MUKHERJEE

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      logo200 Copyright

      Fourth Estate

      An imprint of HarperCollinsPublishers Ltd. 1 London Bridge Street London SE1 9GF

       www.harpercollins.co.uk

      Copyright © Siddhartha Mukherjee 2011

      The right of Siddhartha Mukherjee to be identified as the author of this work has been asserted by him in accordance with the Copyright, Designs and Patents Act 1988

      A catalogue record for this book is available from the British Library

      All rights reserved under International and Pan-American Copyright Conventions. By payment of the required fees, you have been granted the non-exclusive, non-transferable right to access and read the text of this ebook on-screen. No part of this text may be reproduced, transmitted, down-loaded, decompiled, reverse engineered, or stored in or introduced into any information storage and retrieval system, in any form or by any means, whether electronic or mechanical, now known or hereinafter invented, without the express written permission of HarperCollins ebooks

      HarperCollinsPublishers has made every reasonable effort to ensure that any picture content and written content in this ebook has been included or removed in accordance with the contractual and technological constraints in operation at the time of publication

      Source ISBN: 9780007250912

      Ebook Edition © FEBRUARY 2011 ISBN: 9780007435814 Version: 2017-09-20

      To ROBERT SANDLER (1945–1948), and to those who came before and after him.

      Illness is the night-side of life, a more onerous citizenship. Everyone who is born holds dual citizenship, in the kingdom of the well and in the kingdom of the sick. Although we all prefer to use only the good passport, sooner or later each of us is obliged, at least for a spell, to identify ourselves as citizens of that other place.

      —Susan Sontag1

      Contents

       Cover

       Title Page

       Copyright

       Dedication

       Epigraph

      An Anatomist’s Tumor

      An Army on the March

      The Cart and the Horse

      “A moon shot for cancer”

      Part Three - “Will you turn me out if I can’t get better?”

      “In God we trust. All others [must] have data”

      “The smiling oncologist”

      Knowing the Enemy

      Halsted’s Ashes

      Counting Cancer

      Part Four - Prevention Is the Cure

      “Coffins of black”

      The Emperor’s Nylon Stockings

      “A thief in the night”

      “A statement of warning”

      Photographic Insert

      “Curiouser and curiouser”

      “A spider’s web”

      STAMP

      The Map and the Parachute

      Part Five - “A Distorted Version of Our Normal Selves”

      “A unitary cause”

      Under the Lamps of Viruses

      “The hunting of the sarc”

      The Wind in the Trees

      A Risky Prediction

      The Hallmarks of Cancer

      Part Six - The Fruits of Long Endeavors

      “No one had labored in vain”

      New Drugs for Old Cancers

      A City of Strings

      Drugs, Bodies, and Proof

      A Four-Minute Mile

      The Red Queen’s Race

      Thirteen Mountains

      Atossa’s War

       Footnotes

      Notes

      Glossary

      Selected Bibliography

      Index

      Acknowledgments

      Author’s Note

       About the Author

       About the Publisher

      In 2010, about six hundred thousand Americans, and more than 7 million humans around the world, will die of cancer. In the United States, one in three women and one in two men will develop cancer during their lifetime. A quarter of all American deaths, and about 15 percent of all deaths worldwide, will be attributed to cancer. In some nations, cancer will surpass heart disease to

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