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so you can more powerfully own what you do once you’re back. And do it with help from experts.

      Not long ago, when I was visiting New York City, my friend Andrew invited me to a dinner party hosted at his hip $20 million SoHo penthouse. Given that I didn’t know he owned a place like that, I was blown away when I stepped through the door into what looked like a palace. He obviously likes surprising people, because I had no idea that the “dinner with a few friends” would turn out to be a gathering of incredibly powerful, successful, and influential people from across New York’s industries, ranging in age from twenty-five to seventy-five. The dinner was structured as a Jeffersonian dialogue. Only one guest spoke at a time, so the entire table stayed on topic. When I had an opportunity to ask a question of all the guests, I asked, “How many of you have used psychedelics for personal development at least once?”

      Every hand at the table went up, from hedge fund managers to artists, from CEOs to professors. We talked about it for the next half hour in one of the most fascinating conversations I’ve had in a long time.

      Though psychedelics have been lumped in with other illicit drugs and labeled “bad” by the government, when used therapeutically, they can be extremely powerful tools for finding self-awareness and (debatably) getting into a state of flow. High performance is an altered state. When you’re willing to go to an even more extremely altered state at times, you can learn things that will make you stronger in your regular living and working states.

      This is a topic that has come up with many of the people I’ve interviewed, from award-winning journalists to doctors and lots of people who are changing the world in between. One of them is Dr. Alberto Villoldo, who spent more than twenty-five years studying the healing practices of the Amazon and Incan shamans. He is a psychologist and a medical anthropologist, a bestselling author, and the founder of the well-respected Institute of Energy Medicine of the Four Winds Society. Back when Dr. Villoldo was twenty-seven years old, he was a broke grad student. A big pharmaceutical company gave him a grant to go to the Amazon and help it discover the next big drug. He went to remote areas and learned from native healers.

      Three months later, the pharma executives asked him what he had found. “Nothing,” he said. “I didn’t find anything because the people I visited had no Alzheimer’s, no heart disease, and no cancer.” There were no diseases to cure, so they had no need for pharmaceutical drugs. But he went back anyway and trained to become a shaman.

      Dr. Villoldo credits the differences between the health of the people in the Amazon and in Western culture to stress. When you live in a state of fight or flight, the brain secretes two steroid hormones, cortisol and adrenaline. This leads you to always being hyped up and prevents you from accessing the ecstatic, blissful state where you can actually be creative and dream the future into being, which is called a state of flow. When your brain is riddled with stress hormones, it activates the hypothalamic-pituitary-adrenal (HPA) axis. When the HPA axis is turned on, it is dedicated to the fear hormones and triggers the pituitary gland to keep manufacturing more and more stress hormones. When you are not in a state of fight or flight, however, under the right circumstances the pituitary gland can help you get into a state of flow by transforming neurotransmitters such as serotonin into dimethyltryptamine (DMT), a molecule that occurs naturally in many plants and animals.

      DMT is one of the most powerful psychoactive substances on the planet. It is prepared by various cultures for healing and ritual purposes. It triggers visionary ecstatic states. And we can produce it ourselves. We do so naturally after giving birth and at the end of life, but Dr. Villoldo says that we can do it other times, too, when we are in the right mental state.

      Yet, according to Dr. Villoldo, 99 percent of us have brains that are broken from stress and cannot create their own hallucinogenic substances. This is why we cannot hold or entertain the idea that we can manifest our dreams into reality. When Dr. Villoldo was in the jungle in the Amazon as a medical anthropologist and eventually as a student of the shamans, the shamans told him, “You have to eat the bark of that tree and those roots over there.” When Dr. Villoldo asked why, they simply said, “Because the plants told us.” That wasn’t good enough for him. He wanted to learn the science behind it, but he went ahead and ate them.

      Twenty years later, when he took these things to the lab, he found that the shamans had been repairing his brain. The barks and roots they had told him to eat had turned on the Sir2 longevity genes, and there are very few substances that do that.

      Dr. Villoldo says that we can also repair our brains by healing the gut and by consuming omega-3 fatty acids, which are essential building blocks of the brain. When we do all these things, the mystical abilities that we associate with voodoo priests, shamans, and psychics have the potential to become the natural abilities of us all. Now, we find these abilities in such a small number of the population that we consider them abnormal or even silly or laughable. But Dr. Villoldo says that they are ordinary, and so do other ancient traditions from other parts of the world, including the yoga sutras of Patanjali. When you repair the brain, heal the gut, feed the brain with high-mitochondrial foods, and trigger mitochondrial repair, these abilities can begin to appear on their own. You just have to do the basics, and then your human potential will begin to reveal itself to you.

      For thousands of years, the shamans in the Amazon have been using ayahuasca, a psychedelic that is known to induce these kinds of spiritual experiences. The ayahuasca vine contains DMT, but you can use it only when it is brewed with other plants containing chemicals called monoamine oxidase (MAO) inhibitors. Yes, the same DMT that your body can produce is the active ingredient in the powerful psychedelic ayahuasca. Without the right combination of plants, your gut would destroy the DMT and you would feel no effects from it at all.

      Studies on ayahuasca have shown that it does more than just provide a spiritual experience. In a 2015 pilot study by the University of São Paulo, researchers gave ayahuasca to six patients with treatment-resistant depression. Their symptoms of depression decreased significantly within an hour of ingesting ayahuasca, and they showed an approximately 70 percent decrease in their depressive symptoms twenty-one days after taking that single dose. They reported no significant side effects except vomiting shortly after taking it, which the shamans consider cleansing and essential to the experience.²⁶

      There is also evidence that ayahuasca can help alleviate addiction. In a 2013 study, twelve participants who went through therapy sessions while on ayahuasca reported significant decreases in alcohol and cocaine abuse even six months after the therapy ended.²⁷ Many scientists believe that ayahuasca is so effective because it increases serotonin receptor sensitivity in the brain.²⁸ Popular drugs that fight depression, such as Prozac, push your brain to release more serotonin, a neurotransmitter that contributes to feelings of well-being and happiness. But those medications take about six weeks to kick in and actually deplete the brain of serotonin in the long run,²⁹ while ayahuasca seems to better enable the brain to utilize the serotonin you already have.

      That compelling science led me to seek out the world’s top experts in plant hallucinogens. Dennis McKenna’s work focuses on ethnopharmacology and plant hallucinogens. When he received his doctorate in 1984, his doctoral research was actually on ethnopharmacological investigations of the botany, chemistry, and pharmacology of ayahuasca and oo-koo-he, two orally active tryptamine-based hallucinogens used by indigenous peoples in the northwest Amazon. (Who knew you could get a PhD in hallucinogens?)

      Dennis credits (or blames) his famous brother Terence for his interest in the topic. Terry was four years older than Dennis, who always wanted to do whatever his big brother was doing. It was the 1960s and Terry was living in Berkeley, where everyone was taking LSD. When Terry discovered DMT and shared it with Dennis, they both thought it was amazing and decided to throw everything else away and focus on what they believed was the most important discovery that man had ever made.

      Forty-five years later, Dennis hasn’t really changed his mind much about that. He believes in the therapeutic potential of psychedelics, which was pretty thoroughly explored in the 1960s as a treatment

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