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choice, because of its versatility, wide range of application and simplicity. Depending on the complexity of the matrix, an additional clean-up step could be necessary. The final extract can be injected in both GC and LC equipment or it can easily be evaporated and redissolved in a GC solvent as ethyl acetate.

       Analytical determination: Select LC or GC depending on the characteristics of the monitored compounds (GC for non-polar compounds and LC for polar pesticides). Either LC or GC should be coupled to QqQ, providing reliable, sensitive, fast and wide-scope analysis.

       LRMS vs HRMS: Use QqQ (LRMS analyzer) for targeted analysis of pesticide residues in environmental samples, whereas HRMS ((Q)-Orbitrap or (Q)-TOF) must be utilized if suspect or unknown analysis is also required.

       Data treatment: Well-set workflows and software are available for targeted analysis whereas when suspect or unknown analysis is performed, large raw data files are obtained, and high expertise and suitable software is needed for data interpretation and pesticide identification.

1.4 Future Directions and Challenges

      Nowadays, in order to increase sample throughput and minimize the number of analyses that should be performed to get a comprehensive view of the presence of pesticides in the environment, current analytical methods are monitoring a higher number of pesticides. However, they have different physico-chemical properties (from non-polar to highly polar pesticides, and from low to high volatility) and this has hampered the development of an all-in-one approach, where a wide-scope analysis can be performed, analyzing pesticides and TPs. Therefore, the combination of different platforms (GC-MS & LC-MS) is a suitable approach to minimize the number of analyses to be carried out, covering a wide-scope of pesticides, although several compounds will still require specific methods to be detected (e.g. highly polar pesticides or metabolites).

      Simplification of sample treatment is still necessary in order to minimize sample handling and therefore, error or bias associated to this step. Thus, automated methodologies that allow for monitoring of many priority substances and specific pollutants at concentrations below EQSs (e.g. water samples) are still demanding, because they are fast and cost-effective

One of the main challenges of environmental analytical chemistry is that there is a huge number of pesticides and/or TPs present in the environment, but many of them are still unknown because, for instance, the dissipation of the parent compounds has not been evaluated. Therefore, a targeted approach should be combined with suspect and unknown analyses to comprehensively assess chemical pollution related to pesticides. Special interest should be paid to the identification of new metabolites and/or TPs, and other emerging contaminants, and therefore the faster acquisition rate in HRMS analyzers and the development of efficient and user-friendly software are still needed to carry out a deconvolution process for the generation of clean mass spectra of coeluting peaks as well as an accurate putative identification. In this sense, the development of databases that include detected transformation products are needed to make this process much easier and this will facilitate the inclusion of TPs in future legislation.

Acknowledgments

      Authors gratefully acknowledge to the Spanish Ministry of Economy and Competitiveness (MINECO), Spain and FEDER-EU (project ref. PID2019-106201RB-I00) for financial support. ID thanks the University of Almeria for the Hipatia postdoctoral contract. RLR acknowledges “Plan Propio of Investigation” of University of Almería, cofunded by CAJAMAR and the Operational Program Funds Europeans of Regional Development of Andalusia (2014–2020) (FEDER), for financial support.

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