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and possibly most important, line of defense against noncommunicable diseases, before resorting to prescription drugs with possible side effects.

      The book has six distinctive features:

      1 It is inclusive of all the major lifestyle factors affecting human health.

      2 It has a textbook format and can be used for undergraduate and graduate teaching.

      3 It uses the unique and evidence‐based perspective of the traditional Mediterranean lifestyle as the gold standard of a healthy lifestyle. A plethora of scientific evidence supports the notion that the traditional Mediterranean diet/lifestyle is one of the healthiest diet/lifestyle patterns. The 2015 Dietary Guidelines for Americans identify the Healthy Mediterranean‐Style Eating Pattern/Lifestyle as probably the healthiest and easiest to follow.

      4 The “Take‐Home Messages” at the end of each chapter denote the most important points of the chapter.

      5 The “Key Points” throughout the book help the reader focus on important points.

      6 Finally, to assist the reader/student in comprehending the presented material, at the end of each chapter we present a list of “Self‐Assessment Questions” with answers provided in Appendix A.

      We hope that this book will become a valuable resource to students in medical and health‐related disciplines, and to health professionals such as nutritionists, exercise physiologists, psychologists, addiction specialists, sleep therapists, athletic trainers, physicians, nurses, and other health professionals who are using or considering using lifestyle changes to prevent and treat noncommunicable diseases. The Clinical Cases section provides specific practical tools to assist with everyday practice in the clinic; the materials presented apply to most noncommunicable diseases of today (e.g., cardiovascular disease, autoimmune diseases, stroke, most cancers, chronic kidney disease, osteoarthritis, osteoporosis), not only the specific examples we are presenting.

      We are indebted to Christina Katsagoni, PhD; Michael Georgoulis, PhD; Elena Bellou, PhD; Anastasia Diolintzi, PhD; Anastasia Papadimitriou, PhD; Glykeria Psarra, PhD; Amalia Sidossis, MD; and Ioanna Katsaroli, MS. These talented young scientists contributed tremendously to this book by offering ideas regarding book format and content, conducting thorough literature reviews, drafting and editing sections or chapters, and offering constructive criticism throughout the writing of this book. Special thank you to Christina and Michael for their invaluable help during the final stages of book editing. We would not be able to do it without them. Ms. Dafni Kyriakou was quick and effective as always in book formatting. We would also like to thank the Wiley team for their dedication and professionalism: James Watson, Anne Hunt, Tom Marriott, Cheryl Ferguson, P. Sathishwaran, and their colleagues. Finally, we would like to thank Sarah Brown for proofreading our book.

      Last but not least, we want to thank our families for their continuous love and support.

      LABROS S. SIDOSSIS, PHD Princeton, New Jersey, USA

      STEFANOS N. KALES, MD, MPH Cambridge, Massachusetts, USA

UNIT I Lifestyle Choices and Human Health

       Day by day, what you

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