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CHAPTER 3 Components of an Unhealthy Lifestyle

      Unhealthy Diets

      Research has long linked specific nutrients (e.g., refined carbohydrates and added sugars, saturated and trans fatty acids [TFAs] and sodium), foods and food groups (e.g., sweets, sugary soft drinks, red meat, and processed meats), and specific dietary patterns (e.g., Western diet) with a number of diseases and conditions: CVD, cancer, diabetes, hypertension, liver and gallbladder diseases, and obesity. Moreover, diets low in whole grains, fruits and vegetables, nuts and seeds, and ω‐3/ω‐6 fatty acids seem to be the leading dietary risk factors of mortality the last two decades.

      Regarding specific nutrients, high TFA intake increases the risk of all‐cause mortality, total CHD, and CHD mortality. Historically, studies on saturated fatty acids (SFAs) suggest positive associations with total and low‐density lipoprotein (LDL) cholesterol, coagulation markers, insulin resistance, and inflammation. Some studies have suggested that a long‐term diet high in SFAs could increase the risk for CVD and some cancers. However recent data do not fully support a direct connection between SFA and CVD.

      An increased amount of dietary salt is an important risk factor for the development of hypertention and increased overall CVD risk. On the other hand, there is an inverse relation between fiber intake and all‐cause mortality. According to the WHO, approximately 3% of deaths worldwide are attributable to low fruit and vegetable consumption. Insufficient intake of fruits and vegetables increases the risk for gastrointestinal cancer, ischemic heart disease, and stroke. Most of the benefit of consuming fruits and vegetables comes from reduction in CVD risk, but fruits and vegetables also prevent cancer. Moreover, high consumption of red and processed meat has been associated with all‐cause mortality and with several types of cancer, diabetes, and CVD mortality. However, the consumption of whole‐grain cereals has been linked to improvements of metabolic syndrome (MetS) and its components: obesity, dyslipidemia, hypertension, and hyperglycemia or T2DM. According to the World Cancer Research Fund, up to 40% of cancers can be prevented by improving diet and increasing physical activity.

      Therefore, shifting our diet from animal‐based foods to predominantly plant‐based foods may result in better health outcomes. In the following sections, we will focus on the most important components of an unhealthy diet.

Excess Caloric Intake

      Experimental studies have demonstrated that excess caloric intake can adversely affect insulin sensitivity and plasma glucose, insulin, and triglyceride levels, all positively linked to obesity. Even 1 week of hypercaloric feeding may result in elevated fasting plasma insulin, glucose, and triglyceride levels and to exacerbated insulin response, without any weight gain. These findings suggest that the observed metabolic disturbances during excess caloric intake are not necessarily linked to obesity.

       Key Point

      Observed metabolic disturbances during excess caloric intake are not necessarily linked to obesity.

      Epidemiological data suggest that intake of energy‐dense foods (i.e., more than 225–275 kcal/100 g of food), consumers’ exposure to large serving sizes, and overeating may contribute to obesity and, therefore, increase the risk for the development of chronic diseases. Overeating has also been associated with increased aging rate and decreased lifespan. According to the “rate‐of‐living/oxidative damage” theories, lifespan extension is linked to low energy metabolism, low reactive oxygen species (ROS) production rates, low molecular damage, and slow aging. Long‐term caloric restriction studies in humans show persistent metabolic slowing accompanied by reduced oxidative stress, evidence supporting the “rate‐of‐living/oxidative damage” theories of mammalian aging.

Saturated Fatty Acids

      It is now generally accepted that the effects of SFAs on CVD depend mainly on what replaces them in the diet. For example, the substitution of omega‐3 polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids for SFAs might reduce CHD risk. On the other hand, replacing SFA with carbohydrates has mixed results over the CVD risk, while there is some evidence suggesting that whole grains but not refined carbohydrates reduce CVD risk.

       Key Point

      It is now

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