Скачать книгу

[6] K m = 0.11 ± 0.01 mM V max = 1.15 ± 0.09 nmol/mg protein/2 min [27] N‐methyl nicotinamide (NMN) hMATE1 K m = 301 ± 18 μM [102] hMATE2‐K K m = 422 ± 63 μM [102] Tetraethylammonium (TEA) hMATE1 K m = 0.38 ± 0.07 mM V max = 2.37 ± 0.23 nmol/mg protein/2 min [27] K m = 0.58 ± 0.12 mM V max = 0.81 ± 0.09 nmol/mg protein/min [67] K m = 366 ± 17 μM V max = 7.54 ± 0.21 nmol/min/mg protein [29] hMATE2‐K K m = 0.83 ± 0.15 mM [6] K m = 0.76 ± 0.18 mM V max = 1.76 ± 0.25 nmol/mg protein/2 min [27] K m = 375 ± 68 μM V max = 1.16 ± 0.14 nmol/min/mg protein [29] rMate1 K m = 570 ± 64 μM [16] K m = 260 ± 10 μM V max = 5.4 ± 0.2 nmol/min/mg protein [17] rbMate1 K t = 160 ± 15 μM [20] rbMate2‐K K t = 77 ± 12 μM [20] mMate2 K m = 710 μM V max = 400 pmol/min/mg protein [22]

      a N.R.: not reported.

       3.3.2.1 Metformin

Substrates Isoforms Transport kinetics References
Acyclovir hMATE1 K m = 2.64 ± 0.40 mM V max = 1.24 ± 0.24 nmol/mg protein/2 min [27]
hMATE2‐K K m = 4.32 ± 0.44 mM V max = 1.89 ± 0.15 nmol/mg protein/2 min [27]
Atenolol hMATE1 K m = 32 ± 5 μM V max = 323 ± 12 pmol/min/mg protein [43]
hMATE2‐K K m = 76 ± 14 μM V max = 500 ± 22 pmol/min/mg protein [43]
Cephalexin hMATE1 K m = 5.9 ± 0.5 mM V max = 12.6 ± 1.1 nmol/mg protein/min [28]
Cimetidine hMATE1 K m = 0.17 ± 0.02 mM V max = 0.27 ± 0.03 nmol/mg protein/2 min [27]
K m = 7.4 ± 1.2 μM V max = 103.9 ± 6.5 pmol/mg protein/min [67]
K m = 8.00 ± 0.26 μM V max = 0.167 ± 0.020 nmol/min/mg protein [29]
hMATE2‐K K m = 0.37 ± 0.14 mM [6]
K m = 0.12 ± 0.04 mM V max = 0.23 ± 0.05 nmol/mg protein/2 min [27]
K m = 18.18 ± 0.69 μM V max = 0.216 ± 0.018 nmol/min/mg protein [29]
rMATE1 K m = 3.01 ± 0.21 μM V max = 87.9 ± 3.7 pmol/min/mg protein [17]
Cycloguanil MATE1 V max = 40 ± 9 pmol/mg protein/min [130]
MATE2‐K V max = 56 ± 15 pmol/mg protein/min [130]
Dabigatran hMATE1 K m = 4.0 ± 0.9 μM V max = 12.1 ± 0.9 pmol/mg protein/1.5 min [131]
hMATE2‐K K m = 8.0 ± 0.8 μM V max = 84.3 ± 5.4 pmol/mg protein/1.5 min [131]
Entecavir

Скачать книгу