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learning will assist physicians in intelligent analysis. Machine learning models trained with past patient data can be used to diagnose future cases. With the diagnostic capabilities to be gained by the machines, it will sometimes be possible for them to diagnose more precisely and more sensitively than the physicians. Supporting decision support systems working in expert systems logic with machine learning models will enable them to give better results.

      1.6.1 Introduction to Machine Learning

      Disease prediction and diagnosis can be made with the help of machine learning models. Disease diagnosis applications have been developed and used extensively, especially with controlled machine learning techniques. This technique has enabled models to be created from historical data and these models have sometimes been used in diagnosis and treatment. Developing a system based on machine learning is not just about developing machine learning algorithms, but rather it is done by working on data step by step from start to finish in a way similar to the data mining process. For example, determining which variables are important and which are not important in the solution of a problem directly affects the quality of the solution. This process, called feature selection, determines which parameters will be used in the system to be installed. The feature selection process is often achieved by establishing the correct relationships between targeted data and predictive data.

      The feature selection phase is followed by feature transformation. Data transformation, which is a method that improves data quality, has recently emerged as feature engineering, which includes feature studies performed to increase prediction success. Like feature selection, feature engineering will also affect the success of the result. Both feature selection and feature engineering also solve the problem of high dimensionality in data. Loss of data and methods of combating loss are also important. The fight against lost values ​​is sometimes carried out by estimating the lost value and sometimes by replacing it with other values.

      The most prominent techniques – supervised and unsupervised learning – will be explained in the following paragraphs.

      1.6.2 Machine Learning Algorithms

      Figure 1.2 Supervised and unsupervised machine learning.

      1.6.2.1 Supervised Learning

      Supervised learning consists of two basic steps: creating a model with labeled data and testing with untagged data, the two prominent techniques in the category of supervised learning algorithms. Classification, one of the two prominent techniques in the category of supervised learning algorithms, is a supervised learning technique in which the target variable is of categorical type, while regression, the other prominent technique, is of the numerical type of the target variable. Operations are performed based on a model in which the target variable calculated from predictive variables is estimated. The purpose of classification is to assign records seen for the first time to one of the predefined categories. Identification and modeling of categories takes place with the help of training data. Training data and machine learning algorithms come together to form machine learning models. Machine learning models also match the records to the classroom that suits them best.The most important feature that distinguishes supervised learning from unsupervised learning is label information in supervised data. It is the class label in the data that provides the control. Although the output of both methods is different, the goal is to estimate the value of the output variable based on input variables.

      1.6.2.1.1 Decision Trees

      1.6.2.1.2 Naive Bayes

      1.6.2.1.3 Support Vector Machines

      SVMs were first introduced by Vapnik [31]. The technique uses what we call support vectors to distinguish between data points belonging to different classes. The method aims to find the hyperplane that will best distinguish (margin maximization) different classes from each other. In its simplest form, it distinguishes two-class spaces from each other with the help of two equations wTx + b = + 1 and wTx + b = -1. SVMs were first developed in accordance with linear classification and, later, kernel functions for nonlinear spaces were developed. Kernel functions express a transformation between linear and nonlinear spaces. There are types such as linear, polynomial, radial basis function, and sigmoid. Depending on the nature of the data used, kernel functions can be superior to each other.

      1.6.2.1.4 K-Nearest Neighbor

      1.6.2.1.5 Neural Nets

      An ANN is a machine learning method that emulates human learning. ANNs,

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