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areas (e.g., drug risks, school risks, violence risks, etc.), and that the linkages between those areas were weakly associated. The models of risk for the teenagers were then valuable in constructing HIV and other risk prevention programs which improved the students understanding of the need to link among risks in order to prevent negative outcomes, and the need to strengthen boundaries between risks to avoid them.

      Social Organization and Structure: Cultural Contexts Research

      The bulk of health-related research in other disciplines has either focused on individuals and their attributes, or on population samples collected through probabilistic sampling procedures. While this approach has a number of strengths, its weaknesses are twofold. First, the cultural context of health problems is all too often ignored by individually centered approaches. Second, people spend a significant portion of their lives within small interactive groups, where their behavior may be impacted as much or more strongly by the group than by any individual characteristic that they bring to the group. Anthropological midrange theory has been highly productive in establishing the importance of cultural contexts and the organization and structure of human systems. These approaches derive from theories of kinship and social network analysis and the impact of cultural structures on human behavior.

      Ethnographic network mapping allows applied anthropologists to describe the participants, the behaviors, the kinship and friendship ties, and the consequences of small “bounded groups” in a community. It is accomplished through extensive qualitative interviewing at the community level. In the drug field, the composite ethnographic characteristics of the networks have subsequently been used to create a “drug network” typology or classification system that describes the individual and group context of drug use (such as crack houses, local manufacturing, and distribution). Trotter et al. (1995) and Williams and Johnson (1993) have demonstrated that this type of data is extremely useful for targeting intervention and education activities for the highest risk groups, based on multiple risk criteria. The data can also provide important information about the sub-epidemics that are likely to be part of drug use in network groups (Trotter et al. 1993). In HIV and drug risk prevention, several projects have tested very useful midrange theory to identify network structural elements. These findings provide public health measures of HIV and drug risk conditions (Trotter et al. 1995; Weeks et al. 2001, 2006) as well as epidemiological comparisons of HIV risks within their personal network context in cities around the United States (Williams et al. 1995).

      More recently, social network paradigms, combined with community-based participatory principles (CBPR) have provided an important theoretical foundation for understanding infectious disease carriage and transmission through the confluence of Staphylococcus aureus genomics and network analytics. The project has focused on health disparities in Staphylococcus aureus transmission and carriage in a border Region of the United States based on cultural differences in social Relationships (Pearson et al. 2019), providing an example of the potential confluence between biology, social organization, culture, and communication. The epidemiological aspects of genomics are a strong fit with paradigms that include organized social relationships.

      Cultural Ecology, Critical Medical Anthropology, and Cultural Epidemiology Theories

      In addition, the direct observation of behaviors to determine the impact of the environment on behavior constitutes a primary methodology for health ecological studies. Some of these studies have targeted the results of prevention or behavioral change programs and culturally competent interventions in risk taking behavior. A linked series of studies of needle sharing and needle hygiene practices supported by the National Institute on Drug Abuse exemplifies midrange theory combined with observational methods in a cultural ecological context. The component studies of this project focus on context specific uses of injection equipment among drug users in the United States, as part of HIV risk reduction efforts for drug injectors. Descriptive observations in this realm (Koester 1994; Page 1990; Page et al. 1990) explore both the meaning and the processes of injection drug use, needle sharing, and the public health consequences of drug paraphernalia laws (laws that restrict the possession of syringes that might be used for drug abuse). Later studies (Clatts et al. 1996; Singer et al. 1995) explore the micro-environmental consequences of needle hygiene and needle sharing in depth. One example of the latter approach is the Needle Hygiene Project, conducted by the National Institutes on Drug abuse Cooperative Agreement Program (Needle et al ND, Koester 1994). These studies have led to changes in the recommended messages and training processes for HIV risk reduction among injection drug users.

      On a population health level, multidisciplinary teams have also used cultural–ecological models to address risks, and potential prevention activities associated with environmental contaminants. There is considerable interest, and resources available, to identify and mitigate health disparities in underserved populations, and there are a growing number of trans-disciplinary protocols to achieve that goal. (Trotter et al. 2019).

      Cross-cultural Applicability Midrange Theory and Methods

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