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Volume I

      To my wife, Caroline, and children and grandchildren, present and future, for their invaluable contributions to my work, my life, and my happiness!

       Alan J. Sinclair

      To all my older friends and patients who have taught me geriatrics; to my wife, Pat, and my children, Robert, Susan, and Jacqueline; and to my grandchildren, Amanda, Conor, Katelyn, Nicole, Paige, and John, who are my eternal joy and my hope for the future of eldercare.

       John E. Morley

      Geriatric medicine is moving to healthy ageing and prevention. Of course, we will still have to take care of frail and sick older people, but this move will change geriatric medicine in everyday clinical practice more each year. I dedicate this textbook to my family and all those scientists that have inspired us to bring about positive change in the way we manage older people, such as Professor Alan Sinclair and those who continue to excel, as otherwise this textbook would not have been possible.

       Bruno Vellas

      To my family.

       Matteo Cesari

      To my patients, who taught me the most important lessons on how to age gracefully.

       Medha Munshi

      Pathy’s Principles and Practice of Geriatric Medicine

       SIXTH EDITION

       Volume 1

      Edited by

      Alan J. Sinclair

      Director, Foundation for Diabetes Research in Older People (fDROP);

      King’s College, London, UK

      John E. Morley

      Emeritus Professor of Internal Medicine

      Division of Geriatric Medicine

      Saint Louis University School of Medicine

      St Louis, Missouri, USA

      Bruno Vellas

      Chair, Gérontopôle & Department of Geriatric Internal Medicine

      Toulouse University Hospital

      Toulouse, France

      Matteo Cesari

      Associate Professor of Geriatrics

      Università di Milano;

      Head, Geriatric Unit

      IRCCS Istituti Clinici Scientifici Maugeri

      Milano, Italy

      Medha Munshi

      Associate Professor of Medicine

      Harvard Medical School;

      Geriatrician and Endocrinologist

      Beth Israel Deaconess Medical Center

      Boston, Massachusetts, USA

      This edition first published 2022

      © 2022 John Wiley & Sons Ltd

      Edition History John Wiley & Sons, Ltd (5e, 2012)

      All rights reserved. No part of this publication may be reproduced, stored in

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