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CHAPTER 14 Weight loss

       Isabelle Bourdel‐Marchasson1 and David R. Thomas2

      ¹ CHU Bordeaux, Pôle de gérontologie, Université Bordeaux/CNRS, Bordeaux, France

      ² Saint Louis University Health Sciences Center, St Louis, Missouri, USA

Introduction

      Weight loss is an important clinical sign included in the impaired general condition syndrome with asthenia and anorexia. This finding should lead to an etiological investigation. Unintentional weight loss is also included in the frailty phenotype described by Fried et al. with four other criteria: low gait speed, exhaustion, decreased muscle strength, and decreased physical activity.¹

      Weight loss, isolated or included in the frailty syndrome, is common in older adults and is a harbinger of poor outcomes. A loss of 10% or more of body weight between age 50 and old age is associated with a 60% increase in mortality compared with people with stable weight.² Involuntary

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