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2016 1574 Not stated Not stated 10.3 Mean age of those experiencing adverse events = 61.8, vs. 55.4 P < 0.001 Sweden (Nilsson) 2018 64971 Not stated >65 11.7 12.9 9.6 P < 0.001

      Source: Adapted from Thomas and Petersen19.

Study method Advantages Disadvantages
Administrative data analysis Uses readily available data May rely on incomplete and inaccurate data
Inexpensive The data are divorced from clinical context
Record review/chart review Uses readily available data Judgements about adverse events not reliable
Commonly used Medical records are incomplete Hindsight bias
Review of electronic medical records Inexpensive after initial investment Monitors in real time Integrates multiple data sources Susceptible to programming and/or data‐entry errors Expensive to implement
Observation of patient care Potentially accurate and precise Provides data otherwise unavailable Detects more active errors than other methods Time‐consuming and expensive Difficult to train reliable observers Potential concerns about confidentiality Possible to be overwhelmed with information
Active clinical surveillance Potentially accurate and precise for adverse events Time‐consuming and expensive

      Source: Adapted from Thomas and Petersen19.

Study method Advantages Disadvantages
Morbidity and mortality conferences and autopsy Can suggest contributory factors Familiar to healthcare providers Hindsight bias Reporting bias Focused on diagnostic errors Infrequently used
Case analysis/root cause analysis Can suggest contributory structured systems approach Includes recent data from interviews Hindsight bias Tends to focus on severe events Insufficiently standardized in practice
Claims analysis Provides multiple perspectives (patients, providers, lawyers) Hindsight bias Reporting bias Non‐standardized source of data
Error‐reporting systems Provide multiple perspectives over time Can be a part of routine operations Reporting bias Hindsight bias

      System and organizational factors

      Source: Adapted from Redelmeier24.

Name Definition Example
Availability heuristic Making judgements based on cases that spring easily to mind ‘The last time I saw a patient with fever and a headache, it was only flu, so it is likely to be so in this case too’ (actually meningitis)
Anchoring heuristic Sticking with initial impressions The confused elderly patient who has a ‘UTI’ on admission (despite a negative MSU), whose severe constipation goes unnoticed
Framing effects Making a decision based on how the information is presented to you ‘A&E referred this patient with fever and haemoptysis as “pneumonia”, so that is the most likely diagnosis even though the CXR is normal’ (actually a PE)
Blind obedience Showing undue deference to seniority or technology – ‘they must be right, and I must be wrong’! ‘My consultant said that this patient could go home, so I am going to ignore concerns raised by nursing staff’; ‘The blood results show a normal haemoglobin even though this patient looks clinically anaemic – the blood results must be right’
Premature closure Being satisfied too easily with an explanation In a patient with staphylococcal sepsis, assuming the source of sepsis is their cellulitic leg and missing their underlying endocarditis
Schematic illustration of reason’s Swiss cheese model.

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