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      Enzyme‐Based Organic Synthesis

       Cheanyeh Cheng

       Department of Chemistry

       Chung Yuan Christian University

       Chungli

       Taiwan

      This edition first published 2022

      © 2022 John Wiley & Sons, Inc.

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

      The right of Cheanyeh Cheng to be identified as the author of this work has been asserted in accordance with law.

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       Library of Congress Cataloging‐in‐Publication Data

      Names: Cheng, Cheanyeh, author.

      Title: Enzyme‐based organic synthesis / Cheanyeh Cheng, Department of Chemistry, Chung Yuan Christian University, Chungli, Taiwan.

      Description: Hoboken, NJ : Wiley, 2022. | Includes bibliographical references and index.

      Identifiers: LCCN 2021031980 (print) | LCCN 2021031981 (ebook) | ISBN 9781118027943 (hardback) | ISBN 9781118995143 (adobe pdf) | ISBN 9781118995150 (epub)

      Subjects: LCSH: Enzymes–Synthesis. | Organic compounds–Synthesis. | Biocatalysis. | Enzymes–Biotechnology.

      Classification: LCC TP248.E5 C44 2021 (print) | LCC TP248.E5 (ebook) | DDC 661/.805–dc23

      LC record available at https://lccn.loc.gov/2021031980 LC ebook record available at https://lccn.loc.gov/2021031981

      Cover Design: Wiley

      Cover Image: Courtesy of author

      Preface

      The first time I was introduced to the field of microbiology was during the year 1982–1987, when I studied in the United States in the Department of Chemical & Biochemical Engineering of the Graduate and Professional School of Rutgers University to pursue my PhD degree. I was surprised that bacteria can live in an environment without air and at a temperature much higher than room temperature as well as ferment glucose to acetic acid. This study ignited my interest in the research of microorganisms and enzymes. As soon as I finished my PhD study in 1987, I came back to my alma mater, Chung Yuan Christian University, and worked as an associate professor in the Department of Chemistry, the place where I obtained my BS degree in 1974. I decided to continue my PhD research work to study the enzymatic cellulose hydrolysis for producing glucose using raw materials such as waste paper, dead tree branch, or waste bamboo chopsticks and the enantioselective bioreduction of ketones catalyzed by whole yeast cells for producing chiral secondary alcohols. I also taught a course called bioorganic chemistry, which focuses on the chemo‐, stereo‐, and regioselective enzyme or whole microbial cell catalyzed organic synthesis.

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